Transient antiphospholipid antibodies associated with acute infections in children: A report of three cases and a review of the literature

European Journal of Pediatrics

Volumn 165, Issue 7, 2006, Pages 484-488

  Mizumoto, H ^a   Maihara, T ^b   Hiejima, E ^c   Shiota, M ^a   Hata, A ^a   Seto, S ^c   Atsumi, T ^d   Koike, T ^d   Hata, D ^a  

^a Kitano Hospital   (Japan)

^b Hyogo Prefectural Tsukaguchi Hospital   (Japan)

^c Kishiwada City Hospital   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Bleeding complications; Hypoprothrombinemia; Lupus anticoagulant; Phosphatidylserine dependent antiprothrombin antibodies

Indexed keywords

ANTINUCLEAR ANTIBODY; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; LUPUS ANTICOAGULANT; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; PROTHROMBIN ANTIBODY;

ACUTE GASTROENTERITIS; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLEEDING TENDENCY; CASE REPORT; CHILD; CHILDHOOD DISEASE; CYTOMEGALOVIRUS INFECTION; DIARRHEA; ECCHYMOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEBRILE CONVULSION; FEMALE; FEVER; HUMAN; HYPOPROTHROMBINEMIA; INFANT; INFECTION; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RESPIRATORY TRACT INFECTION; SYMPTOM; VOMITING;

ACUTE DISEASE; ANTIBODIES, ANTIPHOSPHOLIPID; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT; INFECTION; LUPUS COAGULATION INHIBITOR; MALE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME;

EID: 33744486358     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-006-0117-0     Document Type: Article

References (29)

1. Arvieux J, Darnige L, Caron C, Reber G, Bensa JC, Colomb MG (1995) Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulant. Thromb Haemost 74:1120-1125
2. Atsumi T, Ieko M, Bertolaccini ML, Ichikawa K, Tsutsumi A, Matsuura E, Koike T (2000) Association of autoantibodies against the phosphatidylserine- prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 43:1982-1993
3. Bajaj SP, Rapaport SI, Barclay S, Herbst KD (1985) Acquired hypoprothrombinemia due to non-neutralizing antibodies to prothrombin: mechanism and management. Blood 65:1538-1543
4. Bajaj SP, Rapaport SI, Fierer DS, Herbst KD, Schwartz DB (1983) A mechanism for the hypoprothrombinemia of the acquired hypoprothombinemia-lupus anticoagulant syndrome. Blood 61:684-692
5. Becton DL, Stine KC (1997) Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. J Pediatr 130:998-1000
6. Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RFA (1991) Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost 66:629-632
7. Brandt JT, Triplett DA, Alving B, Scharrer I (1995) Criteria for the diagnosis of lupus anticoagulant: an update. Thromb Haemost 74:1185-1190
8. Eberhard A, Sparling C, Sudbury S, Peter F, Ronald L, Earl S (1994) Hypoprothrombinemia in childhood systemic lupus erythematosus. Semin Arthritis Rheum 24:12-18
9. Galli M, Beretta G, Daldossi M, Bevers EM, Barbui T (1997) Different anticoagulant and immunological properties of antiprothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost 77:486-491
10. Grau E, Real E, Pastor E, Ivorra J, Quecedo E (1997) Prothrombin deficiency and hemorrhage associated with a lupus anticoagulant. Am J Hematol 54:85
11. Harris EN, Gharavi AE, Patel SP, Hughes GR (1987) Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol 68:215-222
12. Helene CFC, David GH, John WU, Louis DW, Ross TAM (1997) A new method for characterization and epitope determination of a lupus anticoagulant-associated neutralizing antiprothrombin antibody. Am J Clin Pathol 107:196-204
13. Houbouyan L, Armengaud D, Leroy B, Roussi J, Gallet JP, Goguel A (1984) Antiprothrombinase anticoagulant and acquired prothrombin deficiency in childhood viral pathology. Spontaneous recovery. Arch Fr Pediatr 41:411-420
14. Hudson N, Duffy CM, Rauch J, Paquin JD, Esdaile JM (1997) Catastrophic haemorrhage in a case of pediatric primary antiphospholipid syndrome and factor II deficiency. Lupus 6:68-71
15. Humphries JE, Acker MN, Pinkston JE, Ruddy S (1994) Transient lupus anticoagulant associated with prothrombin deficiency: unusual case of bleeding in a 5-year-old girl. Am J Pediatr Hematol Oncol 16:372-376
16. Jaeger U, Kapiotis S, Pabinger I, Puchhammer E, Kyrle PA, Lechner K (1993) Transient lupus anticoagulant associated with hypoprothrombinemia and factor XII deficiency following adenovirus infection. Ann Hematol 67:95-99
17. Bernini JC, Buchanan GR, Ashcraft J (1993) Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant. J Pediatr 123:937-939
18. Khamashta MA, Hughes GR (1995) Antiphospholipid antibodies and antiphospholipid syndrome. Curr Opin Rheumatol 7:389-394
19. Lillquist KB, Dyerberg J, Krogh-Jensen M (1978) The absence of factor II in a child with systemic lupus erythematosus. Acta Paediatr Scand 67:533-536
20. Male C, Lechner K, Eichinger S, Kyrle PA, Kapiotis S, Wank H, Kaider A, Pabinger I (1999) Clinical significance of lupus anticoagulants in children. J Pediatr 134:199-205
21. Lee MT, Nardi MA, Hadzi-Nesic J, Karpatkin M (1996) Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1 1/2-year-old girl: report of a case and review of the literature. Am J Hematol 51:307-314
22. Bernstein ML, Salusinsky-Sternbach M, Bellefleur M, Esseltine DW (1984) Thrombotic and hemorrhagic complications in children with the lupus anticoagulant. Am J Dis Child 138:1132-1135
23. Schmugge M, Tolle S, Marbet GA, Laroche P, Meili EO (2001) Gingival bleeding, epistaxis and hematoma three days after gastroenteritis: the haemorrhagic lupus anticoagulant syndrome. Eur J Pediatr 160:43-46
24. Matsuda J, Saitoh N, Gotoh M, Kawasugi K, Gohchi K, Tsukamoto M (1996) Phosphatidyl serine-dependent antiprothrombin antibody is exclusive to patients with lupus anticoagulant. Br J Rheumatol 35:589-591
25. Matsuura E, Igarashi Y, Fujimoto M, Ichilawa K, Suzuki T, Sumida T, Yasuda T, Koike T (1992) Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol 148:3885-3891
26. Galli M, Barbui T (1999) Antiprothrombin antibodies: detection and clinical significance in the antiphospholipid syndrome. Blood 93:2149-2157
27. Shwartz S, Esseltine DW (1984) Postextraction haemorrhage in a young male patient with systemic lupus erythematosus. Oral Surg Oral Med Oral Pathol 57:254-257
28. Baca V, Montiel G, Meillon L, Pizzuto J, Catalan T, Juan-Shum L, Nieva B (2002) Diagnosis of lupus anticoagulant in the lupus anticoagulant- hypoprothrombinemia syndrome: report of two cases and review of the literature. Am J Hematol 71:200-207
29. Yacobvish JR, Uziel Y, Friedman Z, Radnay J, Wolach B (2001) Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome. Rheumatology 40:585-587