Heatstroke in small animal medicine: A clinical practice review

Journal of Veterinary Emergency and Critical Care

Volumn 16, Issue 2, 2006, Pages 112-119

  Johnson, Scott I ^a,d   McMichael, Maureen ^b   White, George ^c  

^a Emergency Animal Hospital of Northwest Austin   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c Animal Emergency and Referral Center   (United States)

^d NONE   (United States)

Author keywords

Acclimatization; Acute phase response; Coagulopathy; Heat shock proteins; Multiple organ dysfunction; Thermoregulation

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 33646863258     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/j.1476-4431.2006.00191.x     Document Type: Review

References (50)

1. Holloway S. Heatstroke in dogs. Comp Cont Educ 1992 14 12 : 1598 1604.
2. Wexler RK. Evaluation and treatment of heat-related illnesses. Am Fam Physician 2002 65 11 : 2307 2314.
3. Pechlaner C, Kaneider NC, Djanani A, et al. Antithrombin and near-fatal exertional heat stroke. Acta Med Austriaca 2002 29 3 : 107 111.
4. Lu KC, Wang JY, Lin SH, et al. Role of circulating cytokines and chemokines in exertional heatstroke. Crit Care Med 2004 32 2 : 399 403.
5. Knochel JP, Reed G. Disorders of heat regulation, In : Narins RG. ed. Maxwell & Kleeman's Disorders of Fluid and Electrolyte Metabolism, 5th edn. New York : McGraw-Hill 1994, pp. 1549 1590.
6. Bouchama A, Bridey F, Hammami MM, et al. Activation of coagulation and fibrinolysis in heatstroke. Thromb Haemost 1996 76 6 : 909 915.
7. Bouchama A, Knochel JP. Heat stroke. N Engl J Med 2002 346 25 : 1978 1988.
8. Flournoy S, Wohl J, Macintire DK. Heatstroke in dogs : pathophysiology and predisposing factors. Comp Cont Educ 2003 25 6 : 410 417.
9. Buckley IK. A light and electron microscopic study of thermally injured cultured cells. Lab Invest 1972 26 2 : 201 209.
10. Drobatz KJ, Macintire DK. Heat-induced illness in dogs : 42 cases (1976-1993). J Am Vet Med Assoc 1996 209 11 : 1894 1899.
11. Bouchama A, Parhar RS, el-Yazigi A, et al. Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J Appl Physiol 1991 70 6 : 2640 2644.
12. Bouchama A, al-Sedairy S, Siddiqui S, et al. Elevated pyrogenic cytokines in heatstroke. Chest 1993 104 5 : 1498 1502.
13. Johnson K. Pathophysiology of heatstroke. Comp Cont Educ 1982 4 2 : 141 144.
14. Bouchama A, Hammami MM, Haq A, et al. Evidence for endothelial cell activation/injury in heatstroke. Crit Care Med 1996 24 7 : 1173 1178.
15. Wang AY, Li PK, Lui SF, et al. Renal failure and heatstroke. Ren Fail 1995 17 2 : 171 179.
16. Kushner I, Rzewnciki D. Acute phase response, In : Gallin JI, Snyderman R. eds. Inflammation: Basic Principles and Clinical Correlates, 3rd edn. Philadelphia : Lippincott Williams & Wilkins 1999, pp. 317 329.
17. Fields PA. Review : protein function at thermal extremes: balancing stability and flexibility. Comp Biochem Physiol 2001 129 : 417 431.
18. Christians ES, Yan LJ, Benjamin IJ. Heat shock factor 1 and heat shock proteins : critical partners in protection against acute cell injury. Crit Care Med 2002 30 1 Suppl. : S43 S50.
19. Musch MW, Petrof EO, Kojima K, et al. Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun 2004 72 6 : 3187 3194.
20. Wen HC, Lee CC, Lee WC, et al. Chronic hypoxia preconditioning increases survival in rats suffering from heatstroke. Clin Exp Pharmacol Physiol 2002 29 5-6 : 435 440.
21. Yang YL, Lin MT. Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke. Am J Physiol 1999 276 6 Part 2 : H1961 H1967.
22. Yang YL, Lu KT, Tsay HJ, et al. Heat shock protein expression protects against death following exposure to heatstroke in rats. Neurosci Lett 1998 252 1 : 9 12.
23. Hammami MM, Bouchama A, al-Sedairy S, et al. Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heatstress. Crit Care Med 1997 25 8 : 1314 1319.
