메뉴 건너뛰기




Volumn 135, Issue 1-2, 2006, Pages 45-53

Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16)

Author keywords

Bioactivity; C terminal truncation; Glucose dependent insulinotropic polypeptide (GIP); Obese diabetic ob ob mice

Indexed keywords

ANTIDIABETIC AGENT; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE [1-16]; GASTRIC INHIBITORY POLYPEPTIDE [1-16] 3 PROLINE; GASTRIC INHIBITORY POLYPEPTIDE [1-42]; GLUCOSE; HEMOGLOBIN A1C; UNCLASSIFIED DRUG;

EID: 33744544382     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2006.03.006     Document Type: Article
Times cited : (11)

References (26)
  • 1
    • 0344010130 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?
    • Gault V.A., O'Harte F.P., and Flatt P.R. Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?. Neuropeptides 37 5 (2003) 253-263
    • (2003) Neuropeptides , vol.37 , Issue.5 , pp. 253-263
    • Gault, V.A.1    O'Harte, F.P.2    Flatt, P.R.3
  • 2
    • 0030052774 scopus 로고    scopus 로고
    • GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells
    • Wang Y., Montrose-Rafizadeh C., Adams L., Raygada M., Nadiv O., and Egan J.M. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Mol Cell Endocrinol 116 1 (1996) 81-87
    • (1996) Mol Cell Endocrinol , vol.116 , Issue.1 , pp. 81-87
    • Wang, Y.1    Montrose-Rafizadeh, C.2    Adams, L.3    Raygada, M.4    Nadiv, O.5    Egan, J.M.6
  • 3
    • 0141785429 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
    • Ehses J.A., Casilla V.R., Doty T., Pospisilik J.A., Winter K.D., Demuth H.U., Pederson R.A., and McIntosh C.H. Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase. Endocrinology 144 10 (2003) 4433-4445
    • (2003) Endocrinology , vol.144 , Issue.10 , pp. 4433-4445
    • Ehses, J.A.1    Casilla, V.R.2    Doty, T.3    Pospisilik, J.A.4    Winter, K.D.5    Demuth, H.U.6    Pederson, R.A.7    McIntosh, C.H.8
  • 4
    • 0036687655 scopus 로고    scopus 로고
    • Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells
    • Trumper A., Trumper K., and Horsch D. Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. J Endocrinol 174 2 (2002) 233-246
    • (2002) J Endocrinol , vol.174 , Issue.2 , pp. 233-246
    • Trumper, A.1    Trumper, K.2    Horsch, D.3
  • 5
    • 0031930530 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle
    • O'Harte F.P.M., Gray A.M., and Flatt P.R. Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle. J Endocrinol 156 2 (1998) 237-243
    • (1998) J Endocrinol , vol.156 , Issue.2 , pp. 237-243
    • O'Harte, F.P.M.1    Gray, A.M.2    Flatt, P.R.3
  • 7
    • 0025808278 scopus 로고
    • Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36)amide, on fatty acid synthesis in explants of rat adipose tissue
    • Oben J., Morgan L.M., Fletcher J., and Marks V. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36)amide, on fatty acid synthesis in explants of rat adipose tissue. J Endocrinol 130 2 (1991) 267-272
    • (1991) J Endocrinol , vol.130 , Issue.2 , pp. 267-272
    • Oben, J.1    Morgan, L.M.2    Fletcher, J.3    Marks, V.4
  • 8
    • 0028855353 scopus 로고
    • Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat tissue
    • Knapper J.M., Puddicombe S.M., Morgan L.M., and Fletcher J.M. Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat tissue. J Nutr 125 2 (1995) 183-188
    • (1995) J Nutr , vol.125 , Issue.2 , pp. 183-188
    • Knapper, J.M.1    Puddicombe, S.M.2    Morgan, L.M.3    Fletcher, J.M.4
  • 9
    • 0034967893 scopus 로고    scopus 로고
    • The entero-insular axis in type 2 diabetes-incretins as therapeutic agents
    • Creutzfeldt W. The entero-insular axis in type 2 diabetes-incretins as therapeutic agents. Exp Clin Endocrinol Diabetes 109 S2 (2001) S288-S303
    • (2001) Exp Clin Endocrinol Diabetes , vol.109 , Issue.SUPPL.2
    • Creutzfeldt, W.1
  • 10
    • 0035810678 scopus 로고    scopus 로고
    • Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)
    • Hinke S.A., Manhart S., Pamir N., Demuth H., W Gelling R., Pederson R.A., and McIntosh C.H. Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP). Biochim Biophys Acta 1547 1 (2001) 143-155
    • (2001) Biochim Biophys Acta , vol.1547 , Issue.1 , pp. 143-155
    • Hinke, S.A.1    Manhart, S.2    Pamir, N.3    Demuth, H.4    W Gelling, R.5    Pederson, R.A.6    McIntosh, C.H.7
  • 11
    • 0242432370 scopus 로고    scopus 로고
    • Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide
    • Gault V.A., Harriott P., Flatt P.R., and O'Harte F.P.M. Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. Biosci Rep 22 5-6 (2002) 523-528
    • (2002) Biosci Rep , vol.22 , Issue.5-6 , pp. 523-528
