Increased expression of high mobility group A proteins in lung cancer

Journal of Pathology

Volumn 209, Issue 2, 2006, Pages 206-212

  Sarhadi, V K ^a   Wikman, H ^a,b   Salmenkivi, K ^a,c   Kuosma, E ^a   Sioris, T ^d   Salo, J ^d   Karjalainen, A ^a   Knuutila, S ^c   Anttila, Sisko ^a,c  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF HELSINKI   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

HMGA1; HMGA2; Immunohistochemistry; Lung cancer; Survival; Tissue microarray

Indexed keywords

HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1A PROTEIN; HIGH MOBILITY GROUP A1B PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; ISOPROTEIN; MESSENGER RNA; TUMOR MARKER;

ADULT; AGED; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEASIBILITY STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SURVIVAL TIME; TRANSCRIPTION REGULATION;

AGED; APOPTOSIS; CARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; FEMALE; HMGA PROTEINS; HMGA1A PROTEIN; HMGA1B PROTEIN; HMGA2 PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE ARRAY ANALYSIS;

EID: 33744501010     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1960     Document Type: Article

References (23)

1. Sgarra R, Rustighi A, Tessari MA, Di Bernardo J, Altamura S, Fusco A, et al. Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer. FEBS Lett 2004;574:1-8.
2. Chiappetta G, Tallini G, De Biasio MC, Manfioletti G, Martinez-Tello FJ, Pentimalli F, et al. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 1998;58:4193-4198.
3. Abe N, Watanabe T, Sugiyama M, Uchimura H, Chiappetta G, Fusco A, et al. Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker. Cancer Res 1999;59:1169-1174.
4. Masciullo V, Baldassarre G, Pentimalli F, Berlingieri MT, Boccia A, Chiappetta G, et al. HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas. Carcinogenesis 2003;24:1191-1198.
5. Chiappetta G, Botti G, Monaco M, Pasquinelli R, Pentimalli F, Di Bonito M, et al. HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res 2004;10:7637-7644.
6. Trapasso F, Sarti M, Cesari R, Yendamuri S, Dumon KR, Aqeilan RI, et al. Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models. Cancer Gene Ther 2004;11:633-641.
7. Rogalla P, Drechsler K, Frey G, Hennig Y, Helmke B, Bonk U, et al. HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors. Am J Pathol 1996;149:775-779.
8. Miyazawa J, Mitoro A, Kawashiri S, Chada KK, Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res 2004;64:2024-2029.
9. Kayser K, Dunnwald D, Kazmierczak B, Bullerdiek J, Kaltner H, Zick Y, et al. Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas. Pathol Res Pract 2003;999:589-598.
10. Rogalla P, Drechsler K, Schroder-Babo W, Eberhardt K, Bullerdiek J. HMGIC expression patterns in non-small cell lung cancer and surrounding tissue. Anticancer Res 1998;18:3327-3330.
11. Wikman H, Kettunen E, Seppanen JK, Karjalainen A, Hollmen J, Anttila S, et al. Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array. Oncogene 2002;21:5804-5813.
12. Kettunen E, Anttila S, Seppanen JK, Karjalainen A, Edgren H, Lindstrom I, et al. Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer. Cancer Genet Cytogenet 2004;149:98-106.
13. Wikman H, Seppanen JK, Sarhadi VK, Kettunen E, Salmenkivi K, Kuosma E, et al. Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. J Pathol 2004;203:584-593.
14. Bamberger AM, Makrigiannakis A, Roser K, Radde J, Carstens T, Flohr AM, et al. Expression of the high-mobility group protein HMGI(Y) in human trophoblast: potential role in trophoblast invasion of maternal tissue. Virchows Arch 2003;443:649-654.
15. Chang ZG, Yang LY, Wang W, Peng JX, Huang GW, Yao YM, et al. Determination of high mobility group A1 (HMGA1) expression in hepatocellular carcinoma: a potential prognostic marker. Dig Dis Sci 2005;50:1764-1770.
16. Tamimi Y, van der Poel HG, Karthaus HF, Debruyne FM, Schalken JA. A retrospective study of high mobility group protein I(Y) as progression marker for prostate cancer determined by in situ hybridization. Br J Cancer 1996;74:573-578.
17. Langelotz C, Schmid P, Jakob C, Heider U, Wernecke KD, Possinger K, et al. Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer. Br J Cancer 2003;88:1406-1410.
18. Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 2002;376:771-774.
19. Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, et al. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol 2003;23:9104-9116.
20. Bandiera A, Bonifacio D, Manfioletti G, Mantovani F, Rustighi A, Zanconati F, et al. Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix. Cancer Res 1998;58:426-431.
21. Edberg DD, Adkins JN, Springer DL, Reeves R. Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteins. J Biol Chem 2005;280:8961-8973.
22. Chen X, Lechago J, Ertan A, Ergun G, Verm R, Bridges M, et al. Expression of the high mobility group proteins HMGI(Y) correlates with malignant progression in Barrett's metaplasia. Cancer Epidemiol Biomarkers Prev 2004;13:30-33.
23. Chiappetta G, Manfioletti G, Pentimalli F, Abe N, Di Bonito M, Vento MT, et al. High mobility group HMGI(Y) protein expression in colorectal hyperplastic and neoplastic diseases. Int J Cancer 2001;91:147-151.