Benefits and harms of perioperative beta-blockade

Best Practice and Research: Clinical Anaesthesiology

Volumn 20, Issue 2, 2006, Pages 285-302

  Wetterslev, Jørn ^a   Juul, Anne Benedicte ^a  

^a Mental Health Services CPH   (Denmark)

Author keywords

adrenergic; beta blockers; cardiac surgical procedures; mortality; myocardial infarction; perioperative care; perioperative procedures; postoperative; surgery; surgical procedures

Indexed keywords

AMIODARONE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; CARVEDILOL; ESMOLOL; METOPROLOL; PLACEBO; SOTALOL;

BRADYCARDIA; BRONCHOSPASM; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DEATH; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSE REGIMEN; DRUG TOLERABILITY; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART SURGERY; HIGH RISK PATIENT; HUMAN; HYPOTENSION; INCIDENCE; META ANALYSIS; MORBIDITY; MORTALITY; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZATION; RESPIRATORY FAILURE; REVIEW; SEPSIS; STROKE; SURGICAL PATIENT; SYSTEMATIC REVIEW; TACHYCARDIA;

ADRENERGIC BETA-ANTAGONISTS; DIABETES MELLITUS; HUMANS; MYOCARDIAL INFARCTION; PERIOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; RESEARCH DESIGN;

EID: 33744546814     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2005.10.006     Document Type: Review

References (62)

