Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: The Framingham study

Journal of Lipid Research

Volumn 47, Issue 5, 2006, Pages 990-996

  Elosua, Roberto ^a,b,c   Ordovas, Jose M ^a   Cupples, L Adrienne ^b,d   Lai, Chao Qiang ^a   Demissie, Serkalem ^b   Fox, Caroline S ^d,e,f   Polak, Joseph F ^e   Wolf, Philip A ^d,g   D'Agostino Sr , Ralph B ^d   O'Donnell, Christopher J ^d,f,h  

^a TUFTS UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^c INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^d FRAMINGHAM HEART STUDY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apolipoprotein A5 gene; Apolipoproteins; Carotid arteries; Epidemiology; Genetics

Indexed keywords

APOLIPOPROTEINS; APOLIPOPROTEINS A; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; CAROTID ARTERY, INTERNAL; CAROTID STENOSIS; COHORT STUDIES; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; OBESITY; PREVALENCE; VARIATION (GENETICS);

EID: 33646762457     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M500446-JLR200     Document Type: Article

References (41)

1. Pennacchio, L. A., O. Michael, J. A. Hubacek, J. C. Cohen, D. R. Cox, J. C. Fruchart, R. M. Krauss, and E. M. Rubin. 2001. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 294: 169-173.
2. Van der Vliet, H. N., M. G. Sammels, A. C. J. Leegwater, J. H. Levels, P. H. Reitsma, W. Boers, and R. A. Chamuleau. 2001. Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 276: 44512-44520.
3. Van der Vliet, H. N., F. G. Schaap, J. H. M. Levels, R. Ottenhoff, N. Looije, J. G. Wesseling, A. K. Groen, and R. A. Chamuleau. 2002. Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem. Biophys. Res. Commun. 295: 1156-1159.
4. Schaap, F. G., P. C. Rensen, P. J. Voshol, C. Vrius, H. N. van der Vliet, R. A. Chamuleau, L. M. Havekes, A. K. Groen, and K. W. van Dijk. 2004. ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein- triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis. J. Biol. Chem. 279: 27941-27947.
5. Fruchart-Najib, J., E. Bauge, L. S. Niculescu, T. Pham, B. Thomas, C. Rommens, Z. Majd, B. Brewer, L. A. Pennacchio, and J. C. Fruchart. 2004. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319: 397-404.
6. Pennacchio, L. A., M. Olivier, J. A. Hubacek, R. M. Krauss, E. M. Rubin, and J. C. Cohen. 2002. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum. Mol. Genet. 11: 3031-3038.
7. Ribalta, J., L. Figuera, J. Fernández-Ballart, E. Vilella, M. Castro, L. Masana, and J. Joven. 2002. Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia. Clin. Chem. 48: 1597-1600.
8. Nabika, T., S. Nasreen, S. Kobayashi, and J. Masuda. 2002. The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. Atherosclerosis. 165: 201-204.
9. Aouizerat, B. E., M. Kulkarni, D. Heilbron, D. Drown, S. Raskin, C. R. Pullinger, M. J. Malloy, and J. P. Kane. 2003. Genetic variants of a polymorphism in the human apoA-V gene: effect on plasma lipids. J. Lipid Res. 44: 1167-1173.
10. Baum, L., B. Tomlinson, and G. N. Thomas. 2003. APOA5-1131T> C polymorphism is associated with triglyceride levels in Chinese men. Clin. Genet. 63: 377-379.
11. Lai, C. Q., E. S. Tai, C. E. Tan, J. Cutter, S. K. Chew, Y. P. Zhu, X. Adiconis, and J. M. Ordovas. 2003. The apolipoprotein A5 locus is a strong determinant of plasma triglyceride concentration across ethnic groups in Singapore. J. Lipid Res. 44: 2365-2373.
12. Lai, C. Q., S. Demissie, L. A. Cupples, Y. Zhu, X. Adiconis, L. D. Parnell, D. Corella, and J.M. Ordovas. 2004. Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study. J. Lipid Res. 45: 2096-2105.
13. Hodoglugil, U., S. Tanyolac, D. W. Williamson, Y. Huang, and R. W. Mahley. 2006. Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks. J. Lipid Res. 47: 144-153.
14. Austin, M. A., P. J. Talmud, F. M. Farin, D. A. Nickerdson, K. L. Edwards, D. Leonetti, M. J. McNeely, H. M. Viernes, S. E. Humphries, and W. Y. Fujimoto. 2004. Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans. Biochim. Biophys. Acta. 1688: 1-9.
15. Talmud, P. J., S. Martin, M. R. Taskinen, M. H. Frick, M. S. Nieminen, Y. A. Kesaniemi, A. Pasternack, S. E. Humphries, and M. Syvanne. 2004. APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT Study. J. Lipid Res. 45: 750-756.
16. Hokanson, J. E., and M. A. Austin. 1996. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J. Cardiovasc. Risk. 3: 213-219.
17. Szalai, C., M. Keszei, J. Duba, Z. Prohaszka, G. T. Kozma, A. Csaszar, S. Balogh, Z. Almassy, G. Fust, and A. Czinner. 2004. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis. 173: 109-114.
18. Bi, N., S. K. Yan, G. P. Li, Z. N. Yin, and B. S. Chen. 2004. A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese. Mol. Genet. Metab. 83: 280-286.
