Nonmodulation and essential hypertension

Current Hypertension Reports

Volumn 8, Issue 2, 2006, Pages 127-131

  Hollenberg, Norman K ^a   Williams, Gordon H ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; ADDUCIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSINOGEN; ATRIAL NATRIURETIC FACTOR; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INULIN; NITRIC OXIDE; PROSTAGLANDIN; RENIN;

ALDOSTERONE RELEASE; ARTICLE; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; GENETIC ANALYSIS; GENETIC EPISTASIS; GENOTYPE PHENOTYPE CORRELATION; HUMAN; KALLIKREIN KININ SYSTEM; KIDNEY BLOOD FLOW; KIDNEY CIRCULATION; KIDNEY PERFUSION; MICROALBUMINURIA; NONHUMAN; PATHOPHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENIN RELEASE; SALT INTAKE; SALT LOADING; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM ABSORPTION; SODIUM RESTRICTION; TWIN CONCORDANCE;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANGIOTENSINOGEN; HUMANS; HYPERTENSION; KIDNEY; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RENAL CIRCULATION; RENIN; RENIN-ANGIOTENSIN SYSTEM; SODIUM;

EID: 33744471650     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-006-0008-9     Document Type: Article

References (35)

1. Hollenberg NK, Williams GH: Abnormal renal function, sodium-volume homeostasis and renin system behavior in normal-renin essential hypertension: the evolution of the nonmodulator concept. In Hypertension: Pathophysiology, Diagnosis, and Management, edn 2. Edited by Laragh JH, Brenner BM. New York: Raven Press; 1995:1837-1856.
2. Hollenberg NK, Merrill JP: Intrarenal perfusion in the young "essential" hypertensive: a subpopulation resistant to sodium restriction. Trans Assoc Am Physicians 1970, 83:93-101.
3. Williams GH, Rose LI, Dluhy RG, et al.: Abnormal responsiveness of the renin-aldosterone system to acute stimulation in patients with essential hypertension. Ann Intern Med 1970, 72:317-326.
4. Hollenberg NK, Chenitz WR, Adams DF, Williams GH: Reciprocal influence of salt intake on adrenal glomerulosa and renal vascular responses to angiotensin II in normal man. J Clin Invest 1974, 54:34-42.
5. Williams GH, Hollenberg NK: Accentuated vascular and endocrine responses to SQ 20881 in hypertension. N Engl J Med 1977, 297:184-188.
6. Hollenberg NK, Meggs LG, Williams GH, et al.: Sodium intake and renal responses to captopril in normal man and in essential hypertension. Kidney 1981, 20:240-245.
7. Redgrave JE, Rabinowe SL, Hollenberg NK, Williams GH: Correction of abnormal renal blood flow response to angiotensin II by converting-enzyme inhibition in essential hypertensives. J Clin Invest 1985, 75:1285-1290.
8. Fujita T, Henry WL, Bartter FC, et al.: Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med 1980, 69:334-344.
9. Rystedt LL, Williams GH, Hollenberg NK: The renal and endocrine response to saline infusion in essential hypertension. Hypertension 1986, 8:217-222.
10. Hollenberg NK, Moore T, Shoback D, et al.: Abnormal renal sodium handling in essential hypertension: relation to failure of renal and adrenal modulation of responses to Ang II. Am J Med 1986, 81:412-418.
11. Hurwitz S, Fisher NDL, Ferri C, et al.: Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type. J Hypertension 2003, 21:951-958.
12. Williams GH, Hollenberg NK, Moore TJ, et al.: Failure of renin suppression by angiotensin II in hypertension. Circ Res 1978, 4:46-52.
13. LeBoff MS, Dluhy RG, Hollenberg NK, et al.: Abnormal renin short feedback loop in essential hypertension is reversible with converting enzyme inhibition. J Clin Invest 1982, 70:335-341.
14. Seely EW, Moore TJ, Rogacz S, et al.: Angiotensin-mediated renin suppression is altered in non-modulating hypertension. Hypertension 1989, 13:31-37.
15. Williams GH, Tuck ML, Sullivan JM, et al.: Parallel adrenal and renal abnormalities in the young patient with essential hypertension. Am J Med 1982, 72:907-914.
