The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase

Brain Research

Volumn 1089, Issue 1, 2006, Pages 1-9

  Akasaka, Soichiro ^a   Nomura, Masayoshi ^a   Nishii, Hisae ^a   Fujimoto, Naohiro ^a   Ueta, Yoichi ^a   Tsutsui, Masato ^a   Shimokawa, Hiroaki ^b   Yanagihara, Nobuyuki ^a   Matsumoto, Tetsuro ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Adrenocorticotropic hormone; Corticotropin releasing hormone; In situ hybridization histochemistry; Inducible nitric oxide synthase; Knockout mice; Lipopolysaccharide; Nitric oxide

Indexed keywords

BIOLOGICAL MARKER; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROTEIN C FOS;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; GENE INDUCTION; GENETIC TRANSCRIPTION; GENOTYPE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; THALAMUS MIDLINE NUCLEUS; UPREGULATION;

ADRENOCORTICOTROPIC HORMONE; AMYGDALA; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; GENE EXPRESSION REGULATION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RNA, MESSENGER; SHOCK, SEPTIC; UP-REGULATION;

EID: 33646771818     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.02.112     Document Type: Article

References (52)

1. Beishuizen A., and Thijs L.G. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J. Endotoxin. Res. 9 (2003) 3-24
2. Breder C.D., Hazuka C., Ghayur T., Klug C., Huginin M., Yasuda K., Teng M., and Saper C.B. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 11393-11397
3. Bredt D.S., Hwang P.M., Glatt C.E., Lowenstein C., Reed R.R., and Snyder S.H. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351 (1991) 714-718
4. Bugajski J., Gadek-Michalska A., Glod R., Borycz J., and Bugajski A.J. Blockade of nitric oxide formation impairs adrenergic-induced ACTH and corticosterone secretion. J. Physiol. Pharmacol. 50 (1999) 327-334
5. Bugajski J., Gadek-Michalska A., Glod R., and Bugajski A.J. Effect of social stress on COX-1 and COX-2-induced alterations in the adrenergic agonists-evoked hypothalamic-pituitary-adrenal responses. J. Physiol. Pharmacol. 52 (2001) 811-822
6. Bugajski J., Gadek-Michalska A., and Bugajski A.J. Involvement of prostaglandins in the nicotine-induced pituitary-adrenocortical response during social stress. J. Physiol. Pharmacol. 53 (2002) 847-857
7. Bugajski J., Gadek-Michalska A., and Bugajski A.J. Effect of cyclooxygenase inhibitors on the CRH-induced pituitary-adrenocortical activity during crowding stress. J. Physiol. Pharmacol. 54 (2003) 99-108
8. Costa A., Trainer P., Besser M., and Grossman A. Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res. 605 (1993) 187-192
9. Dinarello C.A., Cannon J.G., Mancilla J., Bishai I., Lees J., and Coceani F. Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res. 562 (1991) 199-206
10. Emeric-Sauval E. Corticotropin-releasing factor (CRF)-A review. Psychoneuroendocrinology 11 (1986) 277-294
11. Franklin K.B.J., and Paxinos G. The Mouse Brain Stereotaxic Coordinates (1997), Academic Press, Toronto
12. Funakoshi H., Kubota T., Kawamura N., Machida Y., Feldman A.M., Tsutsui H., Shimokawa H., and Takeshita A. Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy. Circ. Res. 90 (2002) 959-965
13. Gadek-Michalska A., and Bugajski J. Role of nitric oxide in the nicotine-induced pituitary-adrenocortical response. J. Physiol. Pharmacol. 55 (2004) 443-455
14. Harada S., Imaki T., Chikada N., Naruse M., and Demura H. Distinct distribution and time-course changes in neuronal nitric oxide synthase and inducible NOS in the paraventricular nucleus following lipopolysaccharide injection. Brain Res. 821 (1999) 322-332
15. Hoffman G.E., Smith M.S., and Verbalis J.G. c-fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front. Neuroendocrinol. 14 (1993) 173-213
16. Holzmann A. Nitric oxide and sepsis. Respir. Care Clin. N. Am. 3 (1997) 537-550
17. Kim C.K., and Rivier C.L. Nitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats. Endocrinology 141 (2000) 2244-2253
18. Kobayashi H., Hataishi R., Mitsufuji H., Tanaka M., Jacobson M., Tomita T., Zapol W.M., and Jones R.C. Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am. J. Respir. Cell Mol. Biol. 24 (2001) 390-397
19. Laflamme N., Barden N., and Rivest S. Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid. J. Mol. Neurosci. 8 (1997) 165-179
20. Lamas S., Marsden P.A., Li G.K., Tempst P., and Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 6348-6352
21. Lee S., Kim C.K., and Rivier C. Nitric oxide stimulates ACTH secretion and the transcription of the genes encoding for NGFI-B, corticotropin-releasing factor, corticotropin-releasing factor receptor type 1, and vasopressin in the hypothalamus of the intact rat. J. Neurosci. 19 (1999) 7640-7647
22. Lenczowski M.J., Van Dam A.M., Poole S., Larrick J.W., and Tilders F.J. Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS. Am. J. Physiol. 273 (1997) R1870-R1877
23. Lyons C.R., Orloff G.J., and Cunningham J.M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267 (1992) 6370-6374
24. MacMicking J.D., Nathan C., Hom G., Chartrain N., Fletcher D.S., Trumbauer M., Stevens K., Xie Q.W., Sokol K., and Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81 (1995) 641-650
