Trends in AIDS and mortality in HIV-lnfected subjects with hemophilia from 1985 to 2003: The competing risks for death between AIDS and liver disease

Journal of Acquired Immune Deficiency Syndromes

Volumn 41, Issue 5, 2006, Pages 624-631

  Del Amo, Julia ^a   Pérez Hoyos, Santiago ^b   Moreno, Alicia ^b   Quintana, Manuel ^c   Ruiz, Isabel ^d   Cisneros, José Miguel ^e   Ferreros, Inmaculada ^b   González, Cristina ^a   De Olalla, Patricia García ^f   Pérez, Rosario ^e   Hernández, Ildefonso ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b Generalitat Valenciana   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^f AGÈNCIA DE SALUT PÚBLICA DE BARCELONA   (Spain)

Author keywords

Competing risks; Hemophilia; Hepatitis C virus; Highly active antiretroviral therapy; HIV progression

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; AGED; ALL CAUSE MORTALITY; ARTICLE; BLEEDING; CAUSE OF DEATH; COMPETING RISK; DISEASE COURSE; DRUG EXPOSURE; EPIDEMIOLOGICAL DATA; FEMALE; HEMOPHILIA; HEMOPHILIA A; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERVAL CENSORED DATA; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL ANALYSIS; MORTALITY; POISSON DISTRIBUTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR; SEROCONVERSION; SPAIN; SURVIVAL; TREND STUDY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADOLESCENT; ADULT; COHORT STUDIES; DEMOGRAPHY; FEMALE; HEMOPHILIA A; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; LIVER DISEASES; MALE; POISSON DISTRIBUTION; SPAIN; TIME FACTORS;

EID: 33646768987     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qai.0000194232.85336.dc     Document Type: Article

References (34)

