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Volumn 13, Issue 1, 2006, Pages 49-55

Oxyntomodulin

Author keywords

Exendin 4; Food intake; Glucagon like peptide 1 (GLP 1); Oxyntomodulin

Indexed keywords

EXENDIN 4; GASTROINTESTINAL HORMONE; GLICENTIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; OXYNTOMODULIN;

EID: 33646924270     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.med.0000200526.08653.bb     Document Type: Review
Times cited : (5)

References (48)
  • 2
    • 14844334627 scopus 로고    scopus 로고
    • Appetite control
    • Wynne K, Stanley S, McGowan B, et al. Appetite control. J Endocrinol 2005; 184:291-318. Comprehensive review discussing current understanding of the mechanisms regulating food intake and body weight, with particular focus on the gut hormones.
    • (2005) J Endocrinol , vol.184 , pp. 291-318
    • Wynne, K.1    Stanley, S.2    McGowan, B.3
  • 3
    • 0020461555 scopus 로고
    • Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptide
    • Bataille D, Coudray AM, Carlqvist M, et al. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptide. FEBS Lett 1982; 146:73-78.
    • (1982) FEBS Lett , vol.146 , pp. 73-78
    • Bataille, D.1    Coudray, A.M.2    Carlqvist, M.3
  • 4
    • 0019527355 scopus 로고
    • 'Enteroglucagon': A specific effect on gastric glands isolated from the rat fundus. Evidence for an 'oxyntomodulin' action
    • Bataille D, Gespach C, Coudray AM, et al. 'Enteroglucagon': a specific effect on gastric glands isolated from the rat fundus. Evidence for an 'oxyntomodulin' action. Biosci Rep 1981; 1:151-155.
    • (1981) Biosci Rep , vol.1 , pp. 151-155
    • Bataille, D.1    Gespach, C.2    Coudray, A.M.3
  • 5
    • 0019983555 scopus 로고
    • Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): A potent inhibitor of pentagastrin-stimulated acid secretion in rats
    • Dubrasquet M, Bataille D, Gespach C. Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): a potent inhibitor of pentagastrin-stimulated acid secretion in rats. Biosci Rep 1982; 2:391-395.
    • (1982) Biosci Rep , vol.2 , pp. 391-395
    • Dubrasquet, M.1    Bataille, D.2    Gespach, C.3
  • 6
    • 0021259313 scopus 로고
    • A pure enteroglucagon, oxyntomodulin (glucagon 37), stimulates insulin release in perfused rat pancreas
    • Jarrousse C, Bataille D, Jeanrenaud B. A pure enteroglucagon, oxyntomodulin (glucagon 37), stimulates insulin release in perfused rat pancreas. Endocrinology 1984; 115:102-105.
    • (1984) Endocrinology , vol.115 , pp. 102-105
    • Jarrousse, C.1    Bataille, D.2    Jeanrenaud, B.3
  • 7
    • 0022355087 scopus 로고
    • Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion
    • Jarrousse C, Audousset-Puech MP, Dubrasquet M, et al. Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion. FEBS Lett 1985; 188:81-84.
    • (1985) FEBS Lett , vol.188 , pp. 81-84
    • Jarrousse, C.1    Audousset-Puech, M.P.2    Dubrasquet, M.3
  • 8
    • 0023714388 scopus 로고
    • Oxyntomodulin: A potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man
    • Schjoldager BT, Baldissera FG, Mortensen PE, et al. Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. Eur J Clin Invest 1988; 18:499-503.
    • (1988) Eur J Clin Invest , vol.18 , pp. 499-503
    • Schjoldager, B.T.1    Baldissera, F.G.2    Mortensen, P.E.3
  • 9
    • 0024442006 scopus 로고
    • Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions
    • Schjoldager B, Mortensen PE, Myhre J, et al. Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions. Dig Dis Sci 1989; 34:1411-1419.
