Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgrounds

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 606, Issue 1-2, 2006, Pages 12-20

  Hernández, Alba ^a   Xamena, Noel ^a   Gutiérrez, Sara ^b   Velázquez, Antonia ^a   Creus, Amadeu ^a   Surrallés, Jordi ^a   Galofré, Pere ^c   Marcos, Ricardo ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

Genotoxicity; GST and NAT polymorphisms; Micronuclei; Thyroid cancer

Indexed keywords

ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; RADIOACTIVE IODINE;

ACETYLATOR PHENOTYPE; ADULT; ALLELE; ARTICLE; CANCER ADJUVANT THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME POLYMORPHISM; EXPLORATORY RESEARCH; FEMALE; GENOTOXICITY; HUMAN; IONIZING RADIATION; LYMPHOCYTE; MALE; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION EXPOSURE; THYROID CANCER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; ARYLAMINE N-ACETYLTRANSFERASE; CHILD; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; POLYMORPHISM, GENETIC; THYROID NEOPLASMS;

EID: 33646803519     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.02.002     Document Type: Article

References (65)

1. Taningher M., Malacarne D., Izzotti A., Ugolini D., and Parodi S. Drug metabolism polymorphisms as modulators of cancer susceptibility. Mutat. Res. 436 (1999) 227-261
2. Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat. Res. 463 (2000) 247-283
3. Hengstler J.G., Arand M., Herrero M.E., and Oesch F. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res. 154 (1998) 47-85
4. Hashibe M., Brennan P., Strange R.C., Bhisey R., Cascorbi I., Lazarus P., Oude Ophuis M.B., Benhamou S., Foulkes W.D., Katoh T., Coutelle C., Romkes M., Gaspari L., Taioli E., and Boffetta P. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol. Biomark. Prev. 12 (2003) 1509-1517
5. Norppa H. Genetic susceptibility, biomarker respones, and cancer. Mutat. Res. 544 (2003) 339-348
6. Habdous M., Siest G., Herbeth B., Vincent-Viry M., and Visvikis S. Glutathione S-transferases genetic polymorphisms and human diseases: overview of epidemiological studies. Ann. Biol. Clin. 62 (2004) 15-24
7. Vogl F.D., Taioli E., Maugard C., Zheng W., Pinto L.F., Ambrosone C., Parl F.F., Nedelcheva-Kristensen V., Rebbeck T.R., Brennan P., and Boffetta P. Glutathione S-transferases M1, T1, and P1 and breast cancer: a pooled analysis. Cancer Epidemiol. Biomark. Prev. 13 (2004) 1473-1479
8. Garcia-Closas M., Malats N., Silverman D., Dosemeci M., Kogevinas M., Hein D.W., Tardon A., Serra C., Carrato A., Garcia-Closas R., Lloreta J., Castano-Vinyals G., Yeager M., Welch R., Chanock S., Chatterjee N., Wacholder S., Samanic C., Tora M., Fernandez F., Real F.X., and Rothman N. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 366 (2005) 649-659
9. Lai R., Crevier L., and Thabane L. Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. Cancer Epidemiol. Biomark. Prev. 14 (2005) 1784-1790
10. Ntais C., Polycarpou A., and Ioannidis J.P. Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis. Cancer Epidemiol. Biomark. Prev. 14 (2005) 176-181
11. Ye Z., and Song H. Glutathione S-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur. J. Cancer 41 (2005) 980-989
12. Hagmar L., Bonassi S., Strömberg U., Brøgger A., Knudsen L., Norppa H., Reuterwall C., Forni A., Hansteen I.-L., Högstedt B., Huici Montagud A., Lambert B., Mitelman F., Nordenson I., Salomaa S., and Skerfving S. Chromosomal aberrations in lymphocytes predict human cancer-a report from the European Study Group of Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58 (1998) 4117-4121
