Propranolol blocks cocaine-induced cerebral vasodilation in newborn sheep

Critical Care Medicine

Volumn 27, Issue 4, 1999, Pages 784-789

  O'Brien, Thomas P ^a   Pane, Maria A ^a   Traystman, Richard J ^a   Gleason, Christine A ^b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

adrenergic blockade; Cerebrovascular; Cocaine; Developing brain; Drug abuse; Neurobiology; Physiology; Vasodilation

Indexed keywords

ADRENALIN; BENZOYLECGONINE; BETA ADRENERGIC RECEPTOR; COCAINE; ECGONINE METHYL ESTER; NORADRENALIN; PROPRANOLOL;

ADRENALIN BLOOD LEVEL; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTERY DILATATION; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN DEVELOPMENT; BRAIN VASCULAR RESISTANCE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SHEEP; VENOUS OXYGEN TENSION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; COCAINE-RELATED DISORDERS; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; INJECTIONS, INTRAVENOUS; MALE; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA; SHEEP; VASCULAR RESISTANCE;

EID: 0032946373     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199904000-00036     Document Type: Article

References (36)

1. Bandstra ES, Burkette G: Maternal-fetal and neonatal effects of in utero cocaine exposure. Semin Perinatol 1991; 15:288-301
2. Singer L, Arendt R, Minnes S: Neurodevelopmental effects of cocaine. Clin Perinatol 1993; 20:245-262
3. Volpe JJ: Effects of cocaine use on the fetus. N Engl J Med 1992; 327: 399-407
4. Dohi S, Jones MD Jr, Hudak ML, et al: Effects of cocaine on pial arterioles in cats. Stroke 1990; 21:1710-1714
5. Gleason CA, Iida H, O'Brien TP, et al: Fetal responses to acute maternal cocaine injection in sheep. Am J Physiol 1993; 265:H9-H14
6. Iida H, Gleason CA, O'Brien TP, et al: Fetal responses to acute fetal cocaine injection in sheep. Am J Physiol 1994; 267:H1968-H1975
7. O'Brien TP, Gleason CA, Jones MD Jr, et al: Cerebral responses to single and multiple cocaine injections in newborn sheep. Pediatr Res 1994; 35:339-343
8. Kurth CD, Monitto ML, Albuquerque MLC, et al: Cocaine and its metabolites constrict cerebral arterioles in newborn pigs. J Pharmacol Exp Ther 1993; 265:587-591
9. Madden JA, Powers RH: Effect of cocaine and cocaine metabolites on cerebral arteries in vitro. Life Sci 1990; 47:1109-1114
10. Albuquerque ML, Kurth CD: Cocaine constricts immature cerebral arterioles by a local anesthetic mechanism. Eur J Pharmacol 1993; 249:215-220
11. Covert RF, Schreiber MD, Tebbert IR, et al: Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecgonine in conscious and anesthetized fetal lambs. J Pharmacol Exp Ther 1994; 270:118-126
12. Schreiber MD, Madden JA, Covert RF: Effects of cocaine, benzoylecogonine, and cocaine metabolites on cannulated pressurized fetal sheep cerebral arteries. J Appl Physiol 1994; 77:834-839
13. Catravas JD, Waters IW: Acute cocaine intoxication in the conscious dog: Studies on the mechanism of lethality. J Pharmacol Exp Ther 1981; 217: 350-356
14. Guinn MM, Bedford JA, Wilson MC: Antagonism of intravenous cocaine lethality in nonhuman primates. Clin Toxicol 1980; 16:499-508
15. Heymann MA, Payne BD, Hoffman JIE, et al: Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 1977; 20:55-77
16. Cone EJ, Hillsgrove M, Darwin MD: Simultaneous measurement of cocaine, cocaethylene, their metabolites and "crack" pyrolysis products by gas chromatography-mass spectrometry. Clin Chem 1994; 40:1299-1305
17. Nishijima JK, Breslow MJ, Raff H, et al: Regional adrenal blood flow during hypoxia in anesthetized, ventilated dogs. Am J Physiol 1989; 256:H94-H100
18. Nyhan DP, Goll HM, Chen BB, et al: Pentobarbital anesthesia alters pulmonary vascular response to neural antagonists. Am J Physiol 1989; 256: H1384-H1392
19. Gay G: Clinical management of acute and chronic cocaine poisoning. Ann Emerg Med 1982; 11:562-572
20. Rappolt RT, Gay G, Inaba DS: Propranolol: A specific antagonist to cocaine. Clin Toxicol 1977; 10:265-271
21. Rappolt RT, Gay G, Inaba DS: Use of Inderal in I-a and I-b classification of cocaine and other sympathomometric reactions. Clin Toxicol 1978; 13: 325-332
22. Ramoska E, Sacchetti AD: Propranolol-induced hypertension in treatment of cocaine intoxication. Ann Emerg Med 1985; 14:1112-1113
23. Lange RA, Cigarro RG, Flores ED, et al: Potentiation of cocaine-induced coronary vasocontriction by beta-adrenergic blockade. Ann Intern Med 1990; 112:897-903
24. 50 cocaine insult in a chronically instrumented rat model: Are beta-blockers contraindicated? Ann Emerg Med 1991; 20:768-777
25. Derlet RW, Albertson TE, Rice P: Antagonism of cocaine, amphetamine and methamphetamine toxicity. Pharmacol Biochem Behav 1990; 36:745-749
26. Suzuki N, Gomi Y, Ingaki O, et al: Propranolol blocks cocaine-induced potentiation of the contraction in the smooth muscle of the rat vas deferens. J Pharmacol 1990; 13:172-178
27. Pane MA, Gleason CA, Traystman RJ: Ecgonine methyl ester, a major cocaine metabolite, causes cerebral vasodilation in neonatal sheep. Pediatr Res 1997; 41:815-821
28. Edvinsson L, Owman C: Pharmacological characterization of adrenergic alpha and beta receptors mediating the vasomotor responses of cerebral arteries in vitro. Circ Res 1974; 35:835-849
29. Tsukahara T, Taniguchi T, Shuimohama S, et al: Characterization of beta adrenergic receptors in human cerebral arteries and alteration of the receptors after subarachnoid hemorrhage. Stroke 1986; 17:202-207
30. Edvinsson L: Neurogenic mechanisms in the cerebrovascular bed: Autonomic nerves, amine receptors and their effect on cerebral blood flow. Acta Physiol Scand 1975; 96(Supp 427):1-35
31. Pitts DK, Udom CE, Marwah J: Neuropharmacology of cocaine: Role of monoaminergic systems. Monogr Neural Sci 1987; 13:34-54
32. Winquist RJ, Webb RC, Bohr DF: Relaxation to transmural nerve stimulation and exogenously added NE in porcine cerebral vessels. Circ Res 1992; 51:769-776
33. Harder DR, Abel PW, Hermsmeyer K: Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine. Circ Res 1981; 49:1237-1242
34. MacKenzie ET, McColloch J, Harper AM: Influences of endogenous norepinephrine on cerebral blood flow and metabolism. Am J Physiol 1976; 231:489-493
35. Meyer JJ, Okamoto S, Shimazu K, et al: Cerebral metabolic changes during treatment of subacute cerebral infarction by alpha and beta adrenergic blockade with phenoxybenzamine and propranolol. Stroke 1974; 5:180-195
36. Javaid JI, Fischman MW, Schuster CR, et al: Cocaine plasma concentration: relation to physiological and subjective effects in humans. Science 1978; 202:227-228