Cerebral Endothelial Nitric Oxide Synthase Expression is Reduced After Very Low Flow Bypass

Annals of Thoracic Surgery

Volumn 81, Issue 6, 2006, Pages 2202-2206

  Anttila, Vesa ^a,b   Christou, Helen ^a   Hagino, Ikuo ^a   Iwata, Yusuke ^c   Mettler, Bret A ^a   Fernandez Gonzalez, Angeles ^a   Zurakowski, David ^a   Jonas, Richard A ^c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c Children's National Medical Center   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; RHODAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MICROCIRCULATION; BRAIN PERFUSION; CARDIOPULMONARY BYPASS; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW RATE; FLUORESCENCE MICROSCOPY; HEMATOCRIT; HIGH TEMPERATURE; IMMUNOBLOTTING; INFLAMMATION; LEUKOCYTE; NONHUMAN; PARIETAL LOBE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; SWINE; VENULE;

ANIMALS; BLOTTING, WESTERN; CAPILLARIES; CARDIOPULMONARY BYPASS; CHEMOTAXIS, LEUKOCYTE; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; HEMORHEOLOGY; HYPOXIA-ISCHEMIA, BRAIN; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; NITRIC OXIDE SYNTHASE TYPE III; PARIETAL LOBE; REPERFUSION INJURY; SUS SCROFA; TEMPERATURE; VENULES;

EID: 33646836083     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2006.01.023     Document Type: Article

References (26)

1. Loscalzo J. Nitric oxide and vascular disease. N Engl J Med 333 (1995) 251-253
2. Rudic R.D., and Sessa W.C. Nitric oxide in endothelial dysfunction and vascular remodeling. clinical correlates and experimental links. Am J Hum Genet 64 (1999) 673-677
3. Samdani A.F., Dawson T.M., and Dawson V.L. Nitric oxide synthase in models of focal ischemia. Stroke 28 (1997) 1283-1288
4. Huang P.L., Huang Z., Mashimo H., et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377 (1995) 239-242
5. Gidday J.M., Park T.S., Shah A.R., and Gonzales E.R. Modulation of basal and postischemic leukocyte-endothelial adherence by nitric oxide. Stroke 29 (1998) 1423-1429
6. Hudetz A.G., Wood J.D., and Kampine J.P. Nitric oxide synthase inhibitor augments post-ischemic leukocyte adhesion in the cerebral microcirculation in vivo. Neurol Res 21 (1999) 378-384
7. Lindauer U., Dreier J., Angstwurm K., et al. Role of nitric oxide synthase inhibition in leukocyte-endothelium interaction in the rat pial microvasculature. J Cereb Blood Flow Metab 16 (1996) 1143-1152
8. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20 (1997) 132-139
9. Huang Z., Huang P.L., Ma J., et al. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab 16 (1996) 981-987
10. Dalkara T., Morikawa E., Panahian N., and Moskowitz M.A. Blood flow-dependent functional recovery in a rat model of focal cerebral ischemia. Am J Physiol 267 (1994) H678-H683
11. McQuillan L.P., Leung G.K., Marsden P.A., Kostyk S.K., and Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol 267 (1994) H1921-H1927
12. Liao J.K., Zulueta J.J., Yu F.S., Peng H.B., Cote C.G., and Hassoun P.M. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest 96 (1995) 2661-2666
13. Phelan M.W., and Faller D.V. Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol 167 (1996) 469-476
14. Arnet U.A., McMillan A., Dinerman J.L., Ballermann B., and Lowenstein C.J. Regulation of endothelial nitric-oxide synthase during hypoxia. J Biol Chem 271 (1996) 15069-15073
15. Endres M., Laufs U., Liao J.K., and Moskowitz M.A. Targeting eNOS for stroke protection. Trends Neurosci 27 (2004) 283-289
16. Iadecola C., Zhang F., Casey R., Clark H.B., and Ross M.E. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27 (1996) 1373-1380
17. Duebener L.F., Sakamoto T., Hatsuoka S., et al. Effects of hematocrit on cerebral microcirculation and tissue oxygenation during deep hypothermic bypass. Circulation 104 (2001) I260-I264
18. Wallenstein S., Zucker C.L., and Fleiss J.L. Some statistical methods useful in circulation research. Circ Res 47 (1980) 1-9
19. McCullagh P., and Nelder J.A. Generalized linear models. 2nd ed (1989), Chapman & Hall, New York
20. Chello M., Mastroroberto P., Romano R., Ascione R., Pantaleo D., and De Amicis V. Complement and neutrophil activation during cardiopulmonary bypass. a randomized comparison of hypothermic and normothermic circulation. Eur J Cardiothorac Surg 11 (1997) 162-168
21. Wagner F.M., Schiller W., Dilg G., Depner C., Welz A., and Lacour-Gayet F. Direct visualization of the influence of normothermic as opposed to hypothermic cardiopulmonary bypass on the systemic microcirculation in neonatal piglets. J Thorac Cardiovasc Surg 127 (2004) 1781-1788 Cardiol Young 2001;11:532-8.22. Anttila V, Hagino I, Zurakowski D, Lidov HG, Jonas RA. Higher bypass temperature correlates with increased white cell activation in the cerebral microcirculation
22. Rubanyi G.M., Ho E.H., Cantor E.H., Lumma W.C., and Botelho L.H. Cytoprotective function of nitric oxide. inactivation of superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 181 (1991) 1392-1397
23. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., and Freeman B.A. Apparent hydroxyl radical production by peroxynitrite. implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87 (1990) 1620-1624
24. Gaboury J., Woodman R.C., Granger D.N., Reinhardt P., and Kubes P. Nitric oxide prevents leukocyte adherence. role of superoxide. Am J Physiol 265 (1993) H862-H867
25. Serrano Jr. C.V., Mikhail E.A., Wang P., Noble B., Kuppusamy P., and Zweier J.L. Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart. Biochim Biophys Acta 3 (1996) 191-202
26. Kubes P., Suzuki M., and Granger D.N. Nitric oxide. an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A 88 (1991) 4651-4655