Maintenance infliximab does not result in increased abscess development in fistulizing Crohn's disease: Results from the ACCENT II study

Alimentary Pharmacology and Therapeutics

Volumn 23, Issue 8, 2006, Pages 1127-1136

  Sands, B E ^a   Blank, M A ^b   Diamond, R H ^b   Barrett, J P ^b   Van Deventer, S J ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b CENTOCOR INC   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; INFLIXIMAB; PLACEBO;

ABSCESS; ADULT; ARTICLE; BRONCHITIS; CANDIDIASIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; FEMALE; FISTULA; GASTROINTESTINAL SYMPTOM; HUMAN; MAINTENANCE THERAPY; MALE; OUTCOME ASSESSMENT; PHARYNGITIS; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION;

ABSCESS; ADULT; ANTIBODIES, MONOCLONAL; CHI-SQUARE DISTRIBUTION; CROHN DISEASE; CROSS-OVER STUDIES; DATA INTERPRETATION, STATISTICAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; INFUSIONS, INTRAVENOUS; INTESTINAL DISEASES; INTESTINAL FISTULA; MALE; TIME FACTORS; TREATMENT OUTCOME;

EID: 33646883499     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2006.02878.x     Document Type: Article

References (14)

1. Lichtenstein GR. Treatment of fistulizing Crohn's disease. Gastroenterology 2000 119 : 1132 47.
2. West R Scott NA. Abdominal fistulizing Crohn's disease. In : Satsangi J Sutherland LR Colombel JF Fiocchi C Lofberg R Pemberton J Rutgeerts P, eds. Inflammatory Bowel Diseases. London, UK : Churchill Livingstone, Elsevier Limited, 2003 : 589 603.
3. Levy C Tremaine WJ. Management of internal fistulas in Crohn's disease. Inflamm Bowel Dis 2002 8 : 106 11.
4. Present DH. Crohn's fistula: current concepts in management. Gastroenterology 2003 124 : 1629 35.
5. Present DH Rutgeerts P Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999 340 : 1398 405.
6. Regueiro M Mardini H. Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 2003 9 : 98 103.
7. Bell SJ Halligan S Windsor ACJ Williams AB Wiesel P Kamm MA. Response of fistulating Crohn's disease to infliximab treatment assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2003 17 : 387 93.
8. van Bodegraven AA Sloots CE Felt-Bersma RJ, et al. Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response. Dis Colon Rectum 2002 45 : 39 46.
9. Van Assche G Vanbeckevoort D Bielen D, et al. Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease. Am J Gastroenterol 2003 98 : 332 9.
10. Sands BE Anderson FH Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004 350 : 876 85.
11. Sands BE Blank MA Patel K Van Deventer SJ. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2004 2 : 912 20.
12. Agrawal A Durrani S Leiper K Ellis A Morris A Rhodes J. Effect of systemic corticosteroid therapy on risk for intra-abdominal or pelvic abscess in non-operated Crohn's disease. Clin Gastroenterol Hepatol 2005 3 : 1215 20.
13. Lichtenstein GR Cohen RD Feagan BG, et al. Safety of infliximab and other Crohn's disease therapies - updated TREAT Registry data with over 10,000 patient-years of follow-up. Gastroenterology 2005 128 : A-580 (Abstract W1034).
14. Lichtenstein GR Yan S Bala M Blank M Sands B. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease. Gastroenterology 2005 128 : 862 9.