Different ratios of lactide and glycolide in PLGA affect the surface property and protein delivery characteristics of the PLGA microspheres with hydrophobic additives

Journal of Microencapsulation

Volumn 23, Issue 1, 2006, Pages 15-27

  Chung, Tze Wen ^a   Tsai, Yu Lin ^b   Hsieh, Jui Hsiang ^b   Tsai, Wei Jean ^a  

^a NATIONAL YUNLIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Hydrophobic additives; PLGA microspheres; Protein delivery; Ratios of lactide and glycolide; Surface quantity of additives

Indexed keywords

ALBUMIN; DRUG ADDITIVE; MICROSPHERE; PHOSPHATIDYLCHOLINE; POLYGLACTIN; POLYLACTIDE; POLYMER;

ARTICLE; DRUG DELIVERY SYSTEM; ENCAPSULATION; FOURIER TRANSFORMATION; HYDROPHOBICITY; INFRARED SPECTROSCOPY; PARTICLE SIZE; SURFACE PROPERTY;

ALBUMINS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYDROPHOBICITY; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; SURFACE PROPERTIES;

EID: 33744738192     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040500286110     Document Type: Article

References (19)

1. Blanco, D and Alonso, MJ. (1998) Protein encapsulation and release from poly (lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of the co-encapsulation of surfactants European Journal of Pharmaceutics & Biopharmaceutics, 45, pp. 285-294.
2. Chen, XQ and Yang, YY and Wang, L and Chung, TS. (2001) Effects of inner water volume on the peculiar surface morphology of microspheres fabricated by double emulsion technique Journal of Microencapsulation, 18, pp. 637-649.
3. Chung, TW and Huang, YY and Tsai, YL and Liu, YZ. (2002) Effects of solvent evaporation rate on the properties of protein-loaded PLLA and PDLLA microspheres fabricated by emulsion-solvent evaporation process Journal of Microencapsulation, 19, pp. 463-471.
4. Evora, C and Soriano, I and Rogers, RA and Shakesheff, KM and Hanes, J and Langer, R. (1998) Relating the phagocytosis of microspheres by alveolar macrophages to surface chemistry: The effect of 1,2-Dipalmitoyl-phosphatidylcholine Journal of Controlled Release, 51, pp. 143-152.
5. Feng, SS and Huang, GF. (2001) Effects of emulsifiers on the controlled release of pacitaxel from nanospheres of biodegradable polymers Journal of Controlled Release, 71, pp. 53-69.
6. Huang, YY and Chung, TW and Wu, CI. (1998) Effects of saturated/ unsaturated phosphatidylcholine (PC) ratio on the stability of liposome-encapsulated hemoglobin International Journal of Pharmaceutics, 172, pp. 161-168.
7. Jeyanth, R and Mehta, RC and Thanoo, BC and Deluca, PP. (1996) Effects of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery Journal of Controlled Release, 38, pp. 235-244.
8. Jones, BG and Dickinson, PA and Gumbleton, M and Kellaway, IW. (2002) The inhibition of phagocytosis of respirable microspheres by alveolar and peritoneal macrophages International Journal of Pharmaceutics, 236, pp. 65-79.
9. Kissel, T and Brich, Z and Bantle, S and Lancranjam, I and Nimmerfall, F and Vit, P. (1991) Parental depot-systems on the basis of biodegradable polyesters Journal of Controlled Release, 16, pp. 27-42.
10. Liu, DZ and Chen, WP and Lee, CP and Wu, SL and Wang, YC and Chung, TW. (2004) Effects of alginate coated on PLGA microspheres for delivery tetracycline hydro-chloride to periodontal pockets Journal of Microencapsulation, 21, pp. 637-642.
11. Millard, C and Coudane, J and Rault, I and Vert, M. (2000) The use of additives to modulate the release of sparingly water soluble drug entrapped in PLGA50 microparticles Journal of Microencapsulation, 17, pp. 81-93.
12. Mu, L and Feng, SS. (2001) Fabrication, characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers Journal of Controlled Release, 76, pp. 239-254.
13. Nihant, N and Schugens, C and Grandfiles, R and Jerome, R and Teyssie, P. (1994) Polylactide microparticles prepared by double emulsion/ evaporation technique I. Effect of primary emulsion stability. Pharmaceutical Research, 11, pp. 1479-1486.
14. Pistel, KF and Kissel, T. (2000) Effects of salt addition on the micro-encapsulation of proteins using w/o/w double emulsion technique Journal of Microencapsulation, 17, pp. 467-483.
15. Sandor, M and Riechel, A and Kaplan, I and Mathiowitz, E. (2002) Effect of Lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly (lactide-co-glycolide) (PLGA) microspheres Biochimica et Biophysica Acta, 1570, pp. 63-74.
16. Schwendeman, SP and Cardamone, M and Kilibanov, A and Langer, R.(1996) Stability of proteins and their delivery from biodegradable polymer microspheres. In Microparticulate systems for the delivery of proteins and vaccines. (pp. 1-49). New York: Marcel-Dekker.
17. Smith, PK and Krobn, RI and Mallia, AK. (1985) Measurement of protein using bicinchoninic acid Analytical Biochemistry, 150, pp. 76-85.
18. Stewart, JCM. (1980) Colorimetric determination of phospholipids with ammonium ferrothio-cyanate Analytical Biochemistry, 104, pp. 10-14.
19. Touitou, E and Dayan, N and Bergrlon, L and Gadin, B and Eliaz, M. (2000) Ethoomes-novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties Journal of Controlled Release, 65, pp. 403-411.