Rapid and sensitive method for the determination of propylene oxide in cigarette mainstream smoke by gas chromatography-mass spectrometry

Journal of Chromatographic Science

Volumn 44, Issue 1, 2006, Pages 32-34

  Diekmann, Joerg ^a   Douda, Michael ^a   Rustemeier, Klaus ^a  

^a Philip Morris Research Laboratories GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPOXIDE; PROPYLENE OXIDE;

ARTICLE; MASS FRAGMENTOGRAPHY; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SMOKE; STANDARD; TOBACCO;

EPOXY COMPOUNDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SMOKE; TOBACCO;

EID: 33646837002     PISSN: 00219665     EISSN: 00219665     Source Type: Journal    
DOI: 10.1093/chromsci/44.1.32     Document Type: Conference Paper

References (19)

1. IARC. "Propylene oxide". In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 60. Some Industrial Chemicals. International Agency for Research on Cancer, Lyon, France, 1994, pp. 181-213.
2. J.D. Heck, C.L. Gaworski, N. Rajendran, and R.L. Morrissey. Toxicologic evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats. Inhal. Toxicol. 14: 1135-52 (2002).
3. M.N. Ríos-Blanco, K. Plná, T. Faller, W. Kessler, K. Håkansson, P.E. Kreutzer, A. Ranasinghe, J.G. Filser, D. Segerbäck, and J.A. Swenberg. Propylene oxide: mutagenesis, carcinogenesis and molecular dose. Mutat. Res. 380: 179-97 (1997).
4. A. Kolman, M. Chovanec, and S. Osterman-Golkar. Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001). Mutat. Res. 512: 173-94 (2002).
5. J.J. Solomon, F. Mukai, J. Fedyk, and A. Segal. Reactions of propylene oxide with 2′-deoxynucleosides and in vitro with calf thymus DNA. Chem. Biol. Interact. 67: 275-94 (1988).
6. J. Bootman, D.C. Logde, and H.E. Whalley. Mutagenic activity of propylene oxide in bacterial and mammalian systems. Mutat. Res. 67: 101-12 (1979).
7. M.J.M. Nivard, K. Czene, D. Segerbäck, and E.W. Vogel. Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila. Mutat. Res. 529: 95-107 (2003).
8. M.R. Kagan, J.A. Cunningham, and D. Hoffmann. "Propylene glycol: a precursor of propylene oxide in cigarette smoke". 53rd Tobacco Chemist Research Conference, Montreal, Quebec, Canada, September 12-16, 1999. Program booklet and abstracts, Paper 41. 1999, p. 42 1999.
9. B.M. Gordon and W.M Coleman, III. "Determination of vinyl chloride, ethylene oxide and propylene oxide in fresh mainstream smoke via gas chromatography/mass spectrometry. 57th Tobacco Science Research Conference, Norfolk, VA, September 21-24, 2003. Program booklet and abstracts, Paper 63, 2003, p. 58.
10. H. Klus and H. Kuhn. Verteilung verschiedener tabakrauchbestandteile auf haupt- und nebenstromrauch (Eine Übersicht) Beitr. Tabakforsch. 11: 229-65 (1982).
11. M. Koskinen and K. Plná. Specific DNA adducts induced by some mono-substituted epoxides in vitro and in vivo. Chem. Biol. Interact. 129: 209-29 (2000).
12. E. Roemer, R. Stabbert, K. Rustemeier, D.J. Veltel, T.J. Meisgen, W. Reininghaus, R.A. Carchman, C.L. Gaworski, and K.F. Podraza. Chemical composition, cytotoxicity, and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions Toxicology 195: 31-52 (2004).
13. J.N. Diana and A. Vaught. Research Cigarettes. The University of Kentucky Printing Services, Lexington, KY, 1990.
14. H.M. Davies and A. Vaught. The Reference Cigarette. Kentucky Tobacco Research & Development Center, Lexington, KY, 2003.
15. International Standard ISO 3402. In Tobacco and Tobacco Products - Atmosphere for Conditioning and Testing, 3rd ed. International Organization for Standardization, Geneva, Switzerland, 1991.
16. International Standard ISO 3308. Cigarettes - Routine Analytical Cigarette Smoking Machine - Definitions and Standard Conditions, 3rd ed. International Organization for Standardization, Geneva, Switzerland, 1991.
17. G.D. Byrd, K.W. Fowler, R.D. Hicks, M.E. Lovette, and M.F. Borgerding. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke. J. Chromatogr. 503: 359-68 (1990).
18. J. Gilbert, J. Bush, A. Lopez de Sa, J.B.H. van Lierop, and X. Goenaga. Establishment of a reference collection of substances and an analytical handbook of reference data to support enforcement of EC regulations on food contact materials. Food Addit. Contam. 11: 71-77 (1994).
19. J.W. Munch and J.W. Eichelberger. Evaluation of 48 compounds for possible inclusion in U.S. EPA method 524.2, revision 3.0: expansion of the method analyte list to a total of 83 compounds. J. Chromatogr. Sci. 471: 471-77 (1992).