Replacement of unfractionated heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia [2]

Blood

Volumn 106, Issue 8, 2005, Pages 2921-2922

  Greinacher, Andreas ^a   Eichler, Petra ^b   Lietz, Theresia ^b   Warkentin, Theodore E ^b  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; HUMAN; KNEE ARTHROPLASTY; LETTER; MAJOR CLINICAL STUDY; ORTHOPEDIC SURGERY; PRIORITY JOURNAL; SEROLOGY; STATISTICAL SIGNIFICANCE; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; THROMBOSIS; TOTAL HIP PROSTHESIS;

EID: 27144489083     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-05-1824     Document Type: Letter

References (6)

1. Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 2001;344:1286-1292.
2. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med. 1995;332:1330-1335.
3. Greinacher A, Michels I, Kiefel V, Mueller-Eckhardt C. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost 1991;66:734-736.
4. Visentin GP, Moghaddam M, Beery SE, McFarland JG, Aster RH. Heparin is not required for detection of antibodies associated with heparin-induced thrombocytopenia/thrombosis. J Lab Clin Med. 2001;138:22-31.
5. Ganzer D, Gutezeit A, Mayer G. Gefahrenpotentiale in der medikamentösen thromboseprophylaxe-niedermolekuläre heparine versus standardheparin. Z Orthop Ihre Grenzgeb. 1999;137:457-461.
6. Hach-Wunderle V, Kainer K, Krug B, Mueller-Berghaus G, Poetzsch B. Heparin-associated thrombosis despite normal platelet counts [letter]. Lancet 1994;344:469-470.