Central serotonergic and noradrenergic receptors in functional dyspepsia

World Journal of Gastroenterology

Volumn 12, Issue 17, 2006, Pages 2681-2687

  O'Mahony, S ^a   Dinan, T G ^a   Keeling, P W ^b   Chua, A S B ^c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c Ipoh Gastro Centre   (Malaysia)

Author keywords

Functional dyspepsia; Gastrointestinal disorders; Noradrenaline; Serotonin

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BUSPIRONE; CLONIDINE; DESIPRAMINE; GLYCERYL TRINITRATE; NORADRENALIN; PROKINETIC AGENT; PROTON PUMP INHIBITOR; SEROTONIN; SEROTONIN 1 AGONIST; SEROTONIN 1 RECEPTOR; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN RECEPTOR; STOMACH SECRETION INHIBITOR;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ARTICLE; BEHAVIOR THERAPY; BLOATING; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COGNITIVE THERAPY; DOSE RESPONSE; DRUG ABSORPTION; DRUG EFFICACY; DRUG MECHANISM; DYSPEPSIA; GASTROINTESTINAL MOTILITY; HUMAN; HYPNOSIS; NAUSEA; NOCICEPTION; NONHUMAN; NORADRENERGIC SYSTEM; PATHOGENESIS; PROTEIN FUNCTION; RISK FACTOR; SENSORY NERVE; SEROTONINERGIC SYSTEM;

EID: 33744461598     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i17.2681     Document Type: Article

References (61)

1. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JF, Tytgat GN. Functional gastroduodenal disorders. Gut 1999; 45 Suppl 2: 1137-1142
2. Jones MP. Evaluation and treatment of dyspepsia. Postgrad Med J 2003; 79: 25-29
3. Soo S, Moayyedi P, Deeks J, Delaney B, Lewis M, Forman D. Psychological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev 2005;: CD002301
4. Camilleri M. Nonulcer dyspepsia: a look into the future. Mayo Clin Proc 1996; 71: 614-622
5. Thumshirn M. Pathophysiology of functional dyspepsia. Gut 2002; 51 Suppl 1: i63-i66
6. Moayyedi P, Deeks J, Talley NJ, Delaney B, Forman D. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. Am J Gastroenterol 2003; 98: 2621-2626
7. Thumshirn M, Camilleri M, Choi MG, Zinsmeister AR. Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology 1999; 116: 573-585
8. Baker DE. Rationale for using serotonergic agents to treat irritable bowel syndrome. Am J Health Syst Pharm 2005; 62: 700-711; quiz 712-713
9. Gershon MD. Serotonin and its implication for the management of irritable bowel syndrome. Rev Gastroenterol Disord 2003; 3 Suppl. 2: S25-S34
10. Ringel Y. Brain research in functional gastrointestinal disorders. J Clin Gastroenterol 2002; 35: S23-S25
11. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ 3rd. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000; 75: 907-912
12. Talley NJ, Weaver AL, Zinsmeister AR. Impact of functional dyspepsia on quality of life. Dig Dis Sci 1995; 40: 584-589
13. Holtmann G, Liebregts T, Siffert W. Molecular basis of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18: 633-640
14. Alpers DH. Why should psychotherapy be a useful approach to management of patients with nonulcer dyspepsia? Gastroenterology 2000; 119: 869-871
15. Haug TT, Wilhelmsen I, Ursin H, Berstad A. What are the real problems for patients with functional dyspepsia? Scand J Gastroenterol 1995; 30: 97-100
16. O'Malley PG, Jackson JL, Kroenke K, Yoon K, Hornstein E, Dennis GJ. The value of screening for psychiatric disorders in rheumatology referrals. Arch Intern Med 1998; 158: 2357-2362
17. Camilleri M, Malagelada JR, Kao PC, Zinsmeister AR. Gastric and autonomic responses to stress in functional dyspepsia. Dig Dis Sci 1986; 31:1169-1177
18. Bennett EJ, Tennant CC, Piesse C, Badcock CA, Kellow JE. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut 1998; 43: 256-261
19. Talley NJ, Phillips SF. Non-ulcer dyspepsia: potential causes and pathophysiology. Ann Intern Med 1988; 108: 865-879
20. Bueno L, Fioramonti J, Delvaux M, Frexinos J. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology 1997; 112: 1714-1743
21. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994; 107: 271-293
22. Al-Chaer ED, Lawand NB, Westlund KN, Willis WD. Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: a new function for the dorsal colurnn pathway. J Neurophysiol 1996; 76:2661-2674
23. Al-Chaer ED, Feng Y, Willis WD. A role for the dorsal column in nociceptive visceral input into the thalamus of primates. J Neurophysiol 1998; 79: 3143-3150
24. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut 2001; 48: 125-131
25. Kim DY, Camilleri M. Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 2000; 95: 2698-2709
26. Nolte J. The Human Brain. 4th ed. Arizona. Mosby, 1999 :272-275
27. Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984; 7:309-338
28. Sawynok J, Reid A. Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception. Behav Brain Res 1996; 73: 63-68
29. Alhaider AA, Hamon M, Wilcox GL. Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors. Eur J Pharmacol 1993; 249: 151-160
30. Archer T, Jonsson G, Minor BG, Post C. Noradrenergic-serotonergic interactions and nociception in the rat. Eur J Pharmacol 1986; 120: 295-307
31. Feuerstein HL, Herrting G. Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS. Naunyn-Schmeideberg's Arch Pharmacology 1986; 333: 191-197
32. Sagen J, Proudfit HK. Effect of intrathecally administered noradrenergic antagonists on nociception in the rat. Brain Res 1984; 310: 295-301
33. McIntyre AS, Thompson DG. Review article: adrenergic control of motor and secretory function in the gastrointestinal tract. Aliment Pharmacol Ther 1992; 6: 125-142
34. Bharucha AE, Novak V, Camilleri M, Zinsmeister AR, Hanson RB, Low PA. Alpha 2-adrenergic modulation of colonic tone during hyperventilation. Am J Physiol 1997; 273: G1135-G1140
35. Nagata M, Osumi Y. Central alpha 2-adrenoceptor-mediated inhibition of gastric motility in rats. Jpn J Pharmacol 1993; 62: 329-330
36. Jiang Q, Sheldon RJ, Porreca F. Sites of clonidine action to inhibit gut propulsion in mice: demonstration of a central component. Gastroenterology 1988; 95: 1265-1271
37. Tack J, Sarnelli G. Serotonergic modulation of visceral sensation: upper gastrointestinal tract. Gut 2002; 51 Suppl 1: i77-i80
38. Thumshirn K Camilleri M, Saslow SB, Williams DE, Burton DD, Hanson RB. Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. Gut 1999; 44: 55-64
39. Lemann M, Dederding JP, Flourie B, Franchisseur C, Rambaud JC, Jian R. Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia. The irritable stomach syndrome. Dig Dis Sci 1991; 36: 1249-1254
40. Mayer EM. The neurobiology of stress and gastrointestinal disease. Gut 2000; 47: 861-869
41. Azpiroz F. Hypersensitivity in functional gastrointestinal disorders. Gut 2002; 51 Suppl. 1: i25-i28
42. Iovino P, Azpiroz F, Domingo E, Malagelada JR. The sympathetic nervous system modulates perception and reflex responses to gut distention in humans. Gastroenterology 1995; 108: 680-686
43. Delvaux MM. Stress and visceral perception. Can J Gastroenterol 1999; 13 Suppl A: 32A-36A
44. Wei F, Dubner R, Ren K. Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. Pain 1999; 80: 127-141
45. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM. Neurohormonal factors in functional dyspepsia: insights on pathophysiological mechanisms. Gastroenterology 1991; 100: 1311-1318
46. Troncon LE, Bennett RJ, Ahluwalia NK, Thompson DG. Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients. Gut 1994; 35: 327-332
47. Coffin B, Azpiroz F, Guarner F, Malagelada JR. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology 1994; 107:1345-1351
48. Tougas G. The autonomic nervous system in functional bowel disorders. Gut 2000; 47 Suppl 4: iv78-iv80, discussion iv87
49. Flugge G. Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress. Neuroscience 1996; 75: 187-196
50. Bremmer JD, Innis RB, Ng CY, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1997; 54: 246-254
51. Halder SL, Talley NJ. Treatment of functional dyspepsia. Curr Treat Options Gastroenterol 2005; 8:325-336
52. Whitehead WE. Psychosocial aspects of functional gastrointestinal disorders. Gastroenterol Clin North Am 1996; 25: 21-34
53. Haug TT, Wilhelmsen I, Svebak S, Berstad A, Ursin H. Psychotherapy in functional dyspepsia. J Psychosom Res 1994; 38: 735-744
54. Hamilton J, Guthrie E, Creed F, Thompson D, Tomenson B, Bennett R, Moriarty K, Stephens W, Liston R, A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology 2000; 119: 661-669
55. Dinan TG, Yatham LN, Barry S, Chua A, Keeling PW. Serotonin supersensitivity: the pathophysiologic basis of nonulcer dyspepsia? A preliminary report of buspirone/prolactin responses. Scand J Gastroenterol 1990; 25: 541-544
56. Neuhauser H, Laakmann G, Knossalla A. Neuroendocrine effects of buspirone. 16th CINP congress. Psychopharmacology 1988; 96 Suppl 1: 393
57. Frissora CL, Koch KL. Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Curr Gastroenterol Rep 2005; 7: 264-271
58. Dinan TG, Barry S, Ahkion S, Chua A, Keeling PW. Assessment of central noradrenergic functioning in irritable bowel syndrome using a neuroendocrine challenge test. J Psychosom Res 1990; 34: 575-580
59. Laakmann G, Schumacher G, Benkert O. Stimulation of growth hormone secretion by desimipramin and chlorimipramin in man. J Clin Endocrinol Metab 1977, 44: 1010-1013
60. Salvatore R. The standards of human growth hormone assays. In Evaluation of Growth Hormone Secretion (Edited by Laron and Butenandt). Bascl: Karger, 1983
61. Dinan TG, Barry S. Responses of growth hormone to desipramine in endogenous and non-endogenous depression. Br J Psychiatry 1990; 156: 680-684