Role of breast milk in acquisition of cytomegalovirus infection: Recent advances

Current Opinion in Pediatrics

Volumn 18, Issue 1, 2006, Pages 48-52

  Schleiss, Mark R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Antiviral therapy; Breast milk; Congenital cytomegalovirus infection; Cytomegalovirus; Ganciclovir; Human milk; Lactation

Indexed keywords

ANTIVIRUS AGENT; GANCICLOVIR; NUCLEOSIDE DERIVATIVE;

BREAST FEEDING; BREAST MILK; CYTOMEGALOVIRUS INFECTION; DISEASE PREDISPOSITION; EPIDEMIOLOGICAL DATA; FREEZING; HEPATITIS; HIGH RISK PATIENT; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RATE; INFECTION RISK; LACTATION; LOW BIRTH WEIGHT; NEUTROPENIA; NEWBORN INFECTION; PASTEURIZATION; POLYMERASE CHAIN REACTION; PREMATURITY; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SEPSIS; SERODIAGNOSIS; THAWING; THROMBOCYTOPENIA; VERTICAL TRANSMISSION; VIRUS CULTURE; VIRUS INFECTIVITY; VIRUS SHEDDING; VIRUS TRANSMISSION; CYTOMEGALIC INCLUSION BODY DISEASE; DISEASE TRANSMISSION; NEWBORN; VIROLOGY;

BREAST FEEDING; CYTOMEGALOVIRUS INFECTIONS; DISEASE TRANSMISSION, VERTICAL; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MILK, HUMAN; POLYMERASE CHAIN REACTION;

EID: 33646897873     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mop.0000192520.48411.fa     Document Type: Review

References (30)

