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Volumn 407, Issue , 2006, Pages 575-597

Using Inhibitors of Prenylation to Block Localization and Transforming Activity

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; AGAR; ALX 290 005; FTI 2153; G 242; GERANYLGERANYLTRANSFERASE 1 INHIBITOR; GGTI 2166; GGTI 2417; GGTI 298; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; L 7287; L 774832; L 778123; LONAFARNIB; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TIPIFARNIB; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 33744524839     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)07046-1     Document Type: Review
Times cited : (26)

References (22)
  • 1
    • 25444481924 scopus 로고    scopus 로고
    • Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif
    • Berzat A.C., Buss J.E., Chenette E.J., Weinbaum C.A., Shutes A., Der C.J., Minden A., and Cox A.D. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J. Biol. Chem. 280 (2005) 33055-33065
    • (2005) J. Biol. Chem. , vol.280 , pp. 33055-33065
    • Berzat, A.C.1    Buss, J.E.2    Chenette, E.J.3    Weinbaum, C.A.4    Shutes, A.5    Der, C.J.6    Minden, A.7    Cox, A.D.8
  • 2
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey P.J., and Seabra M.C. Protein prenyltransferases. J. Biol. Chem. 271 (1996) 5289-5292
    • (1996) J. Biol. Chem. , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 3
    • 0027393663 scopus 로고
    • GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein
    • Chuang T.H., Xu X., Knaus U.G., Hart M.J., and Bokoch G.M. GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein. J. Biol. Chem. 268 (1993) 775-778
    • (1993) J. Biol. Chem. , vol.268 , pp. 775-778
    • Chuang, T.H.1    Xu, X.2    Knaus, U.G.3    Hart, M.J.4    Bokoch, G.M.5
  • 4
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox A.D., and Der C.J. Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?. Biochim. Biophys. Acta 1333 (1997) F51-F71
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 5
    • 0029097751 scopus 로고
    • Analysis of Ras protein expression in mammalian cells
    • Cox A.D., Solski P.A., Jordan J.D., and Der C.J. Analysis of Ras protein expression in mammalian cells. Methods Enzymol. 255 (1995) 195-220
    • (1995) Methods Enzymol. , vol.255 , pp. 195-220
    • Cox, A.D.1    Solski, P.A.2    Jordan, J.D.3    Der, C.J.4
  • 6
    • 0035067298 scopus 로고    scopus 로고
    • Mammalian expression vectors for Ras family proteins: Generation and use of expression constructs to analyze Ras family function
    • Fiordalisi J.J., Johnson II R.L., Ulku A.S., Der C.J., and Cox A.D. Mammalian expression vectors for Ras family proteins: Generation and use of expression constructs to analyze Ras family function. Methods Enzymol. 332 (2001) 3-36
    • (2001) Methods Enzymol. , vol.332 , pp. 3-36
    • Fiordalisi, J.J.1    Johnson II, R.L.2    Ulku, A.S.3    Der, C.J.4    Cox, A.D.5
  • 7
    • 0025073547 scopus 로고
    • Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
    • Fukumoto Y., Kaibuchi K., Hori Y., Fujioka H., Araki S., Ueda T., Kikuchi A., and Takai Y. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene 5 (1990) 1321-1328
    • (1990) Oncogene , vol.5 , pp. 1321-1328
    • Fukumoto, Y.1    Kaibuchi, K.2    Hori, Y.3    Fujioka, H.4    Araki, S.5    Ueda, T.6    Kikuchi, A.7    Takai, Y.8
  • 9
    • 0026496258 scopus 로고
    • A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs
    • Hart M.J., Maru Y., Leonard D., Witte O.N., Evans T., and Cerione R.A. A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs. Science 258 (1992) 812-815
    • (1992) Science , vol.258 , pp. 812-815
    • Hart, M.J.1    Maru, Y.2    Leonard, D.3    Witte, O.N.4    Evans, T.5    Cerione, R.A.6
  • 10
