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A possible new bridge between innate and adaptive immunity: Are the anti-mitochondrial citrate synthase autoantibodies components of the natural antibody network?
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Lee J, Cho YJ, Lipsky PE: The V(lambda)-J(lambda) repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire. Arthritis Rheum 2004, 50:2604-2614. This paper supports the hypothesis that pathologic autoantibodies might derive from an innate immune response that was originally in the interests of the host.
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