1. Whitley RJ. Congenital cytomegalovirus infection: epidemiology and treatment. Adv Exp Med Biol 2004; 549:155-160. A comprehensive recent review of the epidemiology and therapy of congenital cytomegalovirus infection.
2. Griffiths PD, Walter S. Cytomegalovirus. Curr Opin Infect Dis 2005; 18:241-245. A recent review of pathogenesis of congenital cytomegalovirus infection with emphasis on strategies, including vaccines, designed to interrupt transmission.
3. Noyola DE, Demmler GJ, Nelson CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 2001; 138:325-331.
4. Bale JF, Miner L, Petheram SJ. Congenital cytomegalovirus infection. Curr Treat Options Neurol 2002; 4:225-230.
5. Fowler KB, Dahle AJ, Boppana SB, et al. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed? J Pediatr 1999; 135:60-64.
6. Kimberlin DW, Lin CY, Sanchez PJ, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 2003; 143:16-25.
7. Schleiss MR. Vertically transmitted herpesvirus infections. Herpes 2003; 10:4-11.
8. Diosi P, Babusceac L, Nevinglovschi O, et al. Cytomegalovirus infection associated with pregnancy. Lancet 1967; 2:1063-1066.
9. Hayes K, Danks DM, Gibas H, et al. Cytomegalovirus in human milk. N Engl J Med 1972; 287:177-178.
10. Stagno S, Reynolds DW, Pass RF, et al. Breast milk and the risk of cytomegalovirus infection. N Engl J Med 1980; 302:1073-1076.
11. Dworsky M, Yow M, Stagno S, et al. Cytomegalovirus infection of breast milk and transmission in infancy. Pediatrics 1983; 72:295-299.
12. Vochem M, Hamprecht K, Jahn G, et al. Transmission of cytomegalovirus to preterm infants through breast milk. Pediatr Infect Dis J 1998; 17:53-58.
13. Hamprecht K, Maschmann J, Vochem M, et al. Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding. Lancet 2001; 357:513-518.
14. Maschmann J, Hamprecht, Dietz K, et al. Cytomegalovirus infection of extremely low-birth weight infants via breast milk. Clin Infect Dis 2001; 33:1998-2003.
15. Yasuda A, Kimura H, Hayakawa M, et al. Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay. Pediatrics 2003; 111:1333-1336.
16. Jim WT, Shu CH, Chiu NC, et al. Transmission of cytomegalovirus from mothers to preterm infants by breast milk. Pediatr Infect Dis J 2004; 23:848-851. A Taiwanese study indicating cytomegalovirus transmission, but low burden of disease, following fresh breast-milk feedings to high-risk preterm infants.
17. Meier J, Lienicke U, Tschirch E, et al. Human cytomegalovirus reactivation during lactation and mother-to-child transmission in preterm infants. J Clin Microbiol 2005; 43:1318-1324. A German study documenting reactivation of cytomegalovirus during lactation and subsequent feeding to preterm infants, which also suggests increased transmission occurs when fresh breast milk is the primary feeding source.
18. Doctor S, Friedman S, Dunn MS, et al. Cytomegalovirus transmission to extremely low-birthweight infants through breast milk. Acta Paediatr 2005; 94:53-58.
19. Miron D, Brosilow S, Felszer K, et al. Incidence and clinical manifestations of breast milk-acquired Cytomegalovirus infection in low birth weight infants. J Perinatol 2005; 25:299-303.
20. Welsh JK, Arsenakis M, Coelen RJ, et al. Effects of antiviral lipids, heat and freezing on the activity of viruses in human milk. J Infect Dis 1979; 140:322-328.
21. Ford JE, Law BA, Marshall VME, et al. Influence of the heat treatment of human milk on some of its protective constituents. J Pediatr 1982; 90:29-35.
22. Dworsky M, Stagno S, Pass RF, et al. Persistence of cytomegalovirus in human milk after storage. J Pediatr 1982; 101:440-443.
23. Friis H, Andersen HK. Rate of inactivation of cytomegalovirus in raw banked milk during storage at -20 degrees C and pasteurization. BMJ 1982; 285:1604-1605.
24. Sharland M, Khare M, Bedford-Russel A. Prevention of postnatal cytomegalovirus infection in preterm infants. Arch Dis Child Fetal Neonatal Ed 2002; 86:F140.
25. Hamprecht K, Maschmann J, Muller D, et al. Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing. Pediatr Res 2004; 56:529-535. Elegant and integrative clinical and laboratory based studies from the Tubigen group of investigators examining the mechanism(s) by which pasteurization and freeze-thaw may impact viral infectivity, and the immunologic and nutritional implications of these treatments.
26. Schleiss MR, McVoy MA. Overview of congenitally and perinatally acquired cytomegalovirus infections: recent advances in antiviral therapy. Expert Rev Anti Infect Ther 2004; 2:389-403.
27. Schanler RJ. CMV acquisition in premature infants fed human milk: reason to worry? J Perinatol 2005; 25:297-298. A thoughtful editorial weighing the pros and cons of exploring strategies to reduce breast-milk transmission of cytomegalovirus.
28. Willeitner A. Transmission of cytomegalovirus (CMV) through human milk: are new breastfeeding policies required for preterm infants? Adv Exp Med Biol 2004; 554:489-494. An overview of recommendations and controversies regarding what changes in breast-milk feeding practice, if any, should be considered in light of the risks of cytomegalovirus transmission via milk.
29. Newburg DS, Ruiz-Palacios GM, Morrow AL. Human milk glycans protect infants against enteric pathogens. Annu Rev Nutr 2005; 25:37-58. A review of mechanisms by which human milk prevents infection, including novel mechanisms mediated by glycans. The potential risks of cytomegalovirus transmission must be weighed against the known benefits of breast-feeding.
30. Vollmer B, Seibold-Weiger K, Schmitz-Salue C, et al. Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infants. Pediatr Infect Dis J 2004; 23:322-327. A case-control study of neonatal intensive care unit 'graduates' suggests that postnatal acquistion of cytomegalovirus via breast milk does not appear to confer a risk of hearing loss or neurodevelopmental disability.