Clonidine-ephedrine combination reduces pain on injection of propofol and blunts hemodynamic stress responses during the induction sequence

Journal of Clinical Anesthesia

Volumn 18, Issue 3, 2006, Pages 211-215

  Ishiyama, Tadahiko ^a   Kashimoto, Satoshi ^a   Oguchi, Takeshi ^a   Furuya, Atsushi ^a   Fukushima, Hisashi ^a   Kumazawa, Teruo ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Clonidine; Ephedrine; Hemodynamic change; Propofol induced pain

Indexed keywords

CLONIDINE; DIAZEPAM; EPHEDRINE; PROPOFOL;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; BEHAVIOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTIVE SURGERY; ENDOTRACHEAL INTUBATION; FEMALE; HEALTH STATUS; HEART RATE; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STRESS; UNIVERSITY HOSPITAL;

ANALGESICS; ANESTHETICS, INTRAVENOUS; CLONIDINE; EPHEDRINE; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; PAIN; PROPOFOL; PROSPECTIVE STUDIES; STRESS;

EID: 33646757907     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinane.2005.08.005     Document Type: Article

References (18)

1. Cheong M.A., Kim K.S., and Choi W.J. Ephedrine reduces the pain from propofol injection. Anesth Analg 95 (2002) 1293-1296
2. Orko R., Pouttu J., Ghignone M., and Rosenberg P.H. Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity. Acta Anaesthesiol Scand 31 (1987) 325-329
3. Batra Y.K., Indu B., and Puri G.D. Attenuation of pulse rate and blood pressure response to laryngoscopy and tracheal intubation by clonidine. Int J Clin Pharmacol 26 (1988) 360-363
4. Ghignone M., Calvillo O., and Quintin L. Anesthesia and hypertension: the effect of clonidine on perioperative hemodynamics and isoflurane requirements. Anesthesiology 67 (1987) 3-10
5. Guglielminotti J., Descraques C., Petitmaire S., Almenza L., Grenapin O., and Mantz J. Effects of premedication on dose requirements for propofol: comparison of clonidine and hydroxyzine. Br J Anaesth 80 (1998) 733-736
6. Ishiyama T., Kashimoto S., Oguchi T., Matsukawa T., and Kumazawa T. The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. Anesth Analg 96 (2003) 136-141
7. Asik I., Yörükoglu D., Gülay I., and Tulunay M. Pain on injection of propofol: comparison of metoprolol with lidocaine. Eur J Anaesthesiol 20 (2003) 487-489
8. Grauers A., Liljeroth E., and Åkeson J. Propofol infusion rate does not affect local pain on injection. Acta Anaesthesiol Scand 46 (2002) 361-363
9. Harmon D., Rozario C., and Lowe D. Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. Eur J Anaesthesiol 20 (2003) 158-161
10. Ho C.M., Tsou M.Y., Sun M.S., Chu C.C., and Lee T.Y. The optimal effective concentration of lidocaine to reduce pain on injection of propofol. J Clin Anesth 11 (1999) 296-300
11. Memis D., Turan A., Karamanlioglu B., Sut N., and Pamukcu Z. The use of magnesium sulfate to prevent pain on injection of propofol. Anesth Analg 95 (2002) 606-608
12. Yoshikawa T., Wajima Z., Ogura A., Inoue T., and Ogawa R. Orally administered clonidine significantly reduces pain during injection of propofol. Br J Anaesth 86 (2001) 874-876
13. 2c-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat. Pain 98 (2002) 27-35
14. Dambisya Y.M., Chan K., and Wong C.L. Role of adrenoceptors in the potentiation of opioid antinociception by ephedrine and phenylpropanolamine in mice. Psychopharmacology 105 (1991) 563-567
15. Sonohata M., Furue H., Katafuchi T., et al. Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording. J Physiol 555 (2004) 515-526
16. Ishiyama T., Oguchi T., and Kumazawa T. Baroreflex sensitivity and hemodynamic changes in elderly and young patients during propofol anesthesia. J Anesth 17 (2003) 65-67
17. El-Beheiry H., Kim J., Milne B., and Seegobin R. Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation. Can J Anaesth 42 (1995) 875-878
18. Michelsen I., Helbo-Hansen H.S., Køhler F., Lorenzen A.G., Rydlund E., and Bentzon M.W. Prophylactic ephedrine attenuates the hemodynamic response to propofol in elderly female patients. Anesth Analg 86 (1998) 477-481