    • (1989) Dig Dis Sci , vol.34 , pp. 1411-1419
    • Schjoldager, B.1    Mortensen, P.E.2    Myhre, J.3
  • 10
    • 0034807498 scopus 로고    scopus 로고
    • Oxyntomodulin inhibits food intake in the rat
    • Dakin CL, Gunn I, Small CJ, et al. Oxyntomodulin inhibits food intake in the rat. Endocrinology 2001; 142:4244-4250.
    • (2001) Endocrinology , vol.142 , pp. 4244-4250
    • Dakin, C.L.1    Gunn, I.2    Small, C.J.3
  • 11
    • 0036889316 scopus 로고    scopus 로고
    • Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats
    • Dakin CL, Small CJ, Park AJ, et al. Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats. Am J Physiol Endocrinol Metab 2002; 283:E1173-E1177.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Dakin, C.L.1    Small, C.J.2    Park, A.J.3
  • 12
    • 2542460293 scopus 로고    scopus 로고
    • Peripheral oxyntomodulin reduces food intake and body weight gain in rats
    • Dakin CL, Small CJ, Batterham RL, et al. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 2004; 145:2687-2695.
    • (2004) Endocrinology , vol.145 , pp. 2687-2695
    • Dakin, C.L.1    Small, C.J.2    Batterham, R.L.3
  • 13
    • 0242288734 scopus 로고    scopus 로고
    • Oxyntomodulin suppresses appetite and reduces food intake in humans
    • Cohen MA, Ellis SM, Le Roux CW, et al. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 2003; 88:4696-4701.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4696-4701
    • Cohen, M.A.1    Ellis, S.M.2    Le Roux, C.W.3
  • 14
    • 23644443678 scopus 로고    scopus 로고
    • Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial
    • Wynne K, Park AJ, Small CJ, et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 2005; 54:2390-2395. Important recent randomized controlled trial of subcutanous, preprandial administration of oxyntomodulin three times daily showing a significant weight loss in treated subjects over 4 weeks. There were no significant effects on blood glucose (unlike with GLP-1 and exendin 4) and the treatment was well tolerated.
    • (2005) Diabetes , vol.54 , pp. 2390-2395
    • Wynne, K.1    Park, A.J.2    Small, C.J.3
  • 15
    • 0024236086 scopus 로고
    • Oxyntomodulin and glicentin: Brain-gut peptides in the rat
    • Blache P, Kervran A, Bataille D. Oxyntomodulin and glicentin: brain-gut peptides in the rat. Endocrinology 1988; 123:2782-2787.
    • (1988) Endocrinology , vol.123 , pp. 2782-2787
    • Blache, P.1    Kervran, A.2    Bataille, D.3
  • 16
    • 0030901415 scopus 로고    scopus 로고
    • Enteroglucagon
    • Holst JJ, Enteroglucagon. Annu Rev Physiol 1997; 59:257-271.
    • (1997) Annu Rev Physiol , vol.59 , pp. 257-271
    • Holst, J.J.1
  • 17
    • 0020509994 scopus 로고
    • Molecular forms of human enteroglucagon in tissue and plasma: Plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract
    • Ghatei MA, Uttenthal LO, Christofides ND, et al. Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. J Clin Endocrinol Metab 1983; 57:488-495.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 488-495
    • Ghatei, M.A.1    Uttenthal, L.O.2    Christofides, N.D.3
  • 18
    • 0026718211 scopus 로고
    • Oxyntomodulin-like immunoreactivity: Diurnal profile of a new potential enterogastrone
    • Le Quellec A, Kervran A, Blache P, et al. Oxyntomodulin-like immunoreactivity: diurnal profile of a new potential enterogastrone. J Clin Endocrinol Metab 1992; 74:1405-1409.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1405-1409
    • Le Quellec, A.1    Kervran, A.2    Blache, P.3
  • 19
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993; 214:829-835.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 20
    • 0037928769 scopus 로고    scopus 로고
    • The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: In vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)
    • Zhu L, Tamvakopoulos C, Xie D, et al. The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38). J Biol Chem 2003; 278:22418-22423.
    • (2003) J Biol Chem , vol.278 , pp. 22418-22423
    • Zhu, L.1    Tamvakopoulos, C.2    Xie, D.3
  • 21
    • 0018602912 scopus 로고
    • Gut hormones in tropical malabsorption
    • Besterman HS, Cook GC, Sarson DL, et al. Gut hormones in tropical malabsorption. Br Med J 1979; 2:1252-1255.