1. Freemantle N., Cleland J., Young P., et al. Beta-blockade after myocardial infarction: systematic review and metaregression analysis. BMJ 318 7200 (1999) 1730-1737
2. Houghton T., Freemantle N., and Cleland J.G. Are beta-blockers effective in patients who develop heart failure soon after myocardial infarction? A meta-regression analysis of randomised trials. Eur J Heart Fail 2 3 (2000) 333-340
3. MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 353 (1999) 2001-2006
4. Heidenreich P.A., Lee T.T., and Massie B.M. Effects of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomised clinical trials. J Am Coll Card 30 1 (1997) 27-34
5. Lechat P., Packer M., Chalon S., et al. Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomised trials. Circulation 98 12 (1998) 1184-1191
6. Wikstrand J. Primary prevention with beta-blockade in patients with hypertension: review of results and clinical implications. J Card Vasc Pharmcol 16 supplement 5 (1990) 64-75
7. Ronnevik P.K. Predicting return to work after acute myocardial infarction. Significance of clinical data, exercise test variables and beta-blocker therapy. Cardiology. 75 3 (1988) 230-236
8. Priebe H.-J. Perioperative myocardial infarction-aetiology and prevention. Br J Anaesth 95 (2005) 3-19
9. Mangano D.T., Layug E.L., Wallace A., and Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med 335 23 (1996) 1713-1720
10. Poldermans D., Boersma E., Bax J.J., et al. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 341 24 (1999) 1789-1794
11. Stevens R.D., Burri H., and Tramer M.R. Pharmacologic myocardial protection in patients undergoing noncardiac surgery: a quantitative systematic review. Anesth Analg 97 3 (2003) 623-633
12. Yang H., Raymer K., Butler R., et al. Metoprolol after vascular surgery (MAVS). Can J Anesth 51 supplement 1 (2004) A7
13. Juul A.B., Wetterslev J., Kofoed-Enevoldsen A., et al. The Diabetic Postoperative Mortality and Morbidity (DIPOM) Trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. Am Heart J 147 4 (2004) 677-683
14. POBBLE Trial investigators. Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial. J Vasc Surg 41 (2005) 602-609
15. Lindenauer P.K., Pekow P., Wang K., et al. Perioperative beta-blocker therapy and mortality after major non-cardiac surgery. N Engl Med 353 (2005) 349-361
16. Devereaux P.J., Beattie W.S., and Choi P.T.-L. How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials. BMJ 331 (2005) 313-321
17. Crystal E, Garfinkle MS, Connolly SS et al. Interventions for preventing postoperative fibrillation in patients undergoing heart surgery. The Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD003611.pub2. DOI:10.10002/14651858.CD003611.pub2.
18. Shammash J.B., Trost J.C., Gold J.M., et al. Perioperative beta-blocker withdrawal and mortality in vascular surgical patients. Am Heart J 141 1 (2001) 148-153
19. Gilligan D.M., Chan W.L., Stewart R., et al. Adrenergic hypersensitivity after beta-blocker withdrawal in hypertrophic cardiomyopathy. Am J Cardiol 68 8 (1991) 766-772
20. O'Brien P.C., and Fleming T.R. A multiple testing procedure for clinical trials. Biometrics 35 3 (1979) 549-556
21. Kjaergard L.L., Villumsen J., and Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135 11 (2001) 982-989
22. Eagle K.A., Berger P.B., Calkins H., et al. ACC/AHA Guideline Update for Perioperative Cardiovascular Evaluation for Noncardiac Surgery-Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Anesth Analg 94 5 (2002) 1052-1064
23. Guidelines for Assessing and Managing the Perioperative Risk from Coronary Artery Disease Associated with Major Noncardiac Surgery. Ann Intern Med 1997; 127(4): 309-12.
24. Juul A.B., Wetterslev J., Gluud C., et al. Randomized, blinded trial on perioperative metoprolol vs. placebo for diabetic patients undergoing major noncardiac surgery. Circulation 111 (2005) 1725
25. Ferguson T.B., Commbs L.P., and Peterson E.D. Preoperative β-Blocker use and mortality and morbidity following CABG surgery in North America. JAMA 287 17 (2002) 2221-2227
26. Ten Broecke P.W.C., De Hert S.G., Mertens E., et al. Effect of preoperative β-Blockade on perioperative mortality in coronary surgery. Br J Anaesth 90 (2003) 27-31
27. Raby K.E., Brull S.J., Timimi F., et al. The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery. Anesth Analg 88 3 (1999) 477-482
28. Wallace A., Layug B., Tateo I., et al. Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group. Anesthesiology 88 1 (1998) 7-17
29. Stone J.G., Foex P., Sear J.W., et al. Myocardial ischemia in untreated hypertensive patients: effect of a single small oral dose of a beta-adrenergic blocking agent. Anesthesiology 68 4 (1988) 495-500
30. Dawood M.M., Gutpa D.K., Southern J., et al. Pathology of fatal perioperative myocardial infarction: implications regarding pathophysiology and prevention. Int J Cardiol 57 1 (1996) 37-44
31. Rabbani R., and Topol E.J. Strategies to achieve coronary arterial plaque stabilization. Cardiovasc Res 41 2 (1999) 402-417
32. Yeager R.A., Moneta G.L., Edwards J.M., et al. Reducing perioperative myocardial infarction following vascular surgery. The potential role of beta-blockade. Arch Surg 130 8 (1995) 869-872
