Nasal Dosimetry of Inhaled Gases and Particles: WherE Do Inhaled Agents Go in the Nose?

Toxicologic Pathology

Volumn 34, Issue 3, 2006, Pages 270-273

  Kimbell, J S ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

computational fluid dynamics; human; monkey; Nasal dosimetry; nasal passages; nose; particles; rat

Indexed keywords

FORMALDEHYDE;

ACCURACY; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; DOSE CALCULATION; FLOW RATE; FUNCTIONAL ANATOMY; HUMAN; INHALATION; MACACA; MICROSCOPIC ANATOMY; NONHUMAN; NOSE; NOSE AIRFLOW; NOSE BREATHING; NOSE CAVITY; NOSE IRRITATION; NOSE MUCOSA; NOSE SEPTUM; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; RAT; REST; RISK ASSESSMENT; SIMULATION; SPECIES DIFFERENCE; SQUAMOUS EPITHELIUM; TURBINATE;

ANIMALS; COMPUTER SIMULATION; FORMALDEHYDE; HUMANS; INHALATION EXPOSURE; MACACA MULATTA; MODELS, ANATOMIC; NASAL CAVITY; RATS; SPECIES SPECIFICITY;

ANIMALIA; MACACA;

EID: 33646789808     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230600695607     Document Type: Article

References (27)

1. Asgharian B, Anjilvel S Inertial and gravitational deposition of particles in a square cross section bifurcating airway Aerosol Sci and Technol 1994 20 177-93
2. Bird RB, Stewart WE, Lightfoot EN Transport Phenomena 1960 NY Wiley and Sons
3. Cohen Hubal EA, Schlosser PM, Conolly RB, Kimbell JS Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages Toxicol Appl Pharmacol 1997 143 47 55
4. Conolly RB, Kimbell JS, Janszen DB, Schlosser PM, Kalisak DL, Preston J, Miller FJ Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat Toxicol Sci 2003 75 432-47
5. Godo MN, Morgan KT, Richardson RB, Kimbell JS Reconstruction of complex passageways for simulations of transport phenomena: Development of a graphical user interface for biological applications Comp Meth Prog Biomed 1995 47 97 112
6. Hahn I, Scherer PW, Mozel MM Velocity profiles measured for airflow through a large-scale model of the human nasal cavity J Appl Physiol 1993 75 2273-87
7. Hotchkiss JA, Herrera LK, Harkema JR, Kimbell JS, Morgan KT, Hatch GE Regional differences in ozone-induced nasal epithelial cell proliferation in F344 rats: Comparison with computational mass flux predictions of ozone dosimetry Inhal Toxicol 1994 6 suppl 390-92
8. Kepler GM, Richardson RB, Morgan KT, Kimbell JS Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey Toxicol Appl Pharmacol 1998 150 1 11
9. Kimbell JS, Asgharian B, Wong BA, Segal RA, Schroeter JD, Southall JP, Brace G, Dickens CJ, Miller FJ Characterization of particle deposition and penetration from current nasal spray devices. Part II—Using a computational fluid dynamics (CFD) model of the human nasal passages J Aerosol Med 2003 16 2 205
10. Kimbell JS, Godo MN, Gross EA, Joyner DR, Richardson RB, Morgan KT Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages Toxicol Appl Pharmacol 1997a 145 388-98
11. Kimbell JS, Gross EA, Joyner DR, Godo MN, Morgan KT Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat Toxicol Appl Pharmacol 1993 121 253-63
12. Kimbell JS, Gross EA, Richardson RB, Conolly RB, Morgan KT Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages Mut Res 1997b 380 143-54
13. Kimbell JS, Overton JH, Subramaniam RP, Schlosser PM, Morgan KT, Conolly RB, Miller FJ Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment Toxicol Sci 2001b 64 111-21
14. Kimbell JS, Subramaniam RP, Gross EA, Schlosser PM, Morgan KT Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages Toxicol Sci 2001a 64 100-10
15. Klonne DR, Ulrich CE, Riley MG, Hamm TE Jr, Morgan KT, Barrow CS One-year inhalation toxicity study of chlorine in Rhesus monkeys (Macaca mulatta) Fundam Appl Toxicol 1987 9 557-72
16. Monticello TM, Morgan KT, Everitt JI, Popp JA Effects of formaldehyde gas on the respiratory tract of rhesus monkeys: pathology and cell proliferation Am J Pathol 1989 134 515-27
17. Monticello TM, Swenberg JA, Gross EA, Leininger JR, Kimbell JS, Seilkop S, Starr TB, Gibson JE, Morgan KT Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells Cancer Res 1996 56 1012-22
18. Morgan KT Nasal dosimetry, lesion distribution, and the toxicologic pathologist: a brief review Inhal Toxicol 1994 6 suppl 41 57
19. Morgan KT, Kimbell JS, Monticello TM, Patra AL, Fleishman A Studies of inspiratory airflow patterns in the nasal passages of the F-344 rat and rhesus monkey using nasal molds: relevance to formaldehyde toxicity Toxicol Appl Pharmacol 1991 110 223-40
20. Morgan KT, Jiang XZ, Starr TB, Kerns WD More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas Toxicol Appl Pharmacol 1986 82 264-71
21. Morgan KT, Monticello TM Airflow, gas deposition, and lesion distribution in the nasal passages Environ Health Perspect 1990 85 209-18
22. Moulin FJ, Brenneman KA, Kimbell JS, Dorman DC, James RA Correlation of regional hydrogen sulfide flux prediction with the distribution of nasal olfactory lesions in subchronically exposed rats Toxicol Sci 2000 54 1-S 312-13
23. Schlosser PM, Lilly PD, Conolly RB, Janszen DB, Kimbell JS Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment DNA-protein cross-link dosimetry model to estimate human equivalent doses Risk Anal 2003 23 473-87
24. Segal RA, Kepler GM, Kimbell JS Correlation of nasal surface-area-to-volume ratio with predicted inhaled gas uptake efficiency in humans Toxicol Sci 2004 in press
25. Subramaniam RP, Richardson RB, Morgan KT, Guilmette RA, Kimbell JS Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx Inhal Toxicol 1998 10 91 120
26. Wexler D, Kimbell J Aerodynamic effects of inferior turbinate reduction: computational fluid dynamics simulation J Laryngol Otol Suppl 2003 2003 Jul 29 74
27. Wolf DC, Morgan KT, Gross EA, Barrow C, Moss OR, James A, Popp JA Two-year inhalation exposure of female and male B6C3F1 mice and F344 rats to chlorine gas induces lesions confined to the nose Fundam Appl Toxicol 1995 24 111-31