    • (1979) Br Med J , vol.2 , pp. 1252-1255
    • Besterman, H.S.1    Cook, G.C.2    Sarson, D.L.3
  • 22
    • 0018358387 scopus 로고
    • Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio
    • Holst JJ, Sorensen TI, Andersen AN, et al. Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio. Scand J Gastroenterol 1979; 14:205-207.
    • (1979) Scand J Gastroenterol , vol.14 , pp. 205-207
    • Holst, J.J.1    Sorensen, T.I.2    Andersen, A.N.3
  • 23
    • 0019415970 scopus 로고
    • Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity
    • Sarson DL, Scopinaro N, Bloom SR. Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity. Int J Obes 1981; 5:471-480.
    • (1981) Int J Obes , vol.5 , pp. 471-480
    • Sarson, D.L.1    Scopinaro, N.2    Bloom, S.R.3
  • 24
    • 1642271221 scopus 로고    scopus 로고
    • Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects
    • Naslund E, King N, Mansten S, et al. Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects. Br J Nutr 2004; 91:439-446.
    • (2004) Br J Nutr , vol.91 , pp. 439-446
    • Naslund, E.1    King, N.2    Mansten, S.3
  • 25
    • 20544476444 scopus 로고    scopus 로고
    • Exenatide improves glycemic control and reduces body weight in subjects with type 2 diabetes: A dose-ranging study
    • Poon T, Nelson P, Shen L, et al. Exenatide improves glycemic control and reduces body weight in subjects with type 2 diabetes: a dose-ranging study. Diabetes Technol Ther 2005; 7:467-477. Short randomized controlled trial of exendin-4 as a potential treatment for type 2 diabetes, demonstrating its ability to reduce blood sugar. It also led to a significant reduction in body weight which was dose-dependent. Nausea was, however, a troublesome side-effect.
    • (2005) Diabetes Technol Ther , vol.7 , pp. 467-477
    • Poon, T.1    Nelson, P.2    Shen, L.3
  • 26
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005; 28:1092-1100. Prolonged randomized controlled trial of exendin-4 as a potential treatment for type 2 diabetes, demonstrating its ability to reduce blood sugar. Again there was a significant reduction in body weight which was dose-dependent.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3
  • 27
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang Q, Brown TJ, et al. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004; 127:546-558. An important paper examining the effects of OXM and GLP-1 in mice. The absence of effects of OXM in GLP-1 knockout mice suggests a mode of action via the GLP-1 receptor, but the two peptides had differential effects, suggesting possible downstream modulation of activity.
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3
  • 28
    • 0027315649 scopus 로고
    • Inhibition of gastric acid secretion by oxyntomodulin and its 19-37 fragment in the conscious rat
    • Jarrousse C, Carles-Bonnet C, Niel H, et al. Inhibition of gastric acid secretion by oxyntomodulin and its 19-37 fragment in the conscious rat. Am J Physiol 1993; 264:G816-G823.
    • (1993) Am J Physiol , vol.264
    • Jarrousse, C.1    Carles-Bonnet, C.2    Niel, H.3
  • 29
    • 0029895001 scopus 로고    scopus 로고
    • H-Lys-Arg-Asn-Lys-Asn-Asn-OH is the minimal active structure of oxyntomodulin
    • Carles-Bonnet C, Martinez J, Jarrousse C, et al. H-Lys-Arg-Asn-Lys-Asn- Asn-OH is the minimal active structure of oxyntomodulin. Peptides 1996; 17:557-561.
    • (1996) Peptides , vol.17 , pp. 557-561
    • Carles-Bonnet, C.1    Martinez, J.2    Jarrousse, C.3
  • 30
    • 0022511986 scopus 로고
    • Oxyntomodulin and its C-terminal octapeptide inhibit liquid meal-stimulated acid secretion
    • Jarrousse C, Niel H, Audousset-Puech MP, et al. Oxyntomodulin and its C-terminal octapeptide inhibit liquid meal-stimulated acid secretion. Peptides 1986; 7 (Suppl 1):253-256.
