Involvement of the human cerebellum in short-term and long-term habituation of the acoustic startle response: A serial PET study

Clinical Neurophysiology

Volumn 117, Issue 6, 2006, Pages 1290-1300

  Frings, Markus ^a   Awad, Nadia ^a   Jentzen, Walter ^a   Dimitrova, Albena ^a   Kolb, Florian P ^b   Diener, Hans Christoph ^a   Timmann, Dagmar ^a   Maschke, Matthias ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cerebellum; Habituation; Motor learning; Positron emission tomography; Startle response

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN STEM; CEREBELLUM; CONDITIONING; CONTROLLED STUDY; ELECTROMYOGRAPHY; FEEDBACK SYSTEM; HABITUATION; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MESENCEPHALON; NORMAL HUMAN; PONS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STARTLE REFLEX; STATISTICAL SIGNIFICANCE;

ACOUSTIC STIMULATION; ADULT; CEREBELLUM; CONDITIONING (PSYCHOLOGY); ELECTROMYOGRAPHY; HABITUATION, PSYCHOPHYSIOLOGIC; HUMANS; LEARNING; MALE; MESENCEPHALON; PONS; POSITRON-EMISSION TOMOGRAPHY; STARTLE REACTION;

EID: 33744736919     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinph.2006.02.025     Document Type: Article

References (47)