24. Hammami MM, Bouchama A, Shail E, et al. Elevated serum level of soluble interleukin-2 receptor in heatstroke. Intensive Care Med 1998 24 9 : 988.
25. Shephard RJ, Shek PN. Immune dysfunction as a factor in heat illness. Crit Rev Immunol 1999 19 4 : 285 302.
26. Gathiram P, Wells MT, Brock-Utne JG, et al. Portal and systemic arterial plasma lipopolysaccharide concentrations in heat stressed primates. Circ Shock 1988 25 : 223 230.
27. Cummings M. Increased c-fos expression associated with hyperthermia-induced apoptosis of a Burkitt lymphoma cell line. Int J Radiat Biol 1995 68 6 : 687 692.
28. Sakaguchi Y, Stephens LC, Makino M, et al. Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats. Cancer Res 1995 55 22 : 5459 5464.
29. Strother SV, Bull JM, Branham SA. Activation of coagulation during therapeutic whole body hyperthermia. Thromb Res 1986 43 3 : 353 360.
30. Knochel JP. Heat stroke and related heat stress disorders. Dis Mon 1989 35 5 : 301 377.
31. Flournoy S, Macintire DK, Wohl J. Heatstroke in dogs : clinical signs, treatment, prognosis, and prevention. Comp Cont Educ Pract Vet 2003 25 9 : 422 431.
32. Pawlinski R, Mackman N. Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Crit Care Med 2004 32 5 Suppl. : S293 S297.
33. Navari R, Sheehy T, McLean B, et al. The peripheral blood smear in heatstroke : an aid to diagnosis. Ala J Med Sci 1983 20 2 : 137 140.
34. Khogali M. Evaluation and treatment of heat-related illnesses. Am Fam Physician 2003 67 7 : 1439 1440.
35. Lagutkchik M, Ogilvie G, Hackett T, Wingfield W. Increased lactate concentrations in ill and injured dogs. J Vet Emerg Crit Care 1998 8 2 : 117 127.
36. Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004 32 8 : 1637 1642.
37. Stowell CP. What ever happened to blood substitutes? Transfusion 2004 44 10 : 1403 1404.
38. Buehler PW, Alayash AI. Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion 2004 44 10 : 1516 1530.
39. Thijs LG. Coagulation inhibitor replacement in sepsis is a potentially useful clinical approach. Crit Care Med 2000 28 9 Suppl. : S68 S73.
40. Warren BL, Eid A, Singer P, et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. J Am Med Assoc 2001 286 15 : 1869 1878.
41. Zausinger S, Westermaier T, Plesnila N, et al. Neuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia : comparison with customary therapeutic regimen. Stroke 2003 34 6 : 1526 1532.
42. Mathews K. Renal and urinary tract emergencies, In : King L, Hammond R. eds. Manual of Canine and Feline Emergency and Critical Care. Shurdington, Cheltenham : British Small Animal Veterinary Association 1999, pp. 87 99.
43. Plumb D. Veterinary Drug Handbook, 4th edn. White Bear Lake, Minnesota : Pharma Vet Publishing 2002, p. 498.
44. Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med 2000 28 9 : 3301 3313.
45. Oliveira RP, Velasco I, Soriano F, et al. Clinical review : hypertonic saline resuscitation in sepsis. Crit Care 2002 6 5 : 418 423.
46. Kuo JR, Lin CL, Chio CC, et al. Effects of hypertonic (3%) saline in rats with circulatory shock and cerebral ischemia after heatstroke. Intensive Care Med 2003 29 9 : 1567 1573.
47. Hughes D. Fluid therapy, In : King L, Hammond R. eds. Manual of Canine and Feline Emergency and Critical Care. Shurdington, Cheltenham : British Small Animal Veterinary Association 1999, pp. 7 22.
48. Cassutto B, Gfeller RW. Use of intravenous lidocaine to prevent reperfusion injury and subsequent multiple organ dysfunction syndrome. J Vet Emerg Crit Care 2003 13 3 : 137 148.
49. Yang CY, Lin MT. Oxidative stress in rats with heatstroke-induced cerebral ischemia. Stroke 2002 33 3 : 790 794.
50. Chou YT, Lai ST, Lee CC, et al. Hypothermia attenuates circulatory shock and cerebral ischemia in experimental heatstroke. Shock 2003 19 4 : 388 393.