13. Akslen L.A., Haldorsen T., Thoresen S.O., and Glattre E. Survival and causes of death in thyroid cancer: a population based study of 2479 cases from Norway. Cancer Res. 51 (1991) 1234-1241
14. Ramírez M.J., Puerto S., Galofré P., Parry E.M., Parry J.M., Creus A., Marcos R., and Surrallés J. Multicolour FISH detection of radioactive iodine-induced 17cen-p53 chromosomal breakage in buccal cells from therapeutically exposed patients. Carcinogenesis 21 (2000) 1581-1586
15. Ramírez M.J., Surrallés J., Galofré P., Creus A., and Marcos R. Radioactive iodine induces clastogenic and age-dependent aneugenic effects in lymphocytes of thyroid cancer patients as revealed by interphase FISH. Mutagenesis 12 (1997) 449-455
16. Ron E., and Modan B. Thyroid. In: Schottenfeld D., and Fraumeni J. (Eds). Cancer Epidemiology and Prevention (1982), Saunders, Philadelphia, PA 837-854
17. Kingman S. Thyroid cancer rises after Chernobyl. Br. Med. J. 305 (1992) 601-602
18. Galanti M.R., Sparén P., Karlsson A., Grimelius L., and Ekbom A. Is residence in areas of endemic goiter a risk factor for thyroid cancer?. Int. J. Cancer 61 (1995) 615-621
19. Dušinská M., Ficek A., Horská A., Rašlová K., Petrovská H., Vallová B., Drlicková M., Wood S.G., Štupáková A., Gašparovic J., Bobek P., Nagyová A., Kováciková Z., Blazicek P., Liegebel U., and Collins A.R. Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans. Mutat. Res. 482 (2001) 47-55
20. Kassayova M., Ahlersova E., and Ahlers I. Changes of pineal N-acetyltransferase activity in gamma irradiated rats. Physiol. Res. 42 (1993) 167-169
21. Hernández A., Céspedes W., Xamena N., Surrallés J., Creus A., Galofré P., and Marcos R. Glutathione S-transferase polymorphisms in thyroid cancer patients. Cancer Lett. 190 (2003) 37-44
22. Hein D.W., Doll M.A., Fretland A.J., Left M.A., Webb S.J., Xiao G.H., Devanaboyina U.S., Nangju N.A., and Feng Y. Molecular genetics and epidemiology of the NAT1 and Nat2 acetylation polymorphisms. Cancer Epidemiol. Biomark. Prev. 9 (2000) 29-42
23. Surrallés J., Antoccia A., Creus A., Degrassi F., Peris F., Tanzarella C., Xamena N., and Marcos R. The effect of cytochalasin-B concentration on the frequency of micronuclei induced by four standard mutagens. Results from two laboratories. Mutagenesis 9 (1994) 347-353
24. 131I. Cancer Lett. 91 (1995) 199-204
25. 131I exposure. Study in hyperthyroidism patients. Mutat. Res. 373 (1997) 39-45
26. Gutiérrez S., Carbonell E., Galofré P., Creus A., and Marcos R. Cytogenetic damage after 131-iodine treatment for hyperthyroidism and thyroid cancer. A study using the micronucleus test. Eur. J. Nucl. Med. 26 (1999) 1589-1596
27. Garte S., Gaspari L., Alexandrie A.K., Ambrosone C., Autrup H., Autrup J.L., Baranova H., Bathum L., Benhamou S., Boffetta P., Bouchardy C., Breskvar K., Brockmoller J., Cascorbi I., Clapper M.L., Coutelle C., Daly A., Dell'Omo M., Dolzan V., Dresler C.M., Fryer A., Haugen A., Hein D.W., Hildesheim A., Hirvonen A., Hsieh L.L., Ingelman-Sundberg M., Kalina I., Kang D., Kihara M., Kiyohara C., Kremers P., Lazarus P., Le Marchand L., Lechner M.C., van Lieshout E.M., London S., Manni J.J., Maugard C.M., Morita S., Nazar-Stewart V., Noda K., Oda Y., Parl F.F., Pastorelli R., Persson I., Peters W.H., Rannug A., Rebbeck T., Risch A., Roelandt L., Romkes M., Ryberg D., Salagovic J., Schoket B., Seidegard J., Shields P.G., Sim E., Sinnet D., Strange R.C., Stucker I., Sugimura H., To-Figueras J., Vineis P., Yu M.C., and Taioli E. Metabolic gene polymorphism frequencies in control studies. Cancer Epidemiol. Biomark. Prev. 10 (2001) 1239-1248
