Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3605-3608

  Caturla, Francisco ^a   Amat, Mercè ^a   Reinoso, Raquel F ^a   Calaf, Elena ^a   Warrellow, Graham ^a  

^a Research Center ^*  (Spain)

Author keywords

COX 2; Prodrugs; Sulfoxides

Indexed keywords

4 PYRONE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; ETORICOXIB; PRODRUG; ROFECOXIB; SULFONE; SULFOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; ENANTIOMER; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; NONHUMAN; RACEMIZATION; RAT;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRODRUGS; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; SULFOXIDES;

EID: 33646826498     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.101     Document Type: Article

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