Relationship between Garcinia cambogia-induced impairment of spermatogenesis and meiosis-activating sterol production in rat testis

Journal of Clinical Biochemistry and Nutrition

Volumn 38, Issue 3, 2006, Pages 180-187

  Kiyose, Chikako ^a   Ogino, Satomi ^a   Kubo, Kazuhiro ^a   Takeuchi, Masaya ^b   Saito, Morio ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^b Sapporo General Pathology Laboratory   (Japan)

Author keywords

( ) hydroxycitric acid; Garcinia cambogia; Inhibin B; Spermatogenesis; Testis meiosis activating sterol

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CASEIN; CELLULOSE; CYSTEINE; FOLLITROPIN; GARCINIA CAMBOGIA EXTRACT; GLUCOSE; HYDROXYCITRIC ACID; INHIBIN B; LUTEINIZING HORMONE; PLANT EXTRACT; SOYBEAN OIL; STARCH; STEROL; SUCROSE; TERT BUTYLHYDROQUINONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIET; ENZYME INHIBITION; FOLLITROPIN BLOOD LEVEL; FOOD INTAKE; GARCINIA CAMBOGIA; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEIOSIS; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; TESTIS ATROPHY; TESTOSTERONE BLOOD LEVEL;

GARCINIA CAMBOGIA;

EID: 33646813689     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.38.180     Document Type: Article

References (17)

1. Lewis, Y.S. and Neelakantan, S.: (-)-Hydroxycitric acid-The principal acid in the fruits of Garcinia cambogia. Phytochemistry, 4, 619-625, 1965.
2. Cheema-Dhadli, S., Halperin, M.L., and Leznoff, C.C.: Inhibition of enzymes which interact with citrate by (-)-hydroxycitrate and 1,2,3-tricarboxybenzene. Eur. J. Biochem., 38, 98-102, 1973.
3. Lowenstein, J.M.: Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J. Biol. Chem., 246, 629-632, 1971.
4. Sullivan, A.C., Hamilton, J.G., Miller, O.N., and Wheatley, V.R.: Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch. Biochem. Biophy., 150, 183-190, 1972.
5. Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J., and Takeuchi, M.: High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem. Toxicol., 43, 411-419, 2005.
6. Tacer, K.F., Haugen, T.B., Baltsen, M., Debeljak, N., and Rozman, D.: Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meosis-activation sterol (T-MAS). J. Lipid Res., 43, 82-89, 2002.
7. Byskov, A.G., Andersen, C.Y., Nordholm, L., Thogersen, H., Guoliang, X., Wassmann, O., Andersen, J.V., Guddal, E., and Roed, T.: Chemical structure of sterols that activate oocyte meiosis. Nature, 374, 559-562, 1995.
8. Rozman, D., Coman, M., and Frngez, R.: Lanosterol 14α-demethylase and MAS sterols in mammalian gametogenesis. Mol. Cell. Endcrinol., 187, 179-187, 2002.
9. Grondahl, C., Ottessen, J.L., Lessl, M., Faarup, P., Murray, A., Gronvald, F.C., Hegele-Hartung, C., and Ahnfelt-Ronne, I.: Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols. Biol. Reprod., 58, 1297-1302, 1998.
10. Reeves, P.G., Nielsen, F.H., and Fahey, Jr. N.G.: AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr., 123, 1939-1951, 1993.
11. Pierik, F.H., Vreeburg, J.T.M., Stijnen, T., De Jong, F.H., and Weber, R.F.A.: Serum inhibin B as a marker of spermatogenesis. J. Clin. Endocrinol. Metab., 83, 3110-3114, 1998.
12. Jensen, T.K., Andersson, A.M., Hjollund, N.H.I., Scheike, T., Kolstad, H., Giwercman, A., Henriksen, T.B., Ernst, E., Bonde, J.P., Olsen, J., Mcneilly, A., Groome, N.P., and Skakkebaek, N.E.: Inhibin B as a serum marker of spermatogenesis: Correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J. Clin. Endocrinol. Metab., 82, 4059-4063, 1997.
13. Illingworth, P.J., Groome, N.P., Byrd, W., Rainey, W.E., Mcneilly, A.S., Mather, J.P., and Bremner, W.J.: Inhibin-B: Likely candidate for the physiologically important form of inhibin in men. J. Clin. Endocrinol. Metab., 81, 1321-1325, 1996.
14. Anderson, R.A., Wallance, E.M., Groome, N.P., Bellis, A.J., and Wu, F.C.W.: Physiological relationships between inhibin B, follicle stimulating hormone secretion and spermatogenesis in normal men and response to gonadotrophin suppression by exogenous testosterone. Hum. Reprod., 12, 746-751, 1997.
15. Pierik, F.H., Burdorf, A., De Jong, F.H., and Weber, R.F.A.: Inhibin B: a novel marker of spermatogenesis. Ann. Med., 35, 12-20, 2003.
16. Sekita, K., Ogawa, Y., Kitajima, S., Saito, Y., Nagata, T., Inoue, T., and Kanno, J.: Toxicity study of Garcinia cambogia extract. II.: A 28-day dietary exposure of hydroxycitric acid, a principal ingredient of Garcinia cambogia extract, on tesicular toxicity in rats. J. Toxicol. Sci., 28, 294 (Abstract), 2003.
17. Cross, N.L.: Role of cholesterol in sperm capacitation. Biol. Reprod., 5, 7-11, 1998.