28. Fontana X., Peyrotte I., Valente E., Rossi C., Ettore F., Namer M., and Bussier F. Glutathion S-transférase mu 1 (GSTM1): gene de susceptibilité du cancer du sein. Bull. Cancer 84 (1997) 35-40
29. Rydberg D., Skaug V., Hewer A., Phillips D.H., Harries L.W., Wolf C.R., Ogreid D., Ulvik A., Vu P., and Haugen A. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis 18 (1997) 1285-1289
30. Rocha L., García C., de Mendonça A., Gil J.P., Bishop D.T., and Lechner M.C. N-acetyltransferase (NAT2) genotype and susceptibility to sporadic Alzheimer's disease. Pharmacogenetics 9 (1999) 9-15
31. Korpinen E., Groop P.-H., Rautio A., Madácsy L., Reunanen A., Vaarala O., and Åkerblom H.K. N-acetyltransferase-2 polymorphism, smoking and type 1 diabetes nephropathy. Pharmacogenetics 9 (1999) 627-633
32. Hou S.M., Fält S., Yang K., Nyberg F., Pershagen G., Hemminki K., and Lambert B. Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequencies in lung cancer patients and population controls. Cancer Epidemiol. Biomark. Prev. 10 (2001) 133-140
33. Knudsen L.E., Norppa H., Gamborg M.O., Nielsen P.S., Okkels H., Soll-Johanning H., Raffin E., Järventaus H., and Autrup H. Chromosomal aberrations in humans induced by urban air pollution: influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2. Cancer Epidemiol. Prev. 8 (1999) 303-310
34. Norppa H. Genetic polymorphisms and chromosome damage. Int. J. Hyg. Environ. Health 204 (2001) 31-38
35. Fenech M. Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes-a biomarker for DNA damage in human populations. Mutat. Res. 404 (1998) 155-165
36. Aka P., Mateuca R., Buchet J.P., Thierens H., and Kirsch-Volders M. Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?. Mutat. Res. 556 (2004) 169-181
37. Angelini S., Kumar R., Carbone F., Maffei F., Forti G.C., Violante F.S., Lodi V., Curti S., Hemminki K., and Hrelia P. Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes. Mutat. Res. 570 (2005) 105-117
38. Sram R.J., Rossner P., Rubes J., Beskid O., Dusek Z., Chvatalova I., Schmuczerova J., Milcova A., Solansky I., Bavorova H., Ocadlikova D., Kopecna O., and Musilova P. Possible genetic damage in the Czech nuclear power plant workers. Mutat. Res. 593 (2006) 50-63
39. Norppa H. Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes. Environ. Health Perspect. 105 (1997) 829-835
40. Norppa H. Cytogenetic biomarkers and genetic polymorphisms. Tox. Lett. 149 (2004) 309-334
41. Bonassi S., Ugolini D., Kirsch-Volders M., Stromberg U., Vermeulen R., and Tucker J.D. Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ. Mol. Mutagen. 45 (2005) 258-270
42. Frazier M.L., O'Donell F.T., Kong S., Gu X., Campos I., Luthra R., Lynch P.M., and Amos C.I. Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. Cancer Res. 61 (2001) 1269-1271
43. Uusküla M., Järventaus H., Hirvonen A., Sorsa M., and Norppa H. Influence of GSTM1 genotype on sister chromatid exchange induction by styrene 7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes. Carcinogenesis 16 (1995) 947-950
44. Bernardini S., Hirvonen A., Pelin K., and Norppa H. Induction of sister chromatid exchanges by 1,2-epoxy-3-butene in cultured human lymphocytes: influence of GSTT1 genotype. Carcinogenesis 19 (1998) 377-380
45. Kelsey K.T., Wiencke J.K., Ward J., Bechtold W., and Fajen J. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat. Res. 335 (1995) 267-273
46. Falck G., Hirvonen A., Scarpato R., Saarikoski S.T., Migliore L., and Norppa H. Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. Mutat. Res. 441 (1999) 225-237
