Diagnosis of lupus anticoagulant in the lupus anticoagulant-hypoprothrombinemia syndrome: Report of two cases and review of the literature

American Journal of Hematology

Volumn 71, Issue 3, 2002, Pages 200-207

  Baca, Vicente ^a   Montiel, Guadalupe ^b   Meillón, Luis ^a   Pizzuto, Javier ^a   Catalán, Teresa ^a   Juan Shum, Luis ^a   Nieva, Beatriz ^a  

^a HOSPITAL DE PEDIATRÍA   (Mexico)

^b HOSPITAL DE ESPECIALIDADES   (Mexico)

Author keywords

Hypoprothrombinemia; Lupus anticoagulant; Systemic lupus erythematosus

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; CORTICOSTEROID; LUPUS ANTICOAGULANT; PHOSPHOLIPID; PROTHROMBIN ANTIBODY; VIPER VENOM;

ADOLESCENT; ARTICLE; BIOASSAY; BLEEDING; BLOOD CLOTTING TEST; CASE REPORT; CLINICAL FEATURE; DEVICE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; EPISTAXIS; FEMALE; HEMATURIA; HUMAN; HUMAN TISSUE; HYPOPROTHROMBINEMIA; MALE; MENORRHAGIA; PRIORITY JOURNAL; SCHOOL CHILD; SYMPTOM; SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; VAGINA BLEEDING;

ADOLESCENT; ANTIBODIES; ANTIBODIES, ANTICARDIOLIPIN; BETA 2-GLYCOPROTEIN I; CHILD; FEMALE; GLYCOPROTEINS; HEMORRHAGE; HUMANS; HYPOPROTHROMBINEMIAS; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; SYNDROME;

EID: 0036830483     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10194     Document Type: Article

References (43)

