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Volumn 13, Issue 3, 2006, Pages 119-123

New insights into carrier binding and epithelial uptake of the erythropoietic nutrients cobalamin and folate

Author keywords

Cobalamin binding proteins and receptors; Folate binding proteins and receptors; Megaloblastic anemia

Indexed keywords

AMNIONLESS PROTEIN; CARRIER PROTEIN; CELL RECEPTOR; COBALAMIN; COBALAMIN RECEPTOR; CUBULIN; FOLATE RECEPTOR; FOLIC ACID; GENE PRODUCT; HAPTOCORRIN; INTRINSIC FACTOR; MEGALIN; TRANSCOBALAMIN; UNCLASSIFIED DRUG; VITAMIN RECEPTOR;

EID: 33646770366     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/01.moh.0000219654.65538.5b     Document Type: Review
Times cited : (44)

References (43)
  • 1
    • 0021778323 scopus 로고
    • Vitamin B12-folate interrelationships
    • Shane B, Stokstad ELR. Vitamin B12-folate interrelationships. Annu Rev Nutr 1985; 5:115-141.
    • (1985) Annu Rev Nutr , vol.5 , pp. 115-141
    • Shane, B.1    Stokstad, E.L.R.2
  • 2
    • 3142674792 scopus 로고    scopus 로고
    • New insights into erythropoiesis: The roles of folate, vitamin B12, and iron
    • Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr 2004; 24:105-131.
    • (2004) Annu Rev Nutr , vol.24 , pp. 105-131
    • Koury, M.J.1    Ponka, P.2
  • 3
    • 0032589204 scopus 로고    scopus 로고
    • Folate and vitamin B-12
    • Scott JM. Folate and vitamin B-12. Proc Nutr Soc 1999; 58:441-448.
    • (1999) Proc Nutr Soc , vol.58 , pp. 441-448
    • Scott, J.M.1
  • 4
    • 0000236060 scopus 로고
    • Interrelations of vitamin B12 and folio acid metabolism: Folic acid clearance studies
    • Herbert V, Zalusky R. Interrelations of vitamin B12 and folio acid metabolism: folic acid clearance studies. J Clin Invest 1962; 41:1263-1276.
    • (1962) J Clin Invest , vol.41 , pp. 1263-1276
    • Herbert, V.1    Zalusky, R.2
  • 5
    • 0006986763 scopus 로고    scopus 로고
    • Intrinsic factor, haptocorrin and their receptor
    • Banerjee R, editor. New York: John Wiley & Sons
    • Alpers DH, Russel-Jones GJ. Intrinsic factor, haptocorrin and their receptor. In: Banerjee R, editor. Chemistry and biochemistry of B12. New York: John Wiley & Sons; 1999. pp. 411-440.
    • (1999) Chemistry and Biochemistry of B12 , pp. 411-440
    • Alpers, D.H.1    Russel-Jones, G.J.2
  • 6
    • 0032570583 scopus 로고    scopus 로고
    • The intrinsic factor vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
    • Moestrup SK, Kozyraki R, Kristiansen M, et al. The intrinsic factor vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 1998; 273:5235-5242.
    • (1998) J Biol Chem , vol.273 , pp. 5235-5242
    • Moestrup, S.K.1    Kozyraki, R.2    Kristiansen, M.3
  • 7
    • 12344302107 scopus 로고    scopus 로고
    • The binding properties of the human receptor for the cellular uptake of vitamin B12
    • Quadros EV, Nakayama Y, Sequeira JM. The binding properties of the human receptor for the cellular uptake of vitamin B12. Biochem Biophys Res Commun 2005; 327:1006-1010.
    • (2005) Biochem Biophys Res Commun , vol.327 , pp. 1006-1010
    • Quadros, E.V.1    Nakayama, Y.2    Sequeira, J.M.3
  • 8
    • 0029739998 scopus 로고    scopus 로고
    • Megalin-mediated endocytosis of transcobalamin-vitamin-B-12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
    • USA
    • Moestrup SK, Birn H, Fischer PB, et al. Megalin-mediated endocytosis of transcobalamin-vitamin-B-12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Proc Natl Acad Sci USA 1996; 93:8612-8617.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 8612-8617
    • Moestrup, S.K.1    Birn, H.2    Fischer, P.B.3
  • 9
    • 0036080704 scopus 로고    scopus 로고
    • Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B12
    • Birn H, Willnow TE, Nielsen R, et al. Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B12. Am J Physiol Renal Physiol 2002; 282:F408-F416.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Birn, H.1    Willnow, T.E.2    Nielsen, R.3
  • 10
    • 0343773228 scopus 로고    scopus 로고
    • Transcellular transport of vitamin B12 in LLC-PK1 renal proximal tubule cells
    • Nielsen R, Sorensen BS, Birn H, et al. Transcellular transport of vitamin B12 in LLC-PK1 renal proximal tubule cells. J Am Soc Nephrol 2001; 12:1099-1106.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1099-1106
    • Nielsen, R.1    Sorensen, B.S.2    Birn, H.3
  • 11