    • 0344412931 scopus 로고    scopus 로고
    • Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling
    • Joyce P.L., and Cox A.D. Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. Cancer Res. 63 (2003) 7959-7967
    • (2003) Cancer Res. , vol.63 , pp. 7959-7967
    • Joyce, P.L.1    Cox, A.D.2
  • 11
    • 27744490370 scopus 로고    scopus 로고
    • Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells
    • Keller P.K., Fiordalisi J.J., Berzat A.C., and Cox A.D. Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells. Methods 37 (2005) 131-137
    • (2005) Methods , vol.37 , pp. 131-137
    • Keller, P.K.1    Fiordalisi, J.J.2    Berzat, A.C.3    Cox, A.D.4
  • 12
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R., Solski P.A., Clark G.J., Kinch M.S., and Der C.J. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15 (1995) 6443-6453
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 13
    • 0029084993 scopus 로고
    • Solubilization of Cdc42Hs from membranes by Rho-GDP dissociation inhibitor
    • Leonard D.A., and Cerione R.A. Solubilization of Cdc42Hs from membranes by Rho-GDP dissociation inhibitor. Methods Enzymol. 256 (1995) 98-105
    • (1995) Methods Enzymol. , vol.256 , pp. 98-105
    • Leonard, D.A.1    Cerione, R.A.2
  • 14
    • 0028981375 scopus 로고
    • Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid
    • Marom M., Haklai R., Ben-Baruch G., Marciano D., Egozi Y., and Kloog Y. Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. J. Biol. Chem. 270 (1995) 22263-22270
    • (1995) J. Biol. Chem. , vol.270 , pp. 22263-22270
    • Marom, M.1    Haklai, R.2    Ben-Baruch, G.3    Marciano, D.4    Egozi, Y.5    Kloog, Y.6
  • 15
    • 0035825193 scopus 로고    scopus 로고
    • Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
    • Michaelson D., Silletti J., Murphy G., D'Eustachio P., Rush M., and Philips M.R. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding. J. Cell Biol. 152 (2001) 111-126
    • (2001) J. Cell Biol. , vol.152 , pp. 111-126
    • Michaelson, D.1    Silletti, J.2    Murphy, G.3    D'Eustachio, P.4    Rush, M.5    Philips, M.R.6
  • 16
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • Qiu R.G., Chen J., Kirn D., McCormick F., and Symons M. An essential role for Rac in Ras transformation. Nature 374 (1995) 457-459
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 18
    • 2342508517 scopus 로고    scopus 로고
    • Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP
    • Rotblat B., Niv H., Andre S., Kaltner H., Gabius H.J., and Kloog Y. Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res. 64 (2004) 3112-3118
    • (2004) Cancer Res. , vol.64 , pp. 3112-3118
    • Rotblat, B.1    Niv, H.2    Andre, S.3    Kaltner, H.4    Gabius, H.J.5    Kloog, Y.6
  • 19
    • 1342331479 scopus 로고    scopus 로고
    • Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
    • Sebti S.M., and Der C.J. Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat. Rev. Cancer 3 (2003) 945-951
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 945-951
    • Sebti, S.M.1    Der, C.J.2
  • 20
    • 0034722890 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
    • Sebti S.M., and Hamilton A.D. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies. Oncogene 19 (2000) 6584-6593
    • (2000) Oncogene , vol.19 , pp. 6584-6593
    • Sebti, S.M.1    Hamilton, A.D.2
  • 21
    • 0035878110 scopus 로고    scopus 로고
    • Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1
    • Tao W., Pennica D., Xu L., Kalejta R.F., and Levine A.J. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 15 (2001) 1796-1807
    • (2001) Genes Dev. , vol.15 , pp. 1796-1807
    • Tao, W.1    Pennica, D.2    Xu, L.3    Kalejta, R.F.4    Levine, A.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.