Decreased density of serotonin 5-HT2 A receptors in rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 65, Issue 6, 2006, Pages 816-819

  Kling, Anders ^a   Rantapaa Dahlqvist S ^a   Stenlund, H ^b   Mjorndal T ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 2A RECEPTOR;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MALE; PRIORITY JOURNAL; RADIOACTIVITY; RECEPTOR DENSITY; RHEUMATOID ARTHRITIS;

AGED; ARTHRITIS, RHEUMATOID; BINDING, COMPETITIVE; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT2A;

EID: 33744486333     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2005.042473     Document Type: Article

References (15)

1. Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K. Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 1998;12:319-38.
2. 3H]-LSD): intra- and interindividual variability. Neuropsychopharmacology 1997;16:285-93.
3. Khait VD, Huang YY, Zalsman G, Oquendo MA, Brent DA, Harkavy-Friedman JM, et al. Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Neuropsychopharmacology 2005;30:166-72.
4. Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, et al. The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis 1999;6:433-9.
5. Harbuz MS, Perveen-Gill Z, Lalies MD, Jessop DS, Lightman SL, Chowdrey HS. The role of endogenous serotonin in adjuvant-induced arthritis in the rat. Br J Rheumatol 1996;35:112-6.
6. Harbuz MS, Marti O, Lightman SL, Jessop DS. Alteration of central serotonin modifies onset and severity of adjuvant-induced arthritis in the rat. Br J Rheumatol 1998;37:1077-83.
7. Pierce P, Xie G-X, Peroutka SJ, et al. 5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2a receptors on sympathetic efferent terminals. J Pharmacol Exp Ther 1995;275:502-8.
8. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
9. Baecklund E, Ekbom A, Sparen P, Feltelius N, Klareskog L. Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study. BMJ 1998;317:180-1.
10. Pini LA, Sandrini M, Vitale G. The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Eur J Pharmacol 1996;308:31-40.
11. Sandrini M, Vitale G, Pini LA. Central antinociceptive activity of acetylsalicylic acid is modulated by brain serotonin receptor subtypes. Pharmacology 2002;65:193-7.
12. Dean B. The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice. J Neurochem 2003;85:1-13.
13. Abdolmaleky HM, Faraone SV, Glatt SJ, Tsuang MT. Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 2004;67:53-62.
14. Eaton WW, Hayward C, Ram R. Schizophrenia and rheumatoid arthritis: a review. Schizophr Res 1992;6:181-92.
15. Gorwood P, Pouchot J, Vinceneux P, Puechal X, Flipo RM, De Bandt M, et al. Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level. Schizopnr Res 2004;66:21-9.