    • 31844440194 scopus 로고    scopus 로고
    • Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency
    • Miller JW, Garrod MG, Rockwood AL, et al. Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency. Clin Chem 2006; 52:278-285. A recent update on the use of holotranscobalamin as a plasma marker of cobalamin deficiency.
    • (2006) Clin Chem , vol.52 , pp. 278-285
    • Miller, J.W.1    Garrod, M.G.2    Rockwood, A.L.3
  • 12
    • 29744454316 scopus 로고    scopus 로고
    • Holotranscobalamin and total transcobalamin in human plasma: Determination, determinants, and reference values in healthy adults
    • Refsum H, Johnston C, Guttormsen AB, Nexo E. Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults. Clin Chem 2006; 52:129-137. A recent update on the use of holotranscobalamin as a plasma marker of cobalamin deficiency.
    • (2006) Clin Chem , vol.52 , pp. 129-137
    • Refsum, H.1    Johnston, C.2    Guttormsen, A.B.3    Nexo, E.4
  • 13
    • 0028769662 scopus 로고
    • How a protein binds B12: A 3.0 a X-ray structure of B12-binding domains of methionine synthase
    • Drennan CL, Huang S, Drummond JT, et al. How a protein binds B12: a 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science 1994; 266:1669-1674.
    • (1994) Science , vol.266 , pp. 1669-1674
    • Drennan, C.L.1    Huang, S.2    Drummond, J.T.3
  • 14
    • 0030584657 scopus 로고    scopus 로고
    • How coenzyme B-12 radicals are generated: The crystal structure of methylmalonyl-coenzyme A mutase at 2 angstrom resolution
    • Mancia F, Keep NH, Nakagawa A, et al. How coenzyme B-12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 angstrom resolution. Structure 1996; 4:339-350.
    • (1996) Structure , vol.4 , pp. 339-350
    • Mancia, F.1    Keep, N.H.2    Nakagawa, A.3
  • 15
    • 23744491246 scopus 로고    scopus 로고
    • Mapping the functional domains of human transcobalamin using monoclonal antibodies
    • Fedosov SN, Orning L, Lovli T, et al. Mapping the functional domains of human transcobalamin using monoclonal antibodies. FEBS J 2005; 272:3887-3898.
    • (2005) FEBS J , vol.272 , pp. 3887-3898
    • Fedosov, S.N.1    Orning, L.2    Lovli, T.3
  • 16
    • 14744279609 scopus 로고    scopus 로고
    • Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor
    • Fedosov SN, Fedosova NU, Berglund L, et al. Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor. Biochemistry 2005; 44:3604-3614. This study shows that the cobalamin-mediated assembly of the two intrinsic factor domains (described in this paper) is essential for high-affinity binding to cubilin.
    • (2005) Biochemistry , vol.44 , pp. 3604-3614
    • Fedosov, S.N.1    Fedosova, N.U.2    Berglund, L.3
  • 17
    • 9944256488 scopus 로고    scopus 로고
    • Assembly of the intrinsic factor domains and oligomerization of the protein in the presence of cobalamin
    • Fedosov SN, Fedosova NU, Berglund L, et al. Assembly of the intrinsic factor domains and oligomerization of the protein in the presence of cobalamin. Biochemistry 2004; 43:15095-15102.
    • (2004) Biochemistry , vol.43 , pp. 15095-15102
    • Fedosov, S.N.1    Fedosova, N.U.2    Berglund, L.3
  • 18
    • 23744450398 scopus 로고    scopus 로고
    • Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo
    • He QC, Madsen M, Kilkenney A, et al. Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo. Blood 2005; 106:1447-1453. This study demonstrates that a deletion in the amnionlesss gene accounts for Imerslund-Gräsbeck disease in dogs. This is the final elucidation of the genetic defect in the animal model, which has so far been the most informative animal model of the disease.
    • (2005) Blood , vol.106 , pp. 1447-1453
    • He, Q.C.1    Madsen, M.2    Kilkenney, A.3
  • 19
    • 11144354849 scopus 로고    scopus 로고
    • Genetically heterogeneous selective intestinal malabsorption of vitamin B12: Founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East
    • Tanner SM, Li ZY, Bisson R, et al. Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East. Hum Mutat 2004; 23:327-333.
    • (2004) Hum Mutat , vol.23 , pp. 327-333
    • Tanner, S.M.1    Li, Z.Y.2    Bisson, R.3
  • 20
    • 0033051889 scopus 로고    scopus 로고
    • Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1
    • Aminoff M, Carter JE, Chadwick RB, et al. Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1. Nat Genet 1999; 21:309-313.
