The effect of matrix tension-compression nonlinearity and fixed negative charges on chondrocyte responses in cartilage

MCB Molecular and Cellular Biomechanics

Volumn 2, Issue 4, 2005, Pages 191-204

  Likhitpanichkul, Morakot ^a   Guo, X Edward ^a   Mow, Van C ^a  

^a Columbia University ^*  (United States)

Author keywords

Articular cartilage; Cell Matix interaction; Fixed charge density; Multi scale finite element model; Tension Compression nonlinearity; Triphasic theory; Unconfined compression

Indexed keywords

BIOMEDICAL ENGINEERING; CARTILAGE; CELLS; COMPUTER SIMULATION; FINITE ELEMENT METHOD; MATHEMATICAL MODELS; POISSON RATIO;

ARTICULAR CARTILAGE; CELL-MATRIX INTERACTION; MECHANO-ELECTROCHEMICAL INTERACTIONS; TENSION-COMPRESSION NONLINEARITY;

BIOMECHANICS;

PROTEOGLYCAN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CARTILAGE; CARTILAGE CELL; CHEMISTRY; COMPRESSIVE STRENGTH; ELECTRICITY; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; METABOLISM; NONLINEAR SYSTEM; TENSILE STRENGTH; WEIGHT BEARING;

ANIMALS; CARTILAGE; CHONDROCYTES; COMPRESSIVE STRENGTH; ELECTROSTATICS; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PROTEOGLYCANS; TENSILE STRENGTH; WEIGHT-BEARING;

