Structural analysis of mogrol and its glycosides as inhibitors of animal DNA polymerase and human cancer cell growth

Letters in Drug Design and Discovery

Volumn 3, Issue 4, 2006, Pages 253-260

  Mizushina, Yoshiyuki ^a   Akihisa, Toshihiro ^b   Hayakawa, Yousuke ^b   Takeuchi, Toshifumi ^c   Kuriyama, Isoko ^a   Yonezawa, Yuko ^a   Takemura, Masaharu ^d   Kato, Ikuo ^e   Sugawara, Fumio ^c   Yoshida, Hiromi ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d MIE UNIVERSITY   (Japan)

^e Yanaihara Institute Inc   (Japan)

Author keywords

Computer simulation; Cytotoxicity; DNA polymerase; Enzyme inhibitor; Mogrol; Mogroside; Mogroside I E1

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; DNA POLYMERASE INHIBITOR; GLUCOSE; GLYCOSIDE; MOGROL; MOGROSIDE 1 E1; MOGROSIDE DERIVATIVE; NUCLEOTIDYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CATALYST; CELL ACTIVITY; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 33646816337     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018006776743224     Document Type: Article

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