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Kaiser Family Foundation, Pub. no. 7031, Section 1, Exhibit 1.21, 8 February
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Henry J. Kaiser Family Foundation, Trends and Indicators in the Changing Health Care Marketplace, Pub. no. 7031, Section 1, Exhibit 1.21, 8 February 2006, http://www.kff.org/insurance/7031/index.cfm (accessed 22 March 2006).
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Trends and Indicators in the Changing Health Care Marketplace
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Henry, J.1
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Health Spending Growth Slows in 2003
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C. Smith et al., "Health Spending Growth Slows in 2003," Health Affairs 24, no. 1 (2005): 185-194.
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Smith, C.1
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Ghost Story: At Medical Journals, Writers Paid by Industry Play Big Role
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13 December
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A.W. Mathews, "Ghost Story: At Medical Journals, Writers Paid by Industry Play Big Role," Wall Street Journal, 13 December 2005;
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(2005)
Wall Street Journal
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Mathews, A.W.1
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5
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33744748008
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Eli Lilly to Pay $36 Million Fine
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22 December
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and "Eli Lilly to Pay $36 Million Fine," Wall Street Journal, 22 December 2005.
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(2005)
Wall Street Journal
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6
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33744772935
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Big Drug Makers See Sales Decline with Their Image
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14 November
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A. Berenson, "Big Drug Makers See Sales Decline with Their Image," New York Times, 14 November 2005;
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(2005)
New York Times
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Berenson, A.1
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Take Your Pills, Ignore Your Belly
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20 November
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and G. Critser, "Take Your Pills, Ignore Your Belly," Los Angeles Times, 20 November 2005.
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(2005)
Los Angeles Times
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Critser, G.1
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8
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12844253819
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Prescription Drugs and the Changing Patterns of Treatment for Mental Disorders, 1996-2001
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S.H. Zuvekas, "Prescription Drugs and the Changing Patterns of Treatment for Mental Disorders, 1996-2001," Health Affairs 24, no. 1 (2005): 195-205.
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Health Affairs
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Zuvekas, S.H.1
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10
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Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease: The Practice Parameters Committee of the American College of Gastroenterology
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K.R. DeVault and D.O. Castell, "Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease: The Practice Parameters Committee of the American College of Gastroenterology," American Journal of Gastroenterology 94, no. 6 (1999): 1434-1442.
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DeVault, K.R.1
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11
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0038109097
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Strategies and Tactics in the Treatment of Depression
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ed. G.O. Gabbard (Washington: American Psychiatric Publishing)
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See, for example, A.J. Rush and D.J. Kupfer, "Strategies and Tactics in the Treatment of Depression," in Treatments of Psychiatric Disorders, ed. G.O. Gabbard (Washington: American Psychiatric Publishing, 2001), 1427-1428;
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Treatments of Psychiatric Disorders
, pp. 1427-1428
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Rush, A.J.1
Kupfer, D.J.2
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12
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0027461577
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Single-Drug Therapy for Hypertension in Men: A Comparison of Six Antihypertensive Agents with Placebo
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and B.J. Materson et al., "Single-Drug Therapy for Hypertension in Men: A Comparison of Six Antihypertensive Agents with Placebo," New England Journal of Medicine 328, no. 13 (1993): 914-921.
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Materson, B.J.1
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Choosing a First-Line Antidepressant: Equal on Average Does Not Mean Equal for Everyone
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G. Simon, "Choosing a First-Line Antidepressant: Equal on Average Does Not Mean Equal for Everyone," Journal of the American Medical Association 286, no. 23 (2001): 3003-3004.
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Simon, G.1
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Fixed-Dose Trial of the Single Isomer SSRI Escitalopram in Depressed Outpatients
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W.J. Burke, I. Gergel, and A. Bose, "Fixed-Dose Trial of the Single Isomer SSRI Escitalopram in Depressed Outpatients," Journal of Clinical Psychiatry 63, no. 4 (2002): 331-336.
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, vol.63
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, pp. 331-336
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Burke, W.J.1
Gergel, I.2
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0347257056
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Managing Psychotropic Drug Costs: Will Formularies Work?
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H.A. Huskamp, "Managing Psychotropic Drug Costs: Will Formularies Work?" Health Affairs 22, no. 5 (2003): 84-96.
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Huskamp, H.A.1
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19
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30744462964
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(see NME and NDA Approvals), 1 December
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U.S. Food and Drug Administration, Center for Drug Evaluation and Research, "CDER Drug and Biologic Approval Reports" (see NME and NDA Approvals), 1 December 2005, http://www.fda.gov/cder/rdmt (accessed 14 February 2006).
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(2005)
CDER Drug and Biologic Approval Reports
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20
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33744761856
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-
note
-
I do not include NDAs for drugs with indications for Alzheimer's disease.
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21
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0037373590
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New Estimates of Drug Development Costs
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R.G. Frank, "New Estimates of Drug Development Costs" (Editorial), Journal of Health Economics 22, no. 2 (2003): 325-330.
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Frank, R.G.1
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33744737604
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note
-
Based on author's calculations from IMS Health data on antidepressant sales.
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23
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33744756711
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Why Are Atypical Drug Users Angry?
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19 August
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For example, see E. Pringle, "Why Are Atypical Drug Users Angry?" Online Journal, 19 August 2005, http://www.onlinejournal.com/ health/081905Pringle/081905pringle.html (accessed 19 December 2005).