47. Lucero L., Pastor S., Suárez S., Durbán R., Gómez C., Parrón T., Creus A., and Marcos R. Cytogenetic biomonitoring of Spanish greenhouse workers exposed to pesticides: micronuclei analysis in peripheral blood lymphocytes and buccal epithelial cells. Mutat. Res. 464 (2000) 255-262
48. Karahalil B., Sardas S., Kocabas N.A., Alhayiroglu E., Karakaya A.E., and Civelek E. Chromosomal aberrations under basal conditions and after treatment with X-ray in human lymphocytes as related to the GSTM1 genotype. Mutat. Res. 515 (2002) 135-140
49. Vos O., van der Schans G.P., and Roos-Verheij W.S. Reduction of intracellular glutathione content and radiosensitivity. Int. J. Radiat. Biol. 50 (1986) 155-165
50. Scarpato R., Migliore L., Hirvonen A., Falck G., and Norppa H. Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1 and NAT2 genotypes. Environ. Mol. Mutagen. 27 (1996) 263-269
51. Minchin R.F. Acetylation of p-aminobenzolglutamate, a folic acid catabolite, by recombinant human aylamine N-acetyltransferase and U937 cells. Biochem. J. 307 (1995) 1-3
52. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 389 (1997) 349-352
53. Seiler N., Knodgen B., and Bartholeyns J. Polyamine metabolism and polyamine excretion in normal and tumor bearing rodents. Anticancer Res. 5 (1985) 371-377
54. Chan A.T., Tranah G.J., Giovannucci E.L., Willett W.C., Hunter D.J., and Fuchs C.S. Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int. J. Cancer 115 (2005) 648-652
55. Chiou H.L., Wu M.F., Chien W.P., Cheng Y.W., Wong R.H., Chen C.Y., Lin T.S., and Lee H. NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan. Cancer Lett. 223 (2005) 93-101
56. Carreon T., Ruder A.M., Schulte P.A., Hayes R.B., Rothman N., Waters M., Grant D.J., Boissy R., Bell D.A., Kadlubar F.F., Hemstreet III G.P., Yin S., and LeMasters G.K. NAT2 slow acetylation and bladder cancer in workers exposed to benzidine. Int. J. Cancer 118 (2006) 161-168
57. Huang Y.S., Chern H.D., Wu J.C., Chao Y., Huang Y.H., Chang F.Y., and Lee S.D. Polymorphism of the N-acetyltransferase 2 gene, red meat intake, and the susceptibility of hepatocellular carcinoma. Am. J. Gastroenterol. 98 (2003) 1417-1422
58. Chen K., Jiang Q.T., and He H.Q. Relationship between metabolic enzyme polymorphism and colorectal cancer. World J. Gastroenterol. 11 (2005) 331-335
59. Ladero J.M., Agundez J.A., Olivera M., Lozano L., Rodriguez-Lescure A., Diaz-Rubio M., and Benitez J. N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma. Eur. J. Clin. Pharmacol. 58 (2002) 115-118
60. Prawan A., Kukongviriyapan V., Tassaneeyakul W., Pairojkul C., and Bhudhisawasdi V. Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma. Eur. J. Cancer Prev. 14 (2005) 245-250
61. Wainwright S.D., and Wainwright L.K. Effects of some inhibitors of DNA synthesis and repair upon the cycle of serotonin N-acetyltransferase activity in cultured chick pineal glands. Biochem. Cell Biol. 64 (1986) 344-355
62. Heinimann K., Scott R.J., Chappuis P., Weber W., Müller H., Dobbie Z., and Hutter P. N-acethyltransferase 2 influences cancer prevalence in hMLH1/hMSH2 mutation carriers. Cancer Res. 59 (1999) 3038-3040
63. Matullo G., Guarrera S., Carturan S., Peluso M., Malaveille C., Davico L., Piazza A., and Vineis P. DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study. Int. J. Cancer 92 (2001) 562-567
64. Price E.A., Bourne S.L., Radbourne R., Lawton P.A., Lamerdin J., Thompson L.H., and Arrand J.E. Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. Somat. Cell Mol. Genet. 23 (1997) 237-247
65. De Ruyck K., Wilding C.S., Van Eijkeren M., Morthier R., Tawn E.J., and Thierens H.M. Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. Radiat. Res. 164 (2005) 237-244