25. Makino S., Shibasaki T., Yamauchi N., Nishioka T., Mimoto T., Wakabayashi I., Gold P.W., and Hashimoto K. Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat. Brain Res. 850 (1999) 136-143
26. McCann S.M., Kimura M., Karanth S., Yu W.H., and Rettori V. Nitric oxide controls the hypothalamic-pituitary response to cytokines. Neuroimmunomodulation 4 (1997) 98-106
27. Moller C., Wiklund L., Sommer W., Thorsell A., and Heilig M. Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res. 760 (1997) 94-101
28. Nappi R.E., Bonneau M.J., and Rivest S. Influence of the estrous cycle on c-fos and CRH gene transcription in the brain of endotoxin-challenged female rats. Neuroendocrinology 65 (1997) 29-46
29. Nathan C., and Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 78 (1994) 915-918
30. Nomura M., Ueta Y., Larsen P.J., Hannibal J., Serino R., Kabashima N., Shibuya I., and Yamashita H. Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ. Endocrinology 138 (1997) 4096-4100
31. Nomura M., Saito J., Ueta Y., Muglia L.J., Pfaff D.W., and Ogawa S. Enhanced up-regulation of corticotropin-releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice. J. Neuroendocrinol. 15 (2003) 1054-1061
32. Parsadaniantz S.M., Lebeau A., Duval P., Grimaldi B., Terlain B., and Kerdelhue B. Effects of the inhibition of cyclo-oxygenase 1 or 2 or 5-lipoxygenase on the activation of the hypothalamic-pituitary-adrenal axis induced by interleukin-1beta in the male Rat. J. Neuroendocrinol. 12 (2000) 766-773
33. Pozzoli G., Tringali G., Dello Russo C., Vairano M., Preziosi P., and Navarra P. HIV-1 Gp120 protein modulates corticotropin releasing factor synthesis and release via the stimulation of its mRNA from the rat hypothalamus in vitro: involvement of inducible nitric oxide synthase. J. Neuroimmunol. 118 (2001) 268-276
34. Prewitt C.M., and Herman J.P. Lesion of the central nucleus of the amygdala decreases basal CRH mRNA expression and stress-induced ACTH release. Ann. N. Y. Acad. Sci. 746 (1994) 438-440
35. Quan N., Whiteside M., and Herkenham M. Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res. 802 (1998) 189-197
36. Quan N., Whiteside M., and Herkenham M. Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide. Neuroscience 83 (1998) 281-293
37. Rees D.D. Role of nitric oxide in the vascular dysfunction of septic shock. Biochem. Soc. Trans. 23 (1995) 1025-1029
38. Rivier C. Blockade of nitric oxide formation augments adrenocorticotropin released by blood-borne interleukin-1 beta: role of vasopressin, prostaglandins, and alpha 1-adrenergic receptors. Endocrinology 136 (1995) 3597-3603
39. Rivier C. Role of nitric oxide and carbon monoxide in modulating the ACTH response to immune and nonimmune signals. Neuroimmunomodulation 5 (1998) 203-213
40. Rivier C., and Shen G.H. In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin. J. Neurosci. 14 (1994) 1985-1993
41. Roozendaal B., Koolhaas J.M., and Bohus B. Central amygdala lesions affect behavioral and autonomic balance during stress in rats. Physiol. Behav. 50 (1991) 777-781
42. Sandi C., and Guaza C. Evidence for a role of nitric oxide in the corticotropin-releasing factor release induced by interleukin-1 beta. Eur. J. Pharmacol. 274 (1995) 17-23
43. Seo D.O., and Rivier C. Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary-adrenal axis. J. Neuroendocrinol. 13 (2001) 925-933
44. Seo D.O., Lee S., and Rivier C.C. Comparison between the influence of the intravenous and intracerebroventricular injection of a nitric oxide donor on adrenocorticotropic hormone release and hypothalamic neuronal activity. J. Neuroendocrinol. 14 (2002) 568-573
45. Singh A.K., and Jiang Y. How does peripheral lipopolysaccharide induce gene expression in the brain of rats?. Toxicology 201 (2004) 197-207
46. Stern J.E. Nitric oxide and homeostatic control: an intercellular signalling molecule contributing to autonomic and neuroendocrine integration?. Prog. Biophys. Mol. Biol. 84 (2004) 197-215
47. Steiner H., and Gerfen C.R. Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum. J. Comp. Neurol. 353 (1995) 200-212
48. Tsuchiya T., Kishimoto J., Koyama J., and Ozawa T. Modulatory effect of l-NAME, a specific nitric oxide synthase (NOS) inhibitor, on stress-induced changes in plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats: physiological significance of stress-induced NOS activation in hypothalamic-pituitary-adrenal axis. Brain Res. 776 (1997) 68-74
49. Uribe R.M., Lee S., and Rivier C. Endotoxin stimulates nitric oxide production in the paraventricular nucleus of the hypothalamus through nitric oxide synthase I: correlation with hypothalamic-pituitary-adrenal axis activation. Endocrinology 140 (1999) 5971-5981
50. Vallieres L., and Rivest S. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. J. Neurochem. 69 (1997) 1668-1683
51. Weidenfeld J., Feldman S., DeKeyser F.G., and Ovadia H. Effect of exogenous nitric oxide and inhibitors of nitric oxide synthase on the hypothalamic pituitary adrenal axis responses to neural stimuli. Neuroendocrinology 70 (1999) 153-159
52. Xie Q.W., Cho H.J., Calaycay J., Mumford R.A., Swiderek K.M., Lee T.D., Ding A., Troso T., and Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256 (1992) 225-228