Determination of high mobility group A1 (HMGA1) expression in hepatocellular carcinoma: A potential prognostic marker

Digestive Diseases and Sciences

Volumn 50, Issue 10, 2005, Pages 1764-1770

  Chang, Zhi Gang ^a   Yang, Lian Yue ^a   Wang, Wei ^a   Peng, Ji Xiang ^a   Huang, Gen Wen ^a   Tao, Yi Ming ^a   Ding, Xiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; HMGA1; Immunohistochemistry; Prognosis; RT PCR

Indexed keywords

HIGH MOBILITY GROUP A1A PROTEIN; MESSENGER RNA; PROTEIN;

ARTICLE; CANCER INVASION; CANCER PATIENT; CANCER RECURRENCE; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENESIS; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; GENE EXPRESSION; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL CARCINOMA; MALE; METASTASIS; PATHOGENESIS; PRECANCER; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME;

CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HMGA PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; RNA, MESSENGER; SURVIVAL RATE;

EID: 26244454626     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2934-9     Document Type: Article

References (45)

1. Bustin M, Lehn DA, Landsman D: Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta 1049:231-243, 1990
2. Reeves R, Nissen MS: The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem 265:8573-8582, 1990
3. Johnson KR, Cook SA, Davisson MT: Chromosomal localization of the murine gene and two related sequences encoding high-mobility-group I and Y proteins. Genomics 12:503-509, 1992
4. Johnson KR, Lehn DA, Elton TS, Barr PJ, Reeves R: Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem 263:18338-18342, 1988
5. Friedmann M, Holth LT, Zoghbi HY, Reeves R: Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res 21:4259-4267, 1993
6. Patel UA, Bandiera A, Manfioletti G, Giancotti V, Chau KY, Crane-Robinson C: Expression and cDNA cloning of human HMGI-C phosphoprotein. Biochem Biophys Res Commun 201:63-70, 1994
7. Thanos D, Maniatis T: The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell 71:777-789, 1992
8. Du W, Thanos D, Maniatis T: Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74:887-898, 1993
9. Lewis H, Kaszubska W, DeLamarter JF, Whelan J: Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol Cell Biol 14:5701-5709, 1994
10. Reeves R, Beckerbauer L: HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta 1519:13-29, 2001
11. Reeves R: Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277:63-81, 2001
12. Zhou X, Benson KF, Ashar HR, Chada K: Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376:771-774, 1995
13. Chiappetta G, Avantaggiato V, Visconti R, Fedele M, Battista S, Trapasso F, Merciai BM, Fidanza V, Giancotti V, Santoro M, Simeone A, Fusco A: High level expression of the HMGI (Y) gene during embryonic development. Oncogene 13:2439-2446, 1996
14. Chiappetta G, Bandiera A, Berlingieri MT, Visconti R, Manfioletti G, Battista S, Martinez-Tello FJ, Santoro M, Giancotti V, Fusco A: The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene 10:1307-14, 1995
15. Chiappetta G, Tallini G, De Biasio MC, Manfioletti G, Martinez-Tello FJ, Pentimalli F, de Nigris F, Mastro A, Botti G, Fedele M, Berger N, Santoro M, Giancotti V, Fusco A: Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 58:4193-1198, 1998
16. Tamimi Y, van der Poel HG, Denyn MM, Umbas R, Karthaus HF, Debruyne FM, Schalken JA: Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res 53:5512-5516, 1993
17. Tamimi Y, van der Poel HG, Karthaus HF, Debruyne FM, Schalken JA: A retrospective study of high mobility group protein I(Y) as progression marker for prostate cancer determined by in situ hybridization. Br J Cancer 74:573-578, 1996
18. Takaha N, Resar LM, Vindivich D, Coffey DS: High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells. Prostate 60:160-167, 2004