16. Beretta-Piccoli C, Pusterla C, Stadler P, Weidmann P: Blunted aldosterone responsiveness to Ang II in normotensive subjects with familial predisposition to essential hypertension. J Hypertension 1988, 61:57-61.
17. Van Hooft IMS, Grobbee DE, Derkx FHM, et al.: Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents. N Engl J Med 1991, 324:1305-1311.
18. Uneda S, Fukishima S, Fujika Y, et al.: Renal hemodynamics and renin-angiotensin system in adolescents genetically predisposed to essential hypertension. J Hypertension 1984, 263:437-439.
19. Guidi E, Cozzi EMMG, Biella E: Sodium physiopathology and nonmodulating hypertension. In Cardiorenal Disease. Contrib Nephrol, vol 106. Edited by Timio M, Wizemann V. Basel, Switzerland: Karger Publishers; 1994:153-156.
20. Luparini RL, Ferri C, Santucci A, Balsano F: Atrial natriuretic peptide in non-modulating essential hypertension. Hypertension 1993, 21:803-809.
21. Ferri C, Bellini C, Coassin S, et al.: Abnormal atrial natriuretic peptide and renal responses to saline infusion in nonmodulating essential hypertensive patients. Circulation 1994, 90:2859-2869.
22. Bigazzi R, Bianchi S, Baldari D, et al.: Microalbuminuria in salt-sensitive patients: a marker for renal and cardiovascular risk factors. Hypertension 1994, 23:195-199.
23. Sanchez RA, Amos F, Giannone C, et al.: Parallel renal and extremity blood supply abnormalities in nonmodulation. Responses to ACE inhibition. Hypertension 2003, 41:919-924.
24. Sanchez RA, Ramos F, Giannone C, et al.: Increased microalbuminuria and forearm vascular abnormalities in non-modulating hypertensives and offspring of hypertensives. Similar kidney and peripheral response to ACEI. J Hum Hypertens Suppl 2002, 16:128-132.
25. Sanchez R, Gimenez MI, Ramos F, et al.: Non-modulating hypertension: evidence for the involvement of kallikrein/kinin activity associated with overactivity of the renin-angiotensin system. Successful blood pressure control during long-term Na+ restriction. J Hypertension 1996, 14:1287-1291.
26. Razin M, Borosh M, Weinstock M: Rabbits with a genetic impairment in baroreceptor reflex sensitivity show abnormal renal haemodynamics and proximal tubular sodium reabsorption in response to a saline infusion. J Hypertens 1993, 11:799-804.
27. Widgren BR, Herlitz H, Aurell M, et al.: Increased systemic and renal vascular sensitivity to angiotensin II in normotensive men with positive family histories of hypertension. Am J Hypertens 1992, 5:167-174.
28. Palmgren E, Widgren B, Aurell M, Herlitz H: Increased renal vascular sensitivity to angiotensin II in hypertension is due to decreased respose to prostaglandins. J Hypertens 2003, 21:969-976.
29. Schachinger H, Dieterle T, Martina B, et al.: Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition. J Hypertens 2004, 22:175-180.
30. Lifton RP, Hopkins PN, Williams RR, et al.: Evidence for heritability of non-modulating essential hypertension. Hypertension 1989, 13:884-889.
31. Williams GH, Dluhy RG, Lifton RP, et al.: Non-modulation as an intermediate phenotype in essential hypertension. Hypertension 1992, 20:788-796.
32. Hopkins PN, Lifton RP, Hollenberg NK, et al.: Blunted renal vascular response to angiotensin I is associated with a common variant of the angiotensinogen gene and obesity. J Hypertens 1996, 14:199-207.
33. Hopkins PN, Hunt SC, Jeunemaitre X, et al.: Angiotensin genotype effect on renal and adrenal responses to angiotensin II in essential hypertension. Circulation 2002, 105:1921-1927.
34. Kosachunhanun N, Hunt SC, Hopkins PN, et al.: Genetic determinants of nonmodulating hypertension. Hypertension 2003, 42:901-908.
35. Klingbeil AU, Jacobi J, Langenfeld MRW, et al.: Enhanced antinatriuresis in response to angiotensin II in essential hypertension. Am J Hypertension 2000, 13:986-993.