    • (1986) Peptides , vol.7 , Issue.1 SUPPL. , pp. 253-256
    • Jarrousse, C.1    Niel, H.2    Audousset-Puech, M.P.3
  • 31
    • 17444450664 scopus 로고    scopus 로고
    • Oxyntomodulin inhibits pancreatic secretion through the nervous system in rats
    • Anini Y, Jarrousse C, Chariot J, et al. Oxyntomodulin inhibits pancreatic secretion through the nervous system in rats. Pancreas 2000; 20:348-360.
    • (2000) Pancreas , vol.20 , pp. 348-360
    • Anini, Y.1    Jarrousse, C.2    Chariot, J.3
  • 32
    • 0023778665 scopus 로고
    • The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat
    • Gehl J, Jeppesen JL, Poulsen SS, et al. The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat. Digestion 1988; 40:144-151.
    • (1988) Digestion , vol.40 , pp. 144-151
    • Gehl, J.1    Jeppesen, J.L.2    Poulsen, S.S.3
  • 33
    • 0029829540 scopus 로고    scopus 로고
    • Oxyntomodulin: A cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2
    • Schepp W, Dehne K, Riedel T, et al. Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2. Digestion 1996; 57:398-405.
    • (1996) Digestion , vol.57 , pp. 398-405
    • Schepp, W.1    Dehne, K.2    Riedel, T.3
  • 34
    • 0026589005 scopus 로고
    • Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3)
    • Gros L, Demirpence E, Jarrousse C, et al. Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3). Endocrinology 1992; 130:1263-1270.
    • (1992) Endocrinology , vol.130 , pp. 1263-1270
    • Gros, L.1    Demirpence, E.2    Jarrousse, C.3
  • 35
    • 0025990908 scopus 로고
    • Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells
    • Tani T, Le Quellec A, Jarrousse C, et al. Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells. Biochim Biophys Acta 1991; 1095:249-254.
    • (1991) Biochim Biophys Acta , vol.1095 , pp. 249-254
    • Tani, T.1    Le Quellec, A.2    Jarrousse, C.3
  • 36
    • 0022497063 scopus 로고
    • Somatostatin enhances the inhibitory effect of oxyntomodulin and its C-terminal octapeptide on acid secretion
    • Dubrasquet JM, Audousset-Puech MP, Martinez J, et al. Somatostatin enhances the inhibitory effect of oxyntomodulin and its C-terminal octapeptide on acid secretion. Peptides 1986; 7 (Suppl 1):257-259.
    • (1986) Peptides , vol.7 , Issue.1 SUPPL. , pp. 257-259
    • Dubrasquet, J.M.1    Audousset-Puech, M.P.2    Martinez, J.3
  • 37
    • 0031822168 scopus 로고    scopus 로고
    • Oxyntomodulin reduces hydromineral transport through rat small intestine
    • Beauclair F, Eto B, Pansu D, et al. Oxyntomodulin reduces hydromineral transport through rat small intestine. Dig Dis Sci 1998; 43:1814-1823.
    • (1998) Dig Dis Sci , vol.43 , pp. 1814-1823
    • Beauclair, F.1    Eto, B.2    Pansu, D.3
  • 38
    • 0023442944 scopus 로고
    • The effect of oxyntomodulin (glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat
    • Biedzinski TM, Bataille D, Devaux MA, et al. The effect of oxyntomodulin (glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat. Peptides 1987; 8:967-972.
    • (1987) Peptides , vol.8 , pp. 967-972
    • Biedzinski, T.M.1    Bataille, D.2    Devaux, M.A.3
  • 39
    • 0031407438 scopus 로고    scopus 로고
    • Effect of glicentin, oxyntomodulin and related peptides on isolated gastric smooth muscle cells
    • Rodier G, Magous R, Mochizuki T, et al. Effect of glicentin, oxyntomodulin and related peptides on isolated gastric smooth muscle cells. Pflugers Arch 1997; 434:729-734.