19. Fedele M, Bandiera A, Chiappetta G, Battista S, Viglietto G, Manfioletti G, Casamassimi A, Santoro M, Giancotti V, Fusco A: Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins. Cancer Res 56:1896-1901, 1996
20. Abe N, Watanabe T, Sugiyama M, Uchimura H, Chiappetta G, Fusco A, Atomi Y: Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker. Cancer Res 59:1169-1174, 1999
21. Kim DH, Park YS, Park CJ, Son KC, Nam ES, Shin HS. Expression of the HMGI(Y) gene in human colorectal cancer. Int J Cancer 84:376-80, 1999
22. Abe N, Watanabe T, Masaki T, Mori T, Sugiyama M, Uchimura H, Fujioka Y, Chiappetta G, Fusco A, Atomi Y: Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins. Cancer Res 60:3117-3122, 2000
23. Abe N, Watanabe T, Izumisato Y, Masaki T, Mori T, Sugiyama M, Chiappetta G, Fusco A, Fujioka Y, Atomi Y: Diagnostic significance of high mobility group I(Y) protein expression in intraductal papillary mucinous tumors of the pancreas. Pancreas 25:198-204, 2002
24. Bandiera A, Bonifacio D, Manfioletti G, Mantovani F, Rustighi A, Zanconati F: Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix. Cancer Res 58:426-131, 1998
25. Masciullo V, Baldassarre G, Pentimalli F, Berlingieri MT, Boccia A, Chiappetta G: HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas. Carcinogenesis 24:1191-1198, 2003
26. Nam ES, Kim DH, Cho SJ, Chae SW, Kim HY, Kim SM, Han, JJ, Shin HS, Park YE: Expression of HMGI(Y) associated with malignant phenotype of human gastric tissue. Histopathology 42:466-471, 2003
27. Liu WM, Guerra-Vladusic FK, Kurakata S, Lupu R, Kohwi-Shigematsu T: HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype. Cancer Res 59:5695-5703, 1999
28. Bosch FX, Ribes J, Borras J: Epidemiology of primary liver cancer. Semin Liver Dis 19:271-285, 1999
29. Okuda K: Hepatocellular carcinoma. J Hepatol 32:225-237, 2000
30. Pisani P, Parkin DM, Bray F, Ferlay J: Estimates of the worldwide mortality from 25 cancers in 1990 Int J Cancer 83:18-29, 1999
31. Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, Yeung C, Wong J: Hepatectomy for hepatocellular carcinoma: toward zero hospital death. Ann Surg 229:322-330, 1999
32. Tung-Ping Poon R, Fan ST, Wong J: Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 232:10-24, 2000
33. Wang W, Yang LY, Huang GW, Lu WQ, Yang ZL, Yang JQ, Liu HL: Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer 90:2349-2355, 2004
34. Edmondson HA, Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 7:462-503, 1954
35. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 396:643-649, 1998
36. Pienta KJ, Partin AW, Coffey DS: Cancer as a disease of DNA organization and dynamic cell structure. Cancer Res 49:2525-2532, 1989
37. Nowell PC: The clonal evolution of tumor cell populations. Science 194:23-28, 1976
38. Takaha N, Hawkins AL, Griffin CA, Isaacs WB, Coffey DS: High mobility group protein I(Y): A candidate architectural protein for chromosomal rearrangements in prostate cancer cells. Cancer Res 62:647-651, 2002
39. Reeves R, Edberg DD, Li Y: Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 21:575-594, 2001
40. Abe N, Watanabe T, Izumisato Y, Suzuki Y, Masaki T, Mori T, Sugiyama M, Fusco A, Atomi Y: High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: Its potential use in the diagnosis of liver neoplasms. J Gastroenterol 38:1144-1149, 2003
41. Holth LT, Thorlacius AE, Reeves R: Effects of epidermal growth factor and estrogen on the regulation of the HMG-I/Y gene in human mammary epithelial cell lines. DNA Cell Biol 16:1299-1309, 1997
42. Ram TG, Reeves R, Hosick HL: Elevated high mobility group-I(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells. Cancer Res 53:2655-2660, 1993
43. Lanahan A, Williams JB, Sanders LK, Nathans D: Growth factor-induced delayed early response genes. Mol Cell Biol 12:3919-3929, 1992
44. Ji YS, Xu Q, Schmedtje JF Jr: Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium. Circ Res 83:295-304, 1998
45. Thanos D, Maniatis T: Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83:1091-1100, 1995