Assessment of an anti-HIV-1 combination gene therapy strategy using the antisense RNA and multimeric hammerhead ribozymes

Frontiers in Bioscience

Volumn 11, Issue SUPPL. 3, 2006, Pages 2940-2948

  Ramezani, Ali ^a,b   Ma, Xue Zhong ^a   Ameli, Masoud ^a   Arora, Alka ^a   Joshi, Sadhna ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antisense RNA; Combination strategy; Gene therapy; Hammerhead ribozymes; HIV; MGIN; MoTiN; MoTN; Multimeric ribozymes; Oncoretroviral vector

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE;

EID: 33744482067     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2023     Document Type: Article

References (27)

1. Pomerantz, R.J. and D. Trono: Genetic therapies for HIV infections: promise for the future. AIDS 9, 985-993 (1995)
2. Lever A.M.: Gene therapy for HIV infection. British Med Bull 51, 149-166 (1995)
3. Lamothe B. & S. Joshi: Current developments and future prospects for HIV gene therapy using interfering RNA-based strategies. Front Biosci 5, 527-555 (2000)
4. Singwi S. & S. Joshi: Potential nuclease-based strategies for HIV gene therapy. Front Biosci 5, 556-579 (2000)
5. Strayer D.S., R. Akkina, B.A. Bunnell, B, Dropulic, V. Planelles, R.J. Pomerantz, J.J. Rossi & J.A. Zaia: Current status of gene therapy strategies to treat HIV/AIDS. Mol Ther 11, 823-842 (2005)
6. Chen C.J., A.C. Banerjee, G.G. Harmison, K. Haglund & M. Schubert: Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication-potential effectiveness against most presently sequenced HIV-1 isolates. Nucleic Acids Res 20, 4581-4589 (1992)
7. Ramezani A., S.F. Ding & S. Joshi: Inhibition of HIV-1 replication by retroviral vectors expressing mono- and multimeric hammerhead ribozymes. Gene Ther 4, 1-7 (1997)
8. Ramezani A., X.Z. Ma, R. Nazari & S. Joshi: Development and testing of retroviral vectors expressing multimeric hammerhead ribozymes against all major clades of HIV-1. Front Biosci 1, 29-36 (2002)
9. Cohli H., B. Fan, R.L. Joshi, A. Ramezani, X. Li & S. Joshi: Inhibition of HIV-1 multiplication in a human CD4+ lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and RRE element(s). Antisense Res Develop 4, 19-26 (1994)
10. Ding S.F., J. Noronha & S. Joshi: Co-packaging of sense and antisense RNAs: a novel strategy for blocking HIV-1 replication. Nucleic Acids Res 26, 3270-3278 (1998)
11. Veres G., S. Escaich, J. Baker, C. Barske, C. Kalfoglou, H. Ilves, H. Kaneshima & E. Bohnlein: Intracellular expression of RNA transcripts complementary to the HIV-1 gag gene inhibits viral replication in human CD4+ lymphocytes. J Virol 70, 8792-8800 (1996)
12. Magli M.C., J.E. Dick, D. Huszar, A. Bernstein & P.A. Phillips: Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Proc Natl Acad Sci 84, 789-793 (1987)
13. Joshi S., L. Davison, A. Van Brunschot & I. Van der Elst: A retroviral vector to allow constitutive and Tat-inducible gene expression for anti-HIV-1 gene therapy. Mol Biol Life Sci Adv 12, 185-189 (1993)
14. Weerasinghe M., S.E. Liem, S. Asad, S.E. Read & S. Joshi: Resistance to HIV-1 infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA specific ribozyme. J Virol 65, 5531-5534 (1991)
15. Ramezani A. & S. Joshi: Comparative analysis of five highly conserved sites within the HIV-1 RNA for their susceptibility to hammerhead ribozyme-mediated cleavage in vitro and in vivo. Antisense Nucleic Acid Drug Dev 6, 229-235 (1996)
16. Cheng L., C. Du, D. Murray, X. Tong, Y.A. Zhang, P.B. Chen & R.G. Hawley: A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells. Gene Ther 4, 1013-1022 (1997)
17. th World AIDS conference, 435-439 (1998)
18. Adachi A., H.E. Gendleman, S. Koenig, T. Folks, R. Willey, A. Rabson & M.A. Martin: Production of AIDS-associated retrovirus in human and non human cells transfected with an infectious molecular clone. J Virol 59, 284-291 (1986)
19. Melekhovets Y.F. & S. Joshi: Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro. Nucleic Acids Res 24, 1908-1912 (1996)
20. Pauwels R., E. DeClerq, J. Desmyter, J. Balzarini, P. Goubau, P. Herdewijn, H. Banderhaeghe & M. Van de Putte: Sensitive and rapid assay on MT4 cells for detection of antiviral compounds against the ADDS virus. J Virol Methods 16, 171-185 (1987)
21. Larder B.A., G. Darby & D.D. Richman: HIV with reduced sensitivity to Zidovudine isolates during prolonged therapy. Science 243, 1731-1734 (1989)
22. Liera S.E., A. Ramezani, X. Li & S. Joshi: The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance. Hum Gene Ther 4, 625-634 (1993)
23. Sambrook J., E.F. Fritsch & T. Maniatis: Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989)
24. Chomczynski P. & N. Sacchi: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159 (1987)
25. Singwi S., S. Ding, A. Ramezani & S. Joshi: Targeted RNases: a feasibility study for use in HIV gene therapy. Gene Ther 6, 913-921 (1999)
26. Vodicka M.A., W.C. Goh, L.I. Wu, M.E. Rogel, S.R. Bartz, V.L. Schweickart, C.J. Raport & M. Emerman: Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology 233, 193-198 (1997)
27. Veres G., U. Junker, J. Baker, C. Barske, C. Kalfoglou, H. I lves, S. Escaich, H. Kaneshima & E. Bohnlein: Comparative analyses of intracellularly expressed antisense RNAs as inhibitors of HIV-1 replication. J Virol 72, 1894-1901 (1998)