The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia

Anesthesia and Analgesia

Volumn 96, Issue 1, 2003, Pages 136-141

  Ishiyama, Tadahiko ^a   Kashimoto, Satoshi ^a   Oguchi, Takeshi ^a   Matsukawa, Takashi ^a   Kumazawa, Teruo ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; EPHEDRINE; MIDAZOLAM; PROPOFOL;

ADULT; AGE; AGED; ANESTHESIA INDUCTION; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; FEMALE; HEART RATE; HEMODYNAMIC MONITORING; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA;

ADJUVANTS, ANESTHESIA; ADRENERGIC ALPHA-AGONISTS; ADULT; AGED; AGING; ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; BLOOD PRESSURE; CLONIDINE; DOUBLE-BLIND METHOD; EPHEDRINE; FEMALE; HEART RATE; HUMANS; MALE; MIDAZOLAM; MIDDLE AGED; OXYGEN; PREANESTHETIC MEDICATION; PROPOFOL; TACHYCARDIA;

EID: 0037221695     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200301000-00028     Document Type: Article

References (18)

1. Robinson BJ, Ebert TJ, O'Brien TJ, et al. Mechanisms whereby propofol mediates peripheral vasodilation in humans: Sympathoinhibition or direct vascular relaxation? Anesthesiology 1997;86:64-72.
2. eOs of propofol for blood pressure and EEG bispectral index in elderly and younger patients. Anesthesiology 1999;90:1517-27.
3. Hayakawa-Fujii Y, Iida H, Dohi S. Propofol anesthesia enhances pressor response to ephedrine in patients given clonidine. Anesth Analg 1999;89:37-41.
4. Sastre M, Garcia-Sevilla JA. Density of alpha-2A adrenoceptors and Gi proteins in the human brain: Ratio of high-affinity agonist sites to antagonist sites and effect of age. J Pharmacol Exp Ther 1994;269:1062-72.
5. 2 receptors. Ann N Y Acad Sci 1994;717:282-92.
6. 2noradrenergic/imidazoline receptors in suicide victims: A postmortem brain autoradiographic analysis. Eur Neuropsychopharmacol 2000;10:265-71.
7. Rossolini G, Viticchi C, Basso A, et al. Thymus-induced recovery of age-related decrease of brain cortex α- and β-adrenoceptors. Int J Neurosci 1991;59:143-50.
8. Biddle NL, Gelb AW, Hamilton JT. Propofol differentially attenuates the responses to exogenous and endogenous norepinephrine in the isolated rat femoral artery in vitro. Anesth Analg 1995;80:793-9.
9. Peacock JE, Lewis RP, Reilly CS, Nimmo WS. Effect of different rates of infusion of propofol for induction of anaesthesia in elderly patients. Br J Anaesth 1990;65:346-52.
10. Peacock JE, Spiers SP, McLauchlan GA, et al. Infusion of propofol to identify smallest effective doses for induction of anaesthesia in young and elderly patients. Br J Anaesth 1992;69:363-7.
11. 1-adrenergic receptors by vessel bed and age. Circulation 1999;100:2336-43.
12. Tanaka M, Nishikawa T. Effects of clonidine premedication on the pressor response to alpha-adrenergic agonists. Br J Anaesth 1995;75:593-7.
13. Kondo U, Kim S-O, Nakayama M, Murray PA. Pulmonary vascular effects of propofol at baseline, during elevated vasomotor tone, and in response to sympathetic α- and β-adrenoceptor activation. Anesthesiology 2001;94:815-23.
14. Yu GS, Chen MZ, Han QD. Alterations of subtypes of cardiac adrenoceptors in old rat. Zhongguo Yao Li Xue Bao 1995;16: 452-4.
15. Pan HY, Hoffman BB, Pershe RA, Blaschke TF. Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther 1986;239:802-7.
16. Xu H, Aibiki M, Yokono S, Ogli K. Dose-dependent effects of propofol on renal sympathetic nerve activity, blood pressure and heart rate in urethane-anesthetized rabbits. Eur J Pharmacol 2000;387:79-85.
17. Miller RD. Anesthesia. In: Reves JG, Glass PSA, Lubarsky DA, eds. Nonbatbiturate Intravenous Anesthetics. Philadelphia: Churchill Livingstone, 2000:228-72.
18. Schnider TW, Minto CF, Shafer SL, et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999;90:1502-16.