19. Hubacek, J. A., Z. Skodova, W. Adamkova, V. Lanska, and R. Poledne. 2004. The influence of APOAV polymorphisms (T-1131>C and S19>W) on plasma triglyceride levels and risk of myocardial infarction. Clin. Genet. 65: 126-130.
20. Hsu, L. A., Y. L. Ko, C. J. Chang, C. F. Hu, S. Wu, M. S. Teng, C. L. Wang, W. J. Ho, Y. S. Ko, T. S. Hsu, et al. 2006. Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan. Atherosclerosis. 185: 143-149.
21. Burke, G. L., G. W. Evans, W. A. Riley, A. R. Sharrett, G. Howard, R. W. Barnes, W. Rosamond, R. S. Crow, P. M. Rautaharju, and G. Heiss. 1995. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 26: 386-391.
22. O'Leary, D. H., J. F. Polak, R. A. Kronmal, T. A. Manolio, G. L. Burke, and S. K. Wolfson, Jr. 1999. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults: Cardiovascular Health Study Collaborative Research Group. N. Engl. J. Med. 340: 14-22.
23. Wang, T. J., B. H. Nam, R. B. D'Agostino, P. A. Wolf, D. M. Lloyd-Jones, C. A. MacRae, P. W. Wilson, J. F. Polak, and C. J. O'Donnell. 2003. Carotid intima-media thickness is associated with premature parental coronary heart disease. The Framingham Heart Study. Circulation. 108: 572-576.
24. Fox, C. S., J. F. Polak, I. Chazaro, L. A. Cupples, P. A. Wolf, R. A. D'Agostino, and C. J. O'Donnell. 2003. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke. 34: 397-401.
25. Gnasso, A., C. Carallo, C. Irace, V. Spagnuolo, G. De Novara, P. L. Mattioli, and A. Pujia. 1996. Association between intima-media thickness and wall shear stress in common carotid arteries in healthy male subjects. Circulation. 94: 3257-3262.
26. Kannel, W. B., M. Feinleib, P.M. McNamara, R. J. Garrison, and W. P. Castelli. 1979. An investigation of coronary heart disease in families: the Framingham Offspring Study. Am. J. Epidemiol. 110: 281-290.
27. Polak, J. F., D. H. O'Learly, R. A. Kronmal, S. K. Wolfson, M. G. Bond, R. P. Tracy, J. M. Gardin, S. J. Kittner, T. R. Price, and P. J. Savage. 1993. Sonographic evaluation of carotid artery atherosclerosis in the elderly: relationship of disease severity to stroke and transient ischemic attack. Radiology. 188: 363-370.
28. Wang, T. J., B. H. Nam, P. W. Wilson, P. A. Wolf, D. Levy, J. F. Polak, R. B. D'Agostino, and C. J. O'Donnell. 2002. Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study. Arterioscler. Thromb. Vasc. Biol. 22: 1662-1667.
29. Schaid, D. J., C. M. Rowland, D. E. Tines, R. M. Jacobson, and G. A. Poland. 2002. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet. 70: 425-434.
30. Morris, R. W., and N. L. Kaplan. 2002. On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles. Genet. Epidemiol. 23: 221-233.
31. Talmud, P. J., J. Palmen, W. Putt, L. Lins, and S. E. Humphries. 2005. Determination of the functionality of common APOA5 polymorphisms. J. Biol. Chem. 280: 28215-28220.
32. Lai, C. Q., L. D. Parnell, and J. M. Ordovas. 2005. The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk. Curr. Opin. Lipidol. 16: 153-166.
33. Olivier, M., X. Wang, R. Cole, B. Gau, J. Kim, E. M. Rubin, and L. A. Pennacchio. 2004. Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. Genomics. 83: 912-923.
34. Talmud, P. J., E. Hawe, S. Martin, M. Olivier, G. J. Millar, E. M. Rubin, L. A. Pennacchio, and S. E. Humphries. 2002. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum. Mol. Genet. 11: 3039-3046.
35. Brown, S. A., J. D. Morrisett, E. Boerwinkle, R. Hutchinson, and W. Ratsch. 1993. The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler. Thromb. 13: 1558-1566.
36. Pallaud, C., C. Sass, F. Zannad, G. Siest, and S. Visvikis. 2001. APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort). Clin. Genet. 59: 316-324.
37. Islam, M. J., O. T. Raitakari, M. Juonala, M. Kahonen, N. Hutri-Kahonen, A. Collings, K. Aalto-Setala, K. Kontula, J. Marniemi, J. S. Viikari, et al. 2005. Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphism and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in the Young Finns Study. Atherosclerosis. 180: 79-86.
38. Elosua, R., L. A. Cupples, C. S. Fox, J. F. Polak, R. A. D'Agostino, Sr., P. A. Wolf, C. J. O'Donnell, and J. M. Ordovas. 2006. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: the Framingham Heart Study. Atherosclerosis. Epub ahead of print. January 20, 2006; doi:10.1016/j.atherosclerosis.2005.12.005.
39. Ruiz-Narvaez, E. A., Y. Yang, Y. Nakanishi, J. Kirchdorfer, and H. Campos. 2005. APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica. J. Lipid Res. 46: 2605-2613.
40. Spence, J. D., and R. A. Hegele. 2004. Noninvasive phenotypes of atherosclerosis: similar windows but different views. Stroke. 35: 649-653.
41. Stein, Y., and O. Stein. 2003. Lipoprotein lipase and atherosclerosis. Atherosclerosis. 170: 1-9.