    • (1999) Nat Genet , vol.21 , pp. 309-313
    • Aminoff, M.1    Carter, J.E.2    Chadwick, R.B.3
  • 21
    • 0034661941 scopus 로고    scopus 로고
    • Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B12 by cubilin
    • Kristiansen M, Aminoff M, Jacobsen C, et al. Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B12 by cubilin. Blood 2000; 96:405-409.
    • (2000) Blood , vol.96 , pp. 405-409
    • Kristiansen, M.1    Aminoff, M.2    Jacobsen, C.3
  • 22
    • 0037371866 scopus 로고    scopus 로고
    • Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
    • Tanner SM, Aminoff M, Wright FA, et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Nat Genet 2003; 33:426-429.
    • (2003) Nat Genet , vol.33 , pp. 426-429
    • Tanner, S.M.1    Aminoff, M.2    Wright, F.A.3
  • 23
    • 20144372885 scopus 로고    scopus 로고
    • Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene
    • USA
    • Tanner SM, Li ZY, Perko JD, et al. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Proc Natl Acad Sci USA 2005; 102:4130-4133. This study identifies the intrinsic factor gene as the 'unknown' third disease of Imerslund-Gräsbeck disease.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 4130-4133
    • Tanner, S.M.1    Li, Z.Y.2    Perko, J.D.3
  • 24
    • 1442357042 scopus 로고    scopus 로고
    • The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
    • Fyfe JC, Madsen M, Hojrup P, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 2004; 103:1573-1579.
    • (2004) Blood , vol.103 , pp. 1573-1579
    • Fyfe, J.C.1    Madsen, M.2    Hojrup, P.3
  • 25
    • 7244251718 scopus 로고    scopus 로고
    • Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules
    • Strope S, Rivi R, Metzger T, et al. Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules. Development 2004; 131:4787-4795.
    • (2004) Development , vol.131 , pp. 4787-4795
    • Strope, S.1    Rivi, R.2    Metzger, T.3
  • 26
    • 28444465484 scopus 로고    scopus 로고
    • Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex
    • Coudroy G, Gburek J, Kozyraki R, et al. Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex. J Am Soc Nephrol 2005; 16:2330-2337. The coordinated function of amnionless and cubilin is demonstrated in polarized cells and structural elements for the amnionless-cubilin association and for targeting the receptor complex to the apical membrane are identified.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2330-2337
    • Coudroy, G.1    Gburek, J.2    Kozyraki, R.3
  • 27
    • 0034073250 scopus 로고    scopus 로고
    • Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
    • Birn H, Fyfe JC, Jacobsen C, et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000; 105:1353-1361.
    • (2000) J Clin Invest , vol.105 , pp. 1353-1361
    • Birn, H.1    Fyfe, J.C.2    Jacobsen, C.3
  • 28
    • 0033056072 scopus 로고    scopus 로고
    • The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    • Kozyraki R, Fyfe J, Kristiansen M, et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 1999; 5:656-661.
    • (1999) Nat Med , vol.5 , pp. 656-661
    • Kozyraki, R.1    Fyfe, J.2    Kristiansen, M.3
  • 29
    • 0035940434 scopus 로고    scopus 로고
    • Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
    • USA
    • Kozyraki R, Fyfe J, Verroust PJ, et al. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci USA 2001; 98:12491-12496.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 12491-12496
    • Kozyraki, R.1    Fyfe, J.2    Verroust, P.J.3
  • 30
    • 0035065591 scopus 로고    scopus 로고
    • The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain
    • Kalantry S, Manning S, Haub O, et al. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. Nat Genet 2001; 27:412-416.
    • (2001) Nat Genet , vol.27 , pp. 412-416
    • Kalantry, S.1    Manning, S.2    Haub, O.3
  • 31
    • 0023948431 scopus 로고
    • Characterization of a 280-Kd protein restricted to the coated pits of the renal brush-border and the epithelial-cells of the yolk-sac: Teratogenic effect of the specific monoclonal-antibodies
    • Sahali D, Mulliez N, Chatelet F, et al. Characterization of a 280-Kd protein restricted to the coated pits of the renal brush-border and the epithelial-cells of the yolk-sac: teratogenic effect of the specific monoclonal-antibodies. J Exp Med 1988; 167:213-218.
    • (1988) J Exp Med , vol.167 , pp. 213-218
    • Sahali, D.1    Mulliez, N.2    Chatelet, F.3