1. Albert T.J., Dempsey C.W., and Sorenson C.A. Anterior vermal stimulation: effect on behavior and basal forebrain neurochemistry in rat. Biol Psychiatry 20 (1985) 1267-1276
2. Bloedel J.R., and Bracha V. On the cerebellum, cutaneomuscular reflexes, movement control and the elusive engrams of memory. Behav Brain Res 68 (1995) 1-44
3. Davis M. Effects of interstimulus interval length and variability on startle-response habituation in the rat. Journal of Comparative and Physiological Psychology 72 (1970) 177-192
4. Davis M., Gendelman D.S., Tischler M., and Kehne J.H. A primary acoustic startle circuit: lesion and stimulation studies. J Neurosci 2 (1982) 791-805
5. Davis H.P., and Squire L.R. Protein synthesis and memory: a review. Psychol Bull 96 (1984) 518-559
6. Dimitrova A., Weber J., Redies C., Kindsvater K., Maschke M., Kolb F.P., Forsting M., Diener H.C., and Timmann D. MRI atlas of the human cerebellar nuclei. NeuroImage 17 (2002) 240-255
7. Doyon J., Penhune V., and Ungerleider L.G. Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning. Neuropsychologia 41 (2003) 252-262
8. Duvernoy H.M. The human brain stem and cerebellum (1995), Springer, New York
9. Fischer H., Andersson J.L.R., Furmark T., and Fredrikson M. Fear conditioning and brain activity: a positron emission tomography study in humans. Behav Neurosc 114 (2000) 671-680
10. Frackowiak R.S.J., and Friston K.J. Functional anatomy of the human brain: positron emission tomography - a new neuroanatomical technique. J Anat 184 (1994) 211-225
11. Frings M., Maschke M., Erichsen M., Jentzen W., Müller S.P., Kolb F.P., Diener H.C., and Timmann D. Involvement of the human cerebellum in fear-conditioned potentiation of the acoustic startle response: a PET study. NeuroReport 13 (2002) 1275-1278
12. Friston K.J., Frith C.D., Liddle P.F., Dolan R.J., Lammertsma A.A., and Frackowiak R.S.J. The relationship between global and local changes in PET scans. J Cerebr Blood Flow Metab 10 (1990) 458-466
13. Gerwig M., Dimitrova A., Kolb F.P., Maschke M., Brol B., Kunnel A., Boring D., Thilmann A.F., Forsting M., Diener H.C., and Timmann D. Comparison of eyeblink conditioning in patients with superior and posterior inferior cerebellar lesions. Brain 126 (2003) 71-94
14. Gerwig M., Hajjar K., Dimitrova A., Maschke M., Kolb F.P., Frings M., Thilmann A.F., Forsting M., Diener H.C., and Timmann D. Timing of conditioned eyeblink responses is impaired in cerebellar patients. J Neurosci 25 (2005) 3919-3931
15. Grodd W., Hülsmann E., Lotze M., Wildgruber D., and Erb M. Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization. Hum Brain Mapp 13 (2000) 55-73
16. Groves P.M., Wilson C.J., and Miller S.W. Habituation of the acoustic startle response: A neural system analysis of habituation in the intact animal. Advances in psychobiology (1976), Wiley, New York 327-379
17. Hebb D.O. The organization of behavior (1949), Wiley, New York
18. Holmes G. The cerebellum of man (Hughlings Jackson memorial lecture). Brain 62 (1939) 1-30
19. Jordan W.P., and Leaton R.N. Habituation of the acoustic startle response in rats after lesions in the mesencephalic reticular formation or in the inferior colliculus. Behav Neurosci 97 (1983) 710-724
20. Jueptner M., and Weiller C. Does measurement of regional cerebral blood flow reflect synaptic activity?. Implications for PET and fMRI. Neuroimage 2 (1995) 148-156
21. Jueptner M., Ottinger S., Fellows S.J., Adamschewski J., Flerich L., Muller S.P., Diener H.C., Thilmann A.F., and Weiller C. The relevance of sensory input for the cerebellar control of movements. Neuroimage 5 (1997) 41-48
22. Koch M. The neurobiology of startle. Prog Neurobiol 59 (1999) 107-128
23. Larsell O. Anatomy of the Nervous System. 2nd ed. (1951), Appleton Century Crofts, New York
24. Leaton R.N., and Supple W.F. Cerebellar vermis: essential for long-term habituation of the acoustic startle response. Science 232 (1986) 513-515
25. Leaton R.N., and Supple W.F. Medial cerebellum and long-term habituation of acoustic startle in rats. Behav Neurosci 105 (1991) 804-816
26. Leaton R.N., Cassella J.V., and Borszcz G.S. Short-term and long-term habituation of the acoustic startle response in chronic decerebrate rats. Behav Neurosci 99 (1985) 901-912
27. Logothetis N.K., Pauls J., Augath M., Trinath T., and Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 412 (2001) 150-157
28. Lopiano L., De'Sperati C., and Montarolo P.G. Long-term habituation of the acoustic startle response: role of the cerebellar vermis. Neuroscience 35 (1990) 79-84
29. Martin T.A., Keating J.G., Goodkin H.P., Bastian A.J., and Thach W.T. Throwing while looking through prisms I. Focal olivocerebellar lesions impair adaptation. Brain 119 (1996) 1183-1198
30. Maschke M., Kolb F.P., Drepper J., Peper M., Lachauer S., Müller S.P., Diener H.C., and Timmann D. A possible role of the human cerebellum in conditioning of the jaw-opening reflex. Neurosci Let 285 (2000) 213-217
31. Maschke M., Drepper J., Kindsvater K., Kolb F.P., Diener H.C., and Timmann D. Fear conditioned potentiation of the acoustic blink reflex in patients with cerebellar lesions. J Neurol Neurosurg Psychiatry 68 (2000) 358-364
32. Maschke M., Drepper J., Kindsvater K., Kolb F.P., Diener H.C., and Timmann D. Involvement of the human medial cerebellum in long-term habituation of the acoustic startle response. Exp Brain Res 133 (2000) 359-367
33. Maschke M., Schugens M., Kindsvater K., Drepper J., Kolb F.P., Diener H.C., Daum I., and Timmann D. Fear-conditioned changes of heart rate in patients with medial cerebellar lesions. J Neurol Neurosurg Psychiatry 72 (2002) 116-118
34. Niessing J., Ebisch B., Schmidt K.E., Niessing M., Singer W., and Galuske R.A. Hemodynamic signals correlate tightly with synchronized gamma oscillations. Science 309 (2005) 948-951
35. Ornitz E.M., and Guthrie D. Long-term-habituation and sensitization of the acoustic startle response in the normal adult human. Psychophysiology 26 (1989) 166-173
36. Pissiota A., Frans O., Fredrikson M., Langström B., and Flaten M.A. The human startle reflex and pons activation: a regional cerebral blood flow study. Eur J Neurosci 15 (2002) 395-398
37. Ramnani N., Toni I., Josephs O., Ashburner J., and Passingham R.E. Learning- and expectation-related changes in the human brain during motor learning. J Neurophysiol 84 (2000) 3026-3035
38. Schmahmann J.D., Doyon J., Toga A.W., Petrides M., and Evans A.C. MRI Atlas of the Human Cerebellum (2000), Academic Press, San Diego
39. Snider R.S., and Eldred E. Cerebro-cerebellar relationships in the monkey. J Neurophysiol 15 (1952) 27-40
40. Supple W.F., and Leaton R.N. Cerebellar vermis: essential for classical conditioned bradycardia in the rat. Brain Res 509 (1990) 17-23
41. Talairach J., and Tournoux P. Co-planar stereotaxis atlas of the human brain (1988), Georg-Thieme, New York
42. Timmann D., Musso C., Kolb F.P., Rijntjes M., Jüptner M., Müller S.P., Diener H.C., and Weiller C. Involvement of the human cerebellum during habituation of the acoustic startle response: a PET study. J Neurol Neurosurg Psychiatry 65 (1998) 771-773
43. Timmann D., Baier P.C., Diener H.C., and Kolb F.P. Classically conditioned withdrawal reflex in cerebellar patients1. Impaired conditioned responses. Exp Brain Res 130 (2000) 453-470
44. Weber M., Schnitzler H.U., and Schmid S. Synaptic plasticity in the acoustic startle pathway: the neuronal basis for short-term habituation?. Eur J Neurosci 16 (2002) 1325-1332
45. Yeo C., and Hesslow G. Cerebellum and conditioned reflexes. Trends Cogn Sci 2 (1998) 322-330
46. Yeomans J.S., and Frankland P.W. The acoustic startle reflex: neurons and connections. Brain Res Rev 21 (1996) 301-314
47. Zhao Z., and Davis M. Fear-potentiated startle in rats is mediated by neurons in the deep layers of the superior colliculus/deep mesencephalic nucleus of the rostral midbrain through the glutamate non-NMDA receptors. J Neurosci 24 (2004) 10326-10334