Fusion with an RNA binding domain to confer target RNA specificity to an RNase: Design and engineering of Tat-RNase h that specifically recognizes and cleaves HIV-1 RNA in vitro

Nucleic Acids Research

Volumn 24, Issue 10, 1996, Pages 1908-1912

  Melekhovets, Yuri F ^a   Joshi, Sadhna ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; RIBONUCLEASE; RNA DIRECTED DNA POLYMERASE; TRANSACTIVATOR PROTEIN; VIRUS RNA;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA BINDING; RNA CLEAVAGE; STRUCTURE ACTIVITY RELATION;

BASE SEQUENCE; BINDING SITES; DRUG DESIGN; GENE PRODUCTS, TAT; HIV-1; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; RIBONUCLEASE H, CALF THYMUS; RNA; RNA, VIRAL; SUBSTRATE SPECIFICITY; TRANS-ACTIVATION (GENETICS);

EID: 0029931402     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/24.10.1908     Document Type: Article

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