DC-SIGN association with the Th2 environment of lepromatous lesions: Cause or effect?

Journal of Pathology

Volumn 209, Issue 2, 2006, Pages 182-189

  Soilleux, E J ^a,b,c   Sarno, E N ^d   Hernandez, M O ^d   Moseley, E ^a   Horsley, J ^a   Lopes, U G ^e   Goddard, M J ^a   Vowler, S L ^f   Coleman, N ^b   Shattock, R J ^g   Sampaio, E P ^d  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

DC SIGN; Leprosy; M. leprae; Macrophage; ManLAM

Indexed keywords

CELL RECEPTOR; LECTIN; LIPOARABINOMANNAN;

ADULT; ARTICLE; BACTERIAL CELL WALL; BACTERIAL TRANSMISSION; BORDERLINE LEPROSY; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; LEPROMATOUS LEPROSY; MACROPHAGE; MALE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH2 CELL; TUBERCULOID LEPROSY;

ADULT; ANTIGENS, BACTERIAL; CELL ADHESION MOLECULES; CELL LINE; CULTURE MEDIA; FEMALE; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HUMANS; LECTINS, C-TYPE; LEPROSY; LEPROSY, BORDERLINE; LEPROSY, TUBERCULOID; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MIDDLE AGED; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, CELL SURFACE; TH2 CELLS; TRANSFECTION;

EID: 33744493128     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1972     Document Type: Article

References (27)

1. Sieling PA, Modlin RL. Cytokine patterns at the site of mycobacterial infection. Immunobiology 1994;191(4-5):378-387.
2. Modlin RL. Thl-Th2 paradigm: insights from leprosy. J Invest Dermatol 1994;102(6):828-832.
3. Soilleux EJ, Morris LS, Leslie G, Chehimi J, Luo Q, Levroney E, et al. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol 2002;71(3):445-457.
4. Vermi W, Bonecchi R, Facchetti F, Bianchi D, Sozzani S, Festa S, et al. Recruitment of immature plasmacytoid dendritic cells (plasma-cytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas. J Pathol 2003;200(2):255-268.
5. Granelli-Piperno A, Pritsker A, Pack M, Shimeliovich I, Arrighi JF, Park CG, et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. J Immunol 2005;175(7):4265-4273.
6. Geijtenbeek TB, van Kooyk Y. Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity. APMIS 2003;111(7-8):698-714.
7. Colmenares M, Corbi AL, Turco SJ, Rivas L. The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J Immunol 2004;172(2):1186-1190.
8. Appelmelk BJ, van Die I, van Vliet SJ, Vandenbroucke-Grauls CM, Geijtenbeek TB, van Kooyk Y. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol 2003;170(4):1635-1639.
9. Cambi A, Gijzen K, de Vries JM, Torensma R, Joosten B, Adema GJ, et al. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Ear J Immunol 2003;33(2):532-538.
10. Maeda N, Nigou J, Herrmann JL, Jackson M, Amara A, Lagrange PH, et al. The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J Biol Chem 2003;278(8):5513-5516.
11. Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M, Amara A, et al. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 2003;197(1):121-127.
12. Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, et al. The human CDI-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens. J Immunol 2005;174(5):2637-2644.
13. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, et al. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med 2005;11(6):653-660.
14. Becker Y. The changes in the T helper 1 (Thl) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers - a review and hypothesis. Virus Genes 2004;28(1):5-18.
15. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Mycobact Dis 1966;34(3):255-273.
16. Wu L, Martin TD, Carrington M, KewalRamani VN. Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission. Virology 2004;318(1):17-23.
17. Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, et al. cis-Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor. J Virol 2001;75(24):12 028-12038.
18. Sampaio EP, Caneshi JR, Nery JA, Duppre NC, Pereira GM, Vieira LM, et al. Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virus-infected individuals. Infect Immun 1995;63(5):1848-1854.
19. Soilleux EJ, Morris LS, Lee B, Pohlmann S, Trowsdale J, Doms RW, et al. Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J Pathol 2001;195(5):586-592.
20. Soilleux EJ, Morris LS, Trowsdale J, Coleman N, Boyle JJ. Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages. J Pathol 2002;198(4):511-516.
21. Cuevas-Santos J, Contreras F, McNutt NS. Multibacillary leprosy: lesions with macrophages positive for Sl00 protein and dendritic cells positive for Factor 13a. J Cutan Pathol 1998;25(10):530-537.
22. Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997;90(9):3245-3287.
23. Romagnani S. T-cell subsets (Thl vs Th2). Ann Allerg Asthma Immunol 2000;85(1):9-18; quiz 18, 21.
24. Jullien D, Sieling PA, Uyemura K, Mar ND, Rea TH, Modlin RL. IL-15, an immunomodulator of T cell responses in intracellular infection. J Immunol 1997;158(2):800-806.
25. Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on l9pl3. J Immunol 2000;165(6):2937-2942.
26. Geijtenbeek TB, Van Vliet SJ, Koppel EA, Sanchez-Hernandez M, Vandenbroucke-Grauls CM, Appelmelk B, et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med 2003;197(1):7-17.
27. Nery JA, Sampaio EP, Galhardo MC, Perisse AR, Vieira LM, Salles AM, et al. M. Leprae-HIV co-infection: pattern of immune response in vivo and in vitro. Indian J Lepr 2000;72(2):155-167.