  • 32
    • 0041305877 scopus 로고    scopus 로고
    • Membrane transport of folates
    • Matherly LH, Goldman D. Membrane transport of folates. Vitam Horm 2003;66:403-456.
    • (2003) Vitam Horm , vol.66 , pp. 403-456
    • Matherly, L.H.1    Goldman, D.2
  • 33
    • 1942439040 scopus 로고    scopus 로고
    • Folate receptor endocytosis and trafficking
    • Sabharanjak S, Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 2004; 56:1099-1109.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1099-1109
    • Sabharanjak, S.1    Mayor, S.2
  • 34
    • 0032884078 scopus 로고    scopus 로고
    • Mice lacking the folic acid-binding protein Folbpl are defective in early embryonic development
    • Piedrahita JA, Oetama B, Bennett GD, et al. Mice lacking the folic acid-binding protein Folbpl are defective in early embryonic development. Nat Genet 1999; 23:228-232.
    • (1999) Nat Genet , vol.23 , pp. 228-232
    • Piedrahita, J.A.1    Oetama, B.2    Bennett, G.D.3
  • 36
    • 0347988053 scopus 로고    scopus 로고
    • Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect
    • Rothenberg SP, da Costa MP, Sequeira JM, et al. Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect. N Engl J Med 2004; 350:134-142.
    • (2004) N Engl J Med , vol.350 , pp. 134-142
    • Rothenberg, S.P.1    Da Costa, M.P.2    Sequeira, J.M.3
  • 37
    • 0026476410 scopus 로고
    • Cellular-localization of the folate receptor: Potential role in drug toxicity and folate homeostasis
    • Weitman SD, Weinberg AG, Coney LR, et al. Cellular-localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res 1992; 52:6708-6711.
    • (1992) Cancer Res , vol.52 , pp. 6708-6711
    • Weitman, S.D.1    Weinberg, A.G.2    Coney, L.R.3
  • 38
    • 20544452110 scopus 로고    scopus 로고
    • Renal tubular reabsorption of folate mediated by folate binding protein 1
    • Birn H, Spiegelstein O, Christensen El, Finnell RH. Renal tubular reabsorption of folate mediated by folate binding protein 1. J Am Soc Nephrol 2005; 16:608-615. The first in-vivo study showing that the folate receptor is quantitatively important for folate uptake. The study is based on studies of folate receptor-α in theb kidney.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 608-615
    • Birn, H.1    Spiegelstein, O.2    Christensen, El.3    Finnell, R.H.4
  • 39
    • 0030803726 scopus 로고    scopus 로고
    • Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule
    • Birn H, Nielsen S, Christensen EI. Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule. Am J Physiol Renal Physiol 1997; 41:F70-F78.
    • (1997) Am J Physiol Renal Physiol , vol.41
    • Birn, H.1    Nielsen, S.2    Christensen, E.I.3
  • 40
    • 0029044628 scopus 로고
    • Insolubility and redistribution of Gpi-anchored proteins at the cell-surface after detergent treatment
    • Mayor S, Maxfield FR. Insolubility and redistribution of Gpi-anchored proteins at the cell-surface after detergent treatment. Mol Biol Cell 1995; 6:929-944.
    • (1995) Mol Biol Cell , vol.6 , pp. 929-944
    • Mayor, S.1    Maxfield, F.R.2
  • 41
    • 24644481995 scopus 로고    scopus 로고
    • Megalin binds and mediates cellular internalization of folate binding protein
    • Birn H, Zhai XY, Holm J, et al. Megalin binds and mediates cellular internalization of folate binding protein. FEBS J 2005; 272:4423-4430.
    • (2005) FEBS J , vol.272 , pp. 4423-4430
    • Birn, H.1    Zhai, X.Y.2    Holm, J.3
  • 42
    • 20444491137 scopus 로고    scopus 로고
    • Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells
    • Verwei M, van den Berg H, Havenaar R, Groten JP. Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells. Eur J Nutr 2005; 44:242-249.
    • (2005) Eur J Nutr , vol.44 , pp. 242-249
    • Verwei, M.1    Van Den Berg, H.2    Havenaar, R.3    Groten, J.P.4
  • 43
    • 29444451094 scopus 로고    scopus 로고
    • Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type
    • Lerner-Ellis JP, Tirone JC, Pawelek PD, et al. Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Nat Genet 2006; 38:93-100. An important and comprehensive study showing 42 different mutations in the MMACHC gene as the genetic cause of methylmalonic aciduria and homocystinuria in 204 patients.
    • (2006) Nat Genet , vol.38 , pp. 93-100
    • Lerner-Ellis, J.P.1    Tirone, J.C.2    Pawelek, P.D.3


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