1. Lee CA, Phillips AN, Elford J, et al. Progression of HIV disease in a haemophilic cohort followed for 11 years and the effect of treatment. BMJ. 1991;303:1093-1096.
2. Rosenberg PS, Goedert JJ, Biggar RJ. Effect of age at seroconversion on the natural AIDS incubation distribution. Multicenter Hemophilia Cohort Study and the International Registry of Seroconverters. AIDS. 1994;8:803-810.
3. Eyster ME, Gail MH, Ballard JO, et al. Natural history of human immunodeficiency virus infections in haemophiliacs: effects of T-cell subsets, platelet counts, and age. Ann Intern Med. 1987;107:1-6.
4. Darby SC, Ewart DW, Giangrande PL, et al. Mortality before and after HIV infection in the complete UK population of haemophiliacs. UK Haemophilia Centre Directors' Organisation. Nature. 1995;377:79-82.
5. Touloumi G, Karafoulidou A, Gialeraki A, et al. Determinants of progression of HIV infection in a Greek hemophilia cohort followed for up to 16 years after seroconversion. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:89-97.
6. Collaborative Group on AIDS Incubation and HIV survival including the CASCADE EU Concerted Action. Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Lancet. 2000;355:1131-1140.
7. Sabin CA, Yee TT, Devereux H, et al. Two decades of HIV infection in a cohort of haemophilic individuals: clinical outcomes and response to highly active antiretroviral therapy. AIDS. 2000;14:1001-1007.
8. Quintana M, Del Amo J, Barrasa A, et al. Progression of HIV infection and mortality by hepatitis C infection in patients with haemophilia over 20 years. Haemophilia. 2003;9:605-612.
9. Chorba TL, Holman RC, Clarke MJ, et al. Effects of HIV infection on age and cause of death for persons with haemophilia A in the United States. Am J Hematol. 2001;66:229-240.
10. UK Haemophilia Centre Doctors' Organisation. The impact of HIV on mortality rates in the complete UK haemophilia population. AIDS. 2004;18:525-533.
11. Rosendaal FR, Varekamp I, Smit C, et al. Mortality and causes of death in Dutch haemophiliacs, 1973-86. Br J Haematol. 1989;71:71-76.
12. Prins M, Sabin CA, Lee CA, et al. Pre-AIDS mortality and its association with HIV disease progression in haemophilic men, injecting drug users and homosexual men. AIDS. 2000;14:1829-1837.
13. Diamondstone LS, Aledort LM, Goedert JJ. Multicentre Hemophilia Cohort Study. Factors predictive of death among HIV-uninfected persons with haemophilia and other congenital coagulation disorders. Haemophilia. 2002;8:660-667.
14. Ragni M, Belle S. Impact of human immunodeficiency virus infection on progression to end-stage liver disease in individuals with hemophilia and hepatitis C virus infection. J Infect Dis. 2001;183:1112-1115.
15. Darby SC, Ewart DW, Giangrande PL, et al. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation. Lancet. 1997;350:1425-1431.
16. Goedert JJ, Eyster ME, Lederman MM, et al. End-stage liver disease in persons with hemophilia and transfusion-associated infections. Blood. 2002;100:1584-1589.
17. Walker IR, Julian JA, Association of Haemophilia Clinic Directors of Canada. Causes of death in Canadians with haemophilia 1980-1995. Haemophilia. 1998;4:714-720.
18. Eyster ME, Diamondstone LS, Lien JM, et al. Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus. The Multicenter Hemophilia Cohort Study. J Acquir Immune Defic Syndr. 1993;6:602-610.
19. Darby SC, Ewart DW, Giangrande PLF, et al, for the UK Haemophilia Centre Directors' Organisation. Importance of age at infection with HIV-1 for survival and development of AIDS in UK hemophilia population. Lancet. 1996;347:1573-1579.
20. GEMES (Grupo Español Multicéntrico para el Estudio de Seroconvertores). AIDS incubation period in Spain before highly active antiretroviral therapy. Med Clin (Barc). 2000;115:681-686.
21. Altisent Roca C, Ayestaran Altuna A, Tusell Puigbert JM, et al. Progression of HIV infection in a cohort of hemophiliacs over an 11-year period. Med Clin (Barc). 1995;104:411-414.
22. Pérez-Hoyos S, Ferreros I, del Amo J, et al. Imputation of the date of HIV seroconversion in cohorts of haemophiliacs. Gac Sanit. 2003;17:474-482.
23. Ancelle-Park R. Expanded European AIDS case definition. Lancet. 1993;341:441.
24. Clayton D, Hills M. Statistical Methods in Epidemiology. Oxford: Oxford University Press, 1998.
25. CASCADE Collaboration. Changes over calendar time in the risk of specific first AIDS-defining events following HIV seroconversion, adjusting for competing risks. Int J Epidemiol. 2002;31:951-958.
26. Qurishi N, Kreuzberg C, Luchters G, et al. Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection. Lancet. 2003;362:1708-1713.
27. Klein MB, Lalonde RG, Suissa S. The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2003;33:365-372.
28. Salmon-Ceron D, Lewden C, Morlat P, et al. Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol. J Hepatol. 2005;42:799-805.
29. Soriano V, Garcia-Samaniego J, Valencia E, et al. Impact of chronic liver disease due to hepatitis viruses as cause of hospital admission and death in HIV-infected drug users. Eur J Epidemiol. 1999;15:1-4.
30. Klein MB, Lalonde RG, Suissa S. The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2003;33:365-372.
31. Lee C, Dusheiko G. The natural history and antiviral treatment of hepatitis C in haemophilia. Haemophilia. 2002;8:322-329.
32. Rumi MG, De Filippi F, Santagostino E, et al. Hepatitis C in haemophilia: lights and shadows. Haemophilia. 2004;10(Suppl 4):211-215.
33. Romero M, Perez-Olmeda M, Garcia-Samaniego J, et al. Management of chronic hepatitis C in patients co-infected with HIV: focus on safety considerations. Drug Saf. 2004;27:7-24.
34. Porter K, Johnson AM, Phillips AN, et al. The practical significance of potential biases in estimates of the AIDS incubation periods distribution in the UK Register of HIV Seroconverteres. AIDS. 1999;13:1943-1951.