    • (1997) Pflugers Arch , vol.434 , pp. 729-734
    • Rodier, G.1    Magous, R.2    Mochizuki, T.3
  • 40
    • 0032447417 scopus 로고    scopus 로고
    • A target cell to oxyntomodulin and glicentin: The antral smooth muscle cell
    • Rodier G, Magous R, Mochizuki T, et al. A target cell to oxyntomodulin and glicentin: the antral smooth muscle cell. Ann N Y Acad Sci 1998; 865:458-462.
    • (1998) Ann N Y Acad Sci , vol.865 , pp. 458-462
    • Rodier, G.1    Magous, R.2    Mochizuki, T.3
  • 41
    • 0032919561 scopus 로고    scopus 로고
    • Glicentin and oxyntomodulin modulate both the phosphoinositide and cyclic adenosine monophosphate signaling pathways in gastric myocytes
    • Rodier G, Magous R, Mochizuki T, et al. Glicentin and oxyntomodulin modulate both the phosphoinositide and cyclic adenosine monophosphate signaling pathways in gastric myocytes. Endocrinology 1999; 140:22-28.
    • (1999) Endocrinology , vol.140 , pp. 22-28
    • Rodier, G.1    Magous, R.2    Mochizuki, T.3
  • 42
    • 4344634754 scopus 로고    scopus 로고
    • Oxyntomodulin and glicentin are potent inhibitors of the fed motility pattern in small intestine
    • Pellissier S, Sasaki K, Le Nguyen D, et al. Oxyntomodulin and glicentin are potent inhibitors of the fed motility pattern in small intestine. Neurogastroenterol Motil 2004; 16:455-463. In vivo studies looking at the myoelectric effects of OXM on the smooth muscle of the stomach and small intestine, demonstrating the clear effects of the peptide on gut motility.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 455-463
    • Pellissier, S.1    Sasaki, K.2    Le Nguyen, D.3
  • 43
    • 0023910424 scopus 로고
    • Oxyntomodulin (glicentin-(33-69)): Pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
    • Baldissera FG, Holst JJ, Knuhtsen S, et al. Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul Pept 1988; 21:151-166.
    • (1988) Regul Pept , vol.21 , pp. 151-166
    • Baldissera, F.G.1    Holst, J.J.2    Knuhtsen, S.3
  • 44
    • 0028151905 scopus 로고
    • Rat parietal cell receptors for GLP-1-(7-36) amide: Northern blot, cross-linking, and radioligand binding
    • Schmidtler J, Dehne K, Allescher HD, et al. Rat parietal cell receptors for GLP-1-(7-36) amide: northern blot, cross-linking, and radioligand binding. Am J Physiol 1994; 267:G423-G432.
    • (1994) Am J Physiol , vol.267
    • Schmidtler, J.1    Dehne, K.2    Allescher, H.D.3
  • 45
    • 0028358615 scopus 로고
    • Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39)
    • Fehmann HC, Jiang J, Schweinfurth J, et al. Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39). Peptides 1994; 15:453-456.
    • (1994) Peptides , vol.15 , pp. 453-456
    • Fehmann, H.C.1    Jiang, J.2    Schweinfurth, J.3
  • 46
    • 0027220436 scopus 로고
    • Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line
    • Gros L, Thorens B, Bataille D, Kervran A. Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line. Endocrinology 1993; 133:631-638.
    • (1993) Endocrinology , vol.133 , pp. 631-638
    • Gros, L.1    Thorens, B.2    Bataille, D.3    Kervran, A.4
  • 47
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379:69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 48
    • 0026610768 scopus 로고
    • N-acetyl oxyntomodulin30-37: Pharmacokinetics and activity on gastric acid secretion
    • Carles-Bonnet C, Jarrousse C, Niel H, et al. N-acetyl oxyntomodulin30-37: pharmacokinetics and activity on gastric acid secretion. Naunyn Schmiedebergs Arch Pharmacol 1992; 345:57-63.
    • (1992) Naunyn Schmiedebergs Arch Pharmacol , vol.345 , pp. 57-63
    • Carles-Bonnet, C.1    Jarrousse, C.2    Niel, H.3


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