33. Guvendik L., Davies M., and Parker D.J. Oral beta-blockade with hypothermic potassium cardioplegia in cardiac surgery: is there an additive protective effect?. Thor Cardiovasc Surg 34 1 (1986) 25-29
34. Cork R.C., Kramer T.H., Dreiscmeier B., et al. The effect of esmolol given during cardiopulmonary bypass. Anesth Analg 81 2 (1995) 429-430
35. Kuhn-Regnier F., Natour E., Dhein S., et al. beta-blockade versus Buckberg blood-cardioplegia in coronary bypass operation. Eur J Cardio Thor Surg 15 (1999) 67-74
36. Plosker G.L., and Clissold S.P. Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. Drugs 43 3 (1992) 382-414
37. Sandberg A., Abrahamsson B., Svenheden A., et al. Steady-state bioavailability of a multiple-unit (CR/ZOK) and a single-unit (OROS) delivery system of metoprolol after once-daily dosing. Pharm Res 10 1 (1993) 28-34
38. Wieselgren I., Lundborg P., Sandberg A., et al. Pharmakokinetic and pharmakodynamic evaluation of metoprolol controlled release (CR/Zok) 50 mg in young subjects. J Clin Pharmacol 30 2 (1990) 28-32
39. Omvik P., Leer J., Istad H., and Westergren. Equal efficacy and improved tolerability with 50 mg controlled-release metoprolol compared with 100 mg conventional metoprolol in hypertensive patients. Am J Ther 1 1 (1994) 65-73
40. Poole-Wilson P.A., Swedberg K., Cleland J.G.F., for the COMET Investigators, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 362 (2003) 7-13
41. Juul A.B., Wetterslev J., and Kofoed-Enevoldsen A. Long-term postoperative mortality in diabetic patients undergoing major non-cardiac surgery. Eur J Anaesthesiol 21 7 (2004) 523-529
42. Zaugg M., Tagliente T., Lucchinetti E., et al. Beneficial effects from beta-adrenergic blockade in elderly patients undergoing noncardiac surgery. Anesthesiology 91 6 (1999) 1674-1686
43. Davies M.J., Dysart R.H., Silbert B.S., et al. Prevention of tachycardia with atenolol pretreatment for carotid endarterectomy under cervical plexus blockade. Anaesth Intensive Care 20 2 (1992) 161-164
44. Bayliff C.D., Massel D.R., Inculet R.I., et al. Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery. Ann Thor Surg 67 1 (1999) 182-186
45. Jakobsen C.J., Bille S., Ahlburg P., et al. Perioperative metoprolol reduces the frequency of atrial fibrillation after thoracotomy for lung resection. J Cardiothor Vasc Anesth 11 6 (1997) 746-751
46. Pasternack P.F., Grossi E.A., Baumann F.G., et al. Beta blockade to decrease silent myocardial ischemia during peripheral vascular surgery. Am J Surg 158 2 (1989) 113-116
47. Moher D., Pham B., Jones A., et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 352 9128 (1998) 609-613
48. Schulz K.F., Chalmers I., Hayes R.J., et al. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273 5 (1995) 408-412
49. Pasternack P.F., Imparato A.M., Baumann F.G., et al. The hemodynamics of beta-blockade in patients undergoing abdominal aortic aneurysm repair. Circulation 76 3 Pt 2 (1987) III1-III7
50. Magnusson J., Thulin T., Werner O., et al. Haemodynamic effects of pretreatment with metoprolol in hypertensive patients undergoing surgery. Br J Anaesth 58 3 (1986) 251-260
51. Cucchiara R.F., Benefiel D.J., Matteo R.S., et al. Evaluation of esmolol in controlling increases in heart rate and blood pressure during endotracheal intubation in patients undergoing carotid endarterectomy. Anesthesiology 65 5 (1986) 528-531
52. Altman D.G., and Bland J.M. Interaction revisited: the difference between two estimates. BMJ 326 (2003) 219
53. Ioannidis, JPA. Why most published research findings are false. PLoS Medicine www.plosmedicine.org. 2005;8:e124.
54. Als-Nielsen B., Chen W., Gluud L.L., et al. Are trial size and quality associated with treatment effects in randomised trials? Observational study of 523 randomised trials. The 12th International Cochrane Colloquium (2004) 102-103
55. Sackett D., Haynes R., and Tugwell P. Deciding on the best therapy. Clinical Epidemiology: a Basic Science for clinical Medicine (1985), Little Brown, Boston, MA 171-197
56. Frishman W., and Cheng A. Secondary prevention of myocardial infarction: role of beta-adrenergic blockers and angiotensin-converting enzyme inhibitors. Am Heart J 137 4 (1999) 25-34
57. Devereaux P.J., Yusuf S., Yang H., et al. Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence?. CMAJ 171 3 (2004) 245-247
58. Devereaux P.J., Leslie K., and Yang H. The effect of perioperative beta-blockers on patients undergoing noncardiac surgery-is the answer in?. Can J Anaesth 51 8 (2004) 749-755
59. Wetterslev J., Thorlund K., Brok J., and Gluud C. Trial sequential analyses of six Cochrane Neonatal Review Group meta-analyses using actual information size (I). Clin Trials 2 supplement 1 (2005) 32-33
60. Brok J., Thorlund K., Gluud C., and Wetterslev J. Trial sequential analyses of six Cochrane Neonatal Review Group meta-analyses considering adequacy of allocation concealment (II). Clin Trials 2 supplement 1 (2005) 61-62
61. Thorlund K., Wetterslev J., Brok J., and Gluud C. Trial sequential analyses of six Cochrane Neonatal Review Group meta-analyses considering heterogeneity and trial weight (III). Clin Trials 2 supplement 1 (2005) 62 Abstract P36
62. Leslie K., and Devereaux P.J. A large trial is vital to prove perioperative beta-blockade effectiveness and safety before widespread use. Anesthesiology 101 3 (2004) 803-806