    • Gault, V.A.1    Harriott, P.2    Flatt, P.R.3    O'Harte, F.P.M.4
  • 12
    • 0030009302 scopus 로고    scopus 로고
    • The insulinotropic region of gastric inhibitory polypeptide; fragment analysis suggests the bioactive site lies between residues 19 and 30
    • Morrow G.W., Kieffer T.J., McIntosh C.H., MacGillivray R.T., Brown J.C., St Pierre S., and Pederson R.A. The insulinotropic region of gastric inhibitory polypeptide; fragment analysis suggests the bioactive site lies between residues 19 and 30. Can J Physiol Pharmacol 74 1 (1996) 65-72
    • (1996) Can J Physiol Pharmacol , vol.74 , Issue.1 , pp. 65-72
    • Morrow, G.W.1    Kieffer, T.J.2    McIntosh, C.H.3    MacGillivray, R.T.4    Brown, J.C.5    St Pierre, S.6    Pederson, R.A.7
  • 13
    • 0242500960 scopus 로고    scopus 로고
    • Structure-function analysis of a series of novel GIP analogues containing different helical length linkers
    • Manhart S., Hinke S.A., McIntosh C.H., Pederson R.A., and Demuth H.U. Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. Biochemistry 42 10 (2003) 3081-3088
    • (2003) Biochemistry , vol.42 , Issue.10 , pp. 3081-3088
    • Manhart, S.1    Hinke, S.A.2    McIntosh, C.H.3    Pederson, R.A.4    Demuth, H.U.5
  • 14
    • 4043168530 scopus 로고    scopus 로고
    • In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide
    • Hinke S.A., Manhart S., Speck M., Pederson R.A., Demuth H.U., and McIntosh C.H. In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide. Life Sci 75 15 (2004) 1857-1870
    • (2004) Life Sci , vol.75 , Issue.15 , pp. 1857-1870
    • Hinke, S.A.1    Manhart, S.2    Speck, M.3    Pederson, R.A.4    Demuth, H.U.5    McIntosh, C.H.6
  • 15
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault V.A., Parker J.C., Harriott P., Flatt P.R., and O'Harte F.P.M. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol 175 2 (2002) 525-533
    • (2002) J Endocrinol , vol.175 , Issue.2 , pp. 525-533
    • Gault, V.A.1    Parker, J.C.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.M.5
  • 16
    • 0036289106 scopus 로고    scopus 로고
    • Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide
    • Gault V.A., O'Harte F.P.M., Harriott P., and Flatt P.R. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem Biophys Res Commun 290 5 (2002) 1420-1426
    • (2002) Biochem Biophys Res Commun , vol.290 , Issue.5 , pp. 1420-1426
    • Gault, V.A.1    O'Harte, F.P.M.2    Harriott, P.3    Flatt, P.R.4
  • 19
    • 0019471997 scopus 로고
    • Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice
    • Flatt P.R., and Bailey C.J. Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20 5 (1981) 573-577
    • (1981) Diabetologia , vol.20 , Issue.5 , pp. 573-577
    • Flatt, P.R.1    Bailey, C.J.2
  • 20
    • 0015038855 scopus 로고
    • Determination of glucose by an automatic analyser
    • Stevens J.F. Determination of glucose by an automatic analyser. Clin Chem Acta 32 2 (1971) 199-201
    • (1971) Clin Chem Acta , vol.32 , Issue.2 , pp. 199-201
    • Stevens, J.F.1
  • 23
    • 13944255558 scopus 로고    scopus 로고
    • A novel amino-terminally glycated analogue of glucose-dependent insulinotropic polypeptide (GIP), with a prolonged insulinotropic activity in type 2 diabetes mellitus
    • Lindsay J.R., Au S.T.B., Kelly C.M.N., O'Harte F.P.M., and Flatt P.R. A novel amino-terminally glycated analogue of glucose-dependent insulinotropic polypeptide (GIP), with a prolonged insulinotropic activity in type 2 diabetes mellitus. Diabetes S5 (2002) 1394
    • (2002) Diabetes , vol.S5 , pp. 1394
    • Lindsay, J.R.1    Au, S.T.B.2    Kelly, C.M.N.3    O'Harte, F.P.M.4    Flatt, P.R.5
  • 24
    • 0036383414 scopus 로고    scopus 로고
    • Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
    • O'Harte F.P., Gault V.A., Parker J.C., Harriott P., Mooney M.H., Bailey C.J., and Flatt P.R. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia 45 9 (2002) 1281-1291
    • (2002) Diabetologia , vol.45 , Issue.9 , pp. 1281-1291
    • O'Harte, F.P.1    Gault, V.A.2    Parker, J.C.3    Harriott, P.4    Mooney, M.H.5    Bailey, C.J.6    Flatt, P.R.7
  • 25
    • 0037299115 scopus 로고    scopus 로고
    • 3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic ob/ob mice: evidence that GIP is the major physiological incretin
    • 3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic ob/ob mice: evidence that GIP is the major physiological incretin. Diabetologia 46 2 (2003) 222-230
    • (2003) Diabetologia , vol.46 , Issue.2 , pp. 222-230
    • Gault, V.A.1    O'Harte, F.P.2    Harriott, P.3    Mooney, M.H.4    Green, B.D.5    Flatt, P.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.