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The Choice of Antipsychotic Drugs for Schizophrenia
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R. Freedman, "The Choice of Antipsychotic Drugs for Schizophrenia" (Editorial), New England Journal of Medicine 353, no. 12 (2005): 1286-1288.
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Freedman, R.1
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25
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33744742325
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-
note
-
The first atypical, clozapine, was introduced in the 1970s. Because clozapine can result in agranulocytosis, its use is typically limited to patients whose symptoms are resistant to other treatments.
-
-
-
-
26
-
-
33744725910
-
-
I used retail prices from http://www.drugstore.com for the lower end of the usual effective dose range from the 2004 Tarascon Pocket Pharmacopoeia.
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(2004)
Tarascon Pocket Pharmacopoeia
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28
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11844249355
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Effectiveness versus Efficacy of Second-Generation Antipsychotics: Haloperidol without Anticholinergics as a Comparator
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For example, R.A. Rosenheck, "Effectiveness versus Efficacy of Second-Generation Antipsychotics: Haloperidol without Anticholinergics as a Comparator," Psychiatric Services 56, no. 1 (2005): 85-92;
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Psychiatric Services
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Rosenheck, R.A.1
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and J.M. Davis, N. Chen, and I.D. Glick, "A Meta-Analysis of the Efficacy of Second-Generation Antipsychotics," Archives of General Psychiatry 60, no. 6 (2003): 553-564.
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Davis, J.M.1
Chen, N.2
Glick, I.D.3
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Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
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J.A. Lieberman et al., "Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia," New England Journal of Medicine 353, no. 12 (2005): 1209-1223.
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Lieberman, J.A.1
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31
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Risk of Death in Elderly Users of Conventional vs. Atypical Antipsychotic Medications
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P.S. Wang et al., "Risk of Death in Elderly Users of Conventional vs. Atypical Antipsychotic Medications," New England Journal of Medicine 353, no. 22 (2005): 2335-2341.
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, pp. 2335-2341
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Wang, P.S.1
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0037075259
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Direct-to-Consumer Advertising - Strengthening Our Health Care System
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A.F. Holmer, "Direct-to-Consumer Advertising - Strengthening Our Health Care System" (Letter), New England Journal of Medicine 346, no. 7 (2002): 526-528.
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(2002)
New England Journal of Medicine
, vol.346
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Holmer, A.F.1
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4644332399
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Truth in Advertising: Rx Drug Ads Come of Age
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C. Rados, "Truth in Advertising: Rx Drug Ads Come of Age," FDA Consumer 38, no. 4 (2004): 20-27.
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(2004)
FDA Consumer
, vol.38
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, pp. 20-27
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Rados, C.1
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Consumers' Reports on the Health Effects of Direct-to-Consumer Drug Advertising
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published online 26 February 2003; 10.1377/hlthaff.w3.82
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J.S. Weissman et al., "Consumers' Reports on the Health Effects of Direct-to-Consumer Drug Advertising," Health Affairs 22 (2003): w82-w95 (published online 26 February 2003; 10.1377/hlthaff.w3.82).
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, vol.22
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Weissman, J.S.1
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4644250772
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Physicians Report on Patient Encounters Involving Direct-to-Consumer Advertising
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published online 28 April 2004; 10.1377/hlthaff.w4.219
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J.S. Weissman et al., "Physicians Report on Patient Encounters Involving Direct-to-Consumer Advertising," Health Affairs 23 (2004): w219-w233 (published online 28 April 2004; 10.1377/hlthaff.w4.219);
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, vol.23
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Weissman, J.S.1
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The Impact of Direct-to-Consumer Advertising
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and C. Lewis, "The Impact of Direct-to-Consumer Advertising," FDA Consumer 37, no. 2 (2003): 8.
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(2003)
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National Institute of Health Care Management Research and Educational Foundation, Prescription Drugs and Mass Media Advertising (Washington: NIHCM, 2000).
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Prescription Drugs and Mass Media Advertising
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43
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10344262548
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Effects of Pharmaceutical Promotion on Adherence to the Treatment Guidelines for Depression
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J.M. Donohue et al., "Effects of Pharmaceutical Promotion on Adherence to the Treatment Guidelines for Depression," Medical Care 42, no. 12 (2004): 1176-1185.
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Donohue, J.M.1
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Influence of Patients' Requests for Direct-to-Consumer Advertised Antidepressants: A Randomized Controlled Trial
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R.L. Kravitz et al., "Influence of Patients' Requests for Direct-to-Consumer Advertised Antidepressants: A Randomized Controlled Trial," Journal of the American Medical Association 293, no. 16 (2005): 1995-2002.
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Kravitz, R.L.1
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8344280939
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Does Medicaid Pay Too Much for Prescription Drugs? A Case Study of Atypical Antipsychotics
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April
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M.G. Duggan, "Does Medicaid Pay Too Much for Prescription Drugs? A Case Study of Atypical Antipsychotics," National Bureau of Economic Research Working Paper 9626, April 2003, http://www.nber.org/papers/w9626 (accessed 21 March 2006);
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National Bureau of Economic Research Working Paper 9626
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Duggan, M.G.1
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Pub. no. 7381, October
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J.S. Crowley, D. Ashner, and L. Elam, State Medicaid Outpatient Prescription Drug Policies: Findings from a National Survey, 2005 Update, Pub. no. 7381, October 2005, http://www.kff.org/medicaid/7381.cfm (accessed 13 February 2006).
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State Medicaid Outpatient Prescription Drug Policies: Findings from a National Survey, 2005 Update
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Crowley, J.S.1
Ashner, D.2
Elam, L.3
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