1. Eberhard A, Sparling C, Sudbury S, Ford P, Laxer R, Silverman E. Hypoprothrombinemia in childhood systemic lupus erythematosus. Semin Arthritis Rheum 1994;24:12-18.
2. Lee MT, Nardi MA, Hu G, Hadzi-Nesic J, Karpatkin M. Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1 1/2-year-old girl: Report of a case and review of the literature. Am J Hematol 1996;51:307-314.
3. Vivaldi P, Rossetti G, Galli M, Finazzi G. Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. Case report and review of literature. Haematologica 1997;82:345-347.
4. Erkan D, Bateman H, Lockshin MD. Lupus anticoagulanthypoprothrombinemia syndrome associated with systemic lupus erythematosus: Report of 2 cases and review of literature. Lupus 1999;8:560-564.
5. Cabral AR, Cabiedes J, Alarcón-Segovia D. Antibodies to phospholipid-free β2-glycoprotein-I in patients with primary antiphospholipid syndrome. J Rheumatol 1995;22:1894-1898.
6. Arvieux J, Dranige L, Caron C, Reber G, Bensa JC, Colomb MG. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulants. Thromb Haemost 1995;74:1120-1125.
7. Galli M, Barbui T. Antiprothrombin antibodies: Detection and clinical significance in the antiphospholipid syndrome. Blood 1999;93:2149-2157.
8. Love PE, Santoro SA. Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Ann Intern Med 1990;12:682-698.
9. Rapaport SI, Ames SB, Duvall BJ. A plasma coagulation defect in systemic lupus erythematosus arising from hypoprothrombinemia combined with anti-prothrombinase activity. Blood 1960;15:212-227.
10. Gonyea L, Herdman R, Bridges RA. The coagulation abnormalities in systemic lupus erythematosus. Thromb Diath Haemorrh 1968;20:457-464.
11. Corrigan JJ, Patterson JH, May NE. Incoagulability of the blood in systemic lupus erythematosus. Am J Dis Child 1970;119:365-369.
12. Natelson EA, Cyprus GS, Hettig RA. Absent factor II in systemic lupus erythematosus. Arthritis Rheum 1976;19:79-82.
13. Lillquist KB, Dyerberg J, Krogh-Jensen M. The absence of factor II in a child with systemic lupus erythematosus. Acta Paediatr Scand 1978; 67:533-536.
14. Bajaj SP, Rapaport SI, Fierer DS, Herbst KD, Schwartz DB. A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome. Blood 1983;61:684-691.
15. Bernstein ML, Salusinsky-Sternbach M, Bellefleur M, Esseltine DW. Thrombotic and hemorrhagic complications in children with the lupus anticoagulant. Am J Dis Child 1984;138:1132-1135.
16. Bernini JC, Buchanan GR, Aschcraft J. Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant. J Pediatr 1993;123:937-939.
17. Jaeger U, Kapiotis S, Pabinger I, Puchhammer E, Kyrle PA, Lechner K. Transient lupus anticoagulant associated with hypoprothrombinemia and Factor XII deficiency following adenovirus. Ann Hematol 1993;67:95-99.
18. Humphries JE, Acker MN, Pinkston JE, Ruddy S. Transient lupus anticoagulant associated with prothrombin deficiency: Unusual cause of bleeding in a 5-year-old girl. Am J Pediatr Hematol Oncol 1994; 16:372-376.
19. Grau E, Real E, Pastor E, Ivorra J, Quecedo E. Prothrombin deficiency and hemorrhage associated with a lupus anticoagulant. Am J Hematol 1997;54:85.
20. Hudson N, Duffy CM, Rauch J, Paquin JD, Esdaile J. Catastrophic haemorrhage in a case of pediatric primary antiphospholipid syndrome and factor II deficiency. Lupus 1997;6:68-71.
21. Becton DL, Stine KC. Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: The hemorrhagic lupus anticoagulant syndrome. J Pediatr 1997;130:998-1000.
22. Schmugge M, Tolle S, Marbet GA, Laroche P, Meili EO. Gingival bleeding, epistaxis and haematoma three days after gastroenteritis: The haemorrhagic lupus anticoagulant syndrome. Eur J Pediatr 2001;160: 43-46.
23. Yacobovich JR, Uziel Y, Frieman Z, Radnay J, Wolach B. Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinemia syndrome. Rheumatology 2001;40:585-587.
24. Follea G, Coiffier B, Viale JP, Dechavanne M. Anti-prothrombinase and Factor II deficiency in a non SLE patient. Thromb Haemost 1981;46:670.
25. Shaulian E, Shoenfeld Y, Berliner S, Shaklai M, Pinkhas J. Surgery in patients with circulating lupus anticoagulant. Int Surg 1981;66:157-159.
26. Harrison RL, Alperin JB, Kumar D. Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use. Arch Pathol Lab Med 1987;11:719-722.
27. Simel DL, St. Clair EW, Adams J, Greenberg CS. Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome. Am J Med 1987;83:563-566.
28. Stomorken H, Gjemdal T, Bjoro K. Lupus anticoagulant: A unique case with lupus anticoagulant and habitual abortion together with antifactor II antibody and bleeding tendency. Gynecol Obstet Invest 1988;26:83-88.
29. Small P. Severe hemorrhage in a patient with circulating anticoagulant, acquired hypoprothrombinemia, and systemic lupus erythematosus. Arthritis Rheum 1988;31:1210-1211.
30. Hilt RJ, Bird AR, Sarembock BD. Acquired hypoprothrombinemia and lupus anticoagulant: Response to steroid therapy. Br J Rheumatol 1991;30:308-310.
31. Peacock NW, Levine SP. Case report: The lupus anticoagulanthypoprothrombinemia syndrome. Am J Med Sci 1994;307:346-349.
32. Pernod G, Arvieux J, Carpentier PH, Mossuz P, Bosson JL, Polack B. Successful treatment of lupus anticoagulant-hypoprothrombinemia syndrome using intravenous immunoglobulins. Thromb Haemost 1997;78:969-970.
33. Holm M, Andreasen R, Ingerslev J. Management of bleeding using recombinant Factor VIIa in a patient suffering from bleeding tendency due to a lupus anticoagulant-hypoprothrombinemia syndrome. Thromb Haemost 1999;82:1776-1778.
34. Ayoub O, Aljurf M, Al Nounou RE, Chaudhri NA. Systemic lupus erythematosus presenting with haemorraghic manifestation. Clin Lab Haematol 1999;21:413-416.
35. de Larrañaga G, Forastiero R, Carreras LO, Zala N, Guzmán L, Alonso B. Acquired hypoprothrombinemia related to high titres of antiproteinphospholipid antibodies. Thromb Haemost 1999;81:317-318.
36. Exner T, Triplett DA, Taberner D, Machin SJ. Guidelines for testing and revised criteria for lupus anticoagulants. Thromb Haemost 1991;65:320-325.
37. Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulant: An update. Thromb Haemost 1995;74:1185-1190.
38. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF. et al. The 1982 Revised Criteria for the Classification of Systemic Lupus Erythematosus. Arthritis Rheum 1982;25:1271-1277.
39. Triplett DA, Barna LK, Unger GA. A hexagonal (II) phase phospholipid neutralization assay for lupus anticoagulant identification. Thromb Haemost 1993;70:787-793.
40. Rauch J, Tannenbaum M, Tannenbaum H, Ramelson H, Cullis PR, Tilcock CPS, Hope MJ, Janoff AS. Human hybridoma lupus anticoagulants distinguish between lamellar and hexagonal phase lipid system. J Biol Chem 1986;26:9672-9677.
41. Rauch J, Tannenbaum M, Janoff AS. Distinguishing plasma lupus anticoagulants from anti-factor antibodies using hexagonal (II) phase phospholipids. Thromb Haemost 1989;62:892-896.
42. Rauch J, Tannenbaum M, Neville C, Fortin PR. Inhibition of lupus anticoagulant activity by hexagonal phase (II) phosphatidylethanolamine in the presence of prothrombin. Thromb Haemost 1998;80:936-941.
43. Fleck RA, Rapaport SI, Mohan Rao LV. Anti-prothrombin antibodies and the lupus anticoagulant. Blood 1988;72:512-519.