EID: 33744459975     PISSN: 15565297     EISSN: 15565300     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Alexopoulos, L. G.; Haider, M. A.; Vail, T. P.; Guilak, F. (2003): Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng, vol. 125, pp. 323-33.
2. Alexopoulos, L. G.; Williams, G. M.; Upton, M. L.; Setton, L. A.; Guilak, F. (2005): Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech, vol. 38, pp. 509-17.
3. Armstrong, C. G.; Lai, W. M.; Mow, V. C. (1984): An analysis of the unconfined compression of articular cartilage. J Biomech Eng, vol. 106, pp. 165-73.
4. Bachrach, N. M.; Valhmu, W. B.; Stazzone, E.; Ratcliffe, A.; Lai, W. M.; Mow, V. C. (1995): Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment. J Biomech, vol. 28, pp. 1561-9.
5. Buschmann, M. D.; Gluzband, Y. A.; Grodzinsky, A. J.; Hunziker, E. B. (1995): Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci, vol. 108 (Pt 4), pp. 1497-508.
6. Chao, P. H.; Roy, R.; Mauck, R. L.; Liu, W.; Valhmu, W. B.; Hung, C. T. (2000): Chondrocyte translocation response to direct current electric fields. J Biomech Eng, vol. 122, pp. 261-7.
7. Curnier, A.; He, Q.-C.; Zysset, P. (1995): Conewise linear elastic materials. J Elast, vol. 37, pp. 1-38.
8. Goodier, J. (1937): Concentration of stress around spherical and cylindrical inclusions and flaws. J Appl Mech, vol. 55, pp. 39-44.
9. Gu, W. Y.; Yao, H. (2003): Effects of hydration and fixed charge density on fluid transport in charged hydrated soft tissues. Ann Biomed Eng, vol. 31, pp. 1162-70.
10. Gu, W. Y.; Yao, H.; Huang, C. Y.; Cheung, H. S. (2003): New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression. J Biomech, vol. 36, pp. 593-8.
11. Guilak, F.; Sah, R. L.; Setton, L. A., (1997), Physical regulation of cartilage metabolism, In: V. C. Mow, and W. C. Hayes (ed). Basic orthopaedic biomechanics, Philadelphia, pp. 179-207.
12. Guilak, F.; Mow, V. C. (2000): The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage. J Biomech, vol. 33, pp. 1663-73.
13. Heinegard, D.; Bayliss, M.; Lorenzo, P., (2003), Pathogenesis of structural changes in the osteoarthritic joint, In: K. D. Brandt, M. Doherty, and L. S. Lohmander (ed). Osteoarthritis, pp. 73-82.
14. Huang, C. Y.; Soltz, M. A.; Kopacz, M.; Mow, V. C.; Ateshian, G. A. (2003): Experimental verification of the roles of intrinsic matrix viscoelasticity and tension-compression nonlinearity in the biphasic response of cartilage. J Biomech Eng, vol. 125, pp. 84-93.
15. Huang, C. Y.; Stankiewicz, A.; Ateshian, G. A.; Mow, V. C. (2005): Anisotropy, inhomogeneity, and tension-compression nonlinearity of human glenohumeral cartilage in finite deformation. J Biomech, vol. 38, pp. 799-809.
16. Hung, C. T.; LeRoux, M. A.; Palmer, G. D.; Chao, P. H.; Lo, S.; Valhmu, W. B. (2003): Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture. Biorheology, vol. 40, pp. 61-72.
17. Jin, M.; Frank, E. H.; Quinn, T. M.; Hunziker, E. B.; Grodzinsky, A. J. (2001): Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants. Arch Biochem Biophys, vol. 395, pp. 41-8.
18. Lai, W. M.; Hou, J. S.; Mow, V. C. (1991): A triphasic theory for the swelling and deformation behaviors of articular cartilage. J Biomech Eng, vol. 113, pp. 245-58.
19. Lai, W. M.; Sun, D. D.; Ateshian, G. A.; Guo, X. E.; Mow, V. C. (2002): Electrical signals for chondrocytes in cartilage. Biorheology, vol. 39, pp. 39-45.
20. Lammi, M. J.; Inkinen, R.; Parkkinen, J. J.; Hakkinen, T.; Jortikka, M.; Nelimarkka, L. O.; Jarvelainen, H. T.; Tammi, M. I. (1994): Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure. Biochem J, vol. 304 ( Pt 3), pp. 723-30.
21. Leipzig, N. D.; Athanasiou, K. A. (2005): Unconfined creep compression of chondrocytes. J Biomech, vol. 38, pp. 77-85.
22. Maroudas, A., (1979), Physicochemical properties of articular cartilage., In: M. A. R. Freeman ed., Adult Articular Cartilage, Kent, UK, pp. 215-290.
23. Mauck, R. L.; Soltz, M. A.; Wang, C. C.; Wong, D. D.; Chao, P. H.; Valhmu, W. B.; Hung, C. T.; Ateshian, G. A. (2000): Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng, vol. 122, pp. 252-60.
24. Mobasheri, A.; Carter, S. D.; Martin-Vasallo, P.; Shakibaei, M. (2002): Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes. Cell Biol Int, vol. 26, pp. 1-18.
25. Mow, V. C.; Kuei, S. C.; Lai, W. M.; Armstrong, C. G. (1980): Biphasic creep and stress relaxation of articular cartilage in compression: Theory and experiments. J Biomech Eng, vol. 102, pp. 73-84.
26. Mow, V. C.; Wang, C. C.; Hung, C. T. (1999): The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage. Osteoarthritis Cartilage, vol. 7, pp. 41-58.
27. Mow, V. C.; Gu, W. Y.; Chen, F. H., (2005), Structure and function of articular cartilage and meniscus, In: V. C. Mow, and R. Huiskes (ed). Basic orthopaedic biomechanics and mechano-biology, Philadelphia, pp. 181-258.
28. Palmer, G. D.; Chao, P. H.; Raia, R; Mauck, R. L.; Valhmu, W. B.; Hung, C. T. (2001): Time-dependent aggrecan gene expression of articular chondrocytes in response to hyperosmotic loading. Osteoarthritis Cartilage, vol. 9, pp. 761-70.
29. Poole, C. A.; Glant, T. T.; Schofield, J. R. (1991): Chondrons from articular cartilage. (IV). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons. J Histochem Cytochem, vol. 39, pp. 1175-87.
30. Quinn, T. M.; Grodzinsky, A. J.; Buschmann, M. D.; Kim, Y. J.; Hunziker, E. B. (1998): Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants. J Cell Sci, vol. 111 (Pt 5), pp. 573-83.
31. Ratcliffe, A.; Beauvais, P. J.; Saed-Nejad, F. (1994): Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse. J Orthop Res, vol. 12, pp. 464-73.
32. Sandy, J. D.; Adams, M. E.; Billingham, M. E.; Plaas, A.; Muir, H. (1984): In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis. Arthritis Rheum, vol. 27, pp. 388-97.
33. Soltz, M. A.; Ateshian, G. A. (2000): A Conewise Linear Elasticity mixture model for the analysis of tension-compression nonlinearity in articular cartilage. J Biomech Eng, vol. 122, pp. 576-86.
34. Sun, D. D.; Guo, X. E.; Likhitpanichkul, M.; Lai, W. M.; Mow, V. C. (2004): The influence of the fixed negative charges on mechanical and electrical behaviors of articular cartilage under unconfined compression. J Biomech Eng, vol. 126, pp. 6-16.
35. Sun, D. N.; Gu, W. Y.; Guo, X. E.; Lai, W. M.; Mow, V. C. (1999): A mixed finite element formulation of triphasic mechano-electrochemical theory for charged, hydrated biological soft tissues. Int J Num Meth Engng, vol. 45, pp. 1375-1402.
36. Szafranski, J. D.; Grodzinsky, A. J.; Burger, E.; Gaschen, V.; Hung, H. H.; Hunziker, E. B. (2004): Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthritis Cartilage, vol. 12, pp. 937-46.
37. Waldman, S. D.; Spiteri, C. G.; Grynpas, M. D.; Pilliar, R. M.; Kandel, R. A. (2003): Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro. J Orthop Res, vol. 21, pp. 590-6.
38. Wan, L. Q.; Miller, C.; Guo, X. E.; Mow, V. C. (2004): Fixed electrical charges and mobile ions affect the measurable mechano-electrochemical properties of charged-hydrated biological tissues: The articular cartilage paradigm. Mechanics & Chemistry of Biosystems, vol. 1, pp. 81-99.
39. Wang, C. C.; Guo, X. E.; Sun, D.; Mow, V. C.; Ateshian, G. A.; Hung, C. T. (2002): The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approach. Biorheology, vol. 39, pp. 11-25.
40. Wang, C. C.; Chahine, N. O.; Hung, C. T.; Ateshian, G. A. (2003): Optical determination of anisotropic material properties of bovine articular cartilage in compression. J Biomech, vol. 36, pp. 339-53.
41. Wong, M.; Wuethrich, P.; Buschmann, M. D.; Eggli, P.; Hunziker, E. (1997): Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage. J Orthop Res, vol. 15, pp. 189-96.
42. Wu, J. Z.; Herzog, W. (2000): Finite element simulation of location- and time-dependent mechanical behavior of chondrocytes in unconfined compression tests. Ann Biomed Eng, vol. 28, pp. 318-30.
43. Wu, Q. Q.; Chen, Q. (2000): Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp Cell Res, vol. 256, pp. 383-91.