Glycaemic control in trauma patients, is there a role?

Trauma

Volumn 8, Issue 1, 2006, Pages 13-19

  Langouche, Lies ^a   Vanhorebeek, Ilse ^a   Van Den Berghe, Greet ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

critical illness; hyperglycaemia; insulin; organ failure; sepsis; surgery

Indexed keywords

GLUCOSE; INSULIN; LIPID;

ARTICLE; CATABOLISM; CELL FUNCTION; CLINICAL TRIAL; CRITICALLY ILL PATIENT; DATA ANALYSIS; DISEASE SEVERITY; ENDOTHELIUM; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; IMMUNOPATHOLOGY; INFLAMMATION; INJURY; INSULIN RESISTANCE; INSULIN TREATMENT; INTENSIVE CARE UNIT; LIPID BLOOD LEVEL; LIVER CELL; MITOCHONDRION; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; POPULATION RESEARCH; PROSPECTIVE STUDY; PROTECTION; STRESS; SURGICAL INJURY; SURGICAL PATIENT; SURVIVAL; ULTRASTRUCTURE;

EID: 33646730070     PISSN: 14604086     EISSN: None     Source Type: Journal    
DOI: 10.1191/1460408606ta354oa     Document Type: Article

References (46)

1. Agus MS, Javid PJ, Ryan DP, Jaksic T. 2004. Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation. J Pediatr Surg 39: 839-844.
2. Bessey PQ, Lowe KA. 1993. Early hormonal changes affect the catabolic response to trauma. Ann Surg 218: 476-489.
3. Black CT, Hennessey PJ, Andrassy RJ. 1990. Short-term hyperglycemia depresses immunity through nonenzymatic glycosylation of circulating immunoglobulin. J Trauma 30: 830-832.
4. Bochicchio GV, Sung J, Joshi M, Bochicchio K, Johnson SB, Meyer W, Scalea TM. 2005. Persistent hyper-glycemia is predictive of outcome in critically ill trauma patients. J Trauma 58: 921-924.
5. Brix-Christensen V, Andersen SK, Andersen R, Mengel A, Dyhr T, Andersen NT, Larsson A, Schmitz O, Orskov H, Tonnesen E. 2004. Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model. Anesthesiology 100: 861-870.
6. Capes SE, Hunt D, Malmberg K, Gerstein HC. 2000. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355: 773-778.
7. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. 2001. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32: 2426-2432.
8. Das UN, 2003. Insulin: an endogenous cardioprotector. Curr Opin Crit Care 9: 375-383.
9. Finney SJ, Zekveld C, Elia A, Evans TW. 2003. Glucose control and mortality in critically ill patients. JAMA 290: 2041-2047.
10. Furnary AP, Gao G, Grunkemeier GL, Wu Y, Zerr KJ, Bookin SO, Floten HS, Starr A. 2003. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 125: 1007-1021.
11. Furnary AP, Wu Y, Bookin SO. 2004. Effect of hyper-glycemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project. Endocr Pract 10(Suppl 2), 21-33.
12. Furnary AP, Zerr KJ, Grunkemeier GL, Starr A. 1999. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 67: 352-360.
13. Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai, M. 2001. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 51: 540-544.
14. Gore DC, Wolf SE, Sanford AP, Herndon DN, Wolfe RR. 2004. Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients. Am J Physiol Endocrinol. Metab 286: E529-E534.
15. Grey NJ, Perdrizet GA. 2004. Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 10(Suppl 2), 46-52.
16. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G. 2003. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 88: 1082-1088.
17. Harris HW, Grunfeld C, Feingold KR, Rapp JH. 1990. Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice. J Clin Invest 86: 696-702.
18. Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH. 1993. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest 91: 1028-1034.
19. Hillier TA, Fryburg DA, Jahn LA, Barrett EJ. 1998. Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm. Am J Physiol 274: E1067-E1074.
20. Jeremitsky E, Omert LA, Dunham CM, Wilberger J, Rodriguez A. 2005. The impact of hyperglycemia on patients with severe brain injury. J Trauma 58: 47-50.
21. Jeschke MG, Klein D, Bolder U, and Einspanier, R. (2004a). Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 145: 4084-4093.
22. Jeschke MG, Klein D, Herndon DN. (2004b). Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg 239: 553-560.
23. Klein D, Schubert T, Horch RE, Jauch KW, Jeschke MG. 2004. Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann Surg 240: 340-349.
24. A., Klip, T., Tsakiridis, A., Marette, P.A., Ortiz, Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures, FASEB J, (1994), 8, 43-53
25. Krinsley JS. 2004. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79: 992-1000.
26. Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC. 2004. Relationship of early hyper-glycemia to mortality in trauma patients. J Trauma 56: 1058-1062.
27. Langouche L, Vanhorebeek I, Vlasselaers D, Vander Perre S, Wouters PJ, Skogstrand K, Hansen TK, Van den Berghe G. 2005. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115: 2277-2286.
28. Malmberg K. 1997. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. Brit Med J 314: 1512-1515.
29. McCowen KC, Malhotra A, Bistrian BR. 2001. Stress-induced hyperglycemia. Crit Care Clin 17: 107-124.
30. Mesotten D, Delhanty PJ, Vanderhoydonc F, Hardman KV, Weekers F, Baxter RC, Van den Berghe G. 2002. Regulation of insulin-like growth factor binding protein-1 during protracted critical illness. J Clin Endocrinol Metab 87: 5516-5523.
31. Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe, G. 2004. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89: 219-226.
32. Rovlias A, Kotsou S. 2000. The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 46: 335-342.
33. Siroen MP, van Leeuwen PA, Nijveldt RJ, Teerlink T, Wouters PJ, Van den BG. 2005. Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality? Crit Care Med 33: 504-510.
34. Soop M, Duxbury H, Agwunobi AO, Gibson JM, Hopkins SJ, Childs C, Cooper RG, Maycock P, Little RA, Carlson GL. 2002. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 282: E1276-E1285.
35. Thorell A, Nygren J, Ljungqvist O. 1999. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care 2: 69-78.
36. Van den Berghe G. 2004. How does blood glucose control with insulin save lives in intensive care? J Clin Invest 114: 1187-1195.
37. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. 2005. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64: 1348-1353.
38. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. 2001. Intensive insulin therapy in critically ill patients. N Engl J Med 345: 1359-1367.
39. Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P. 2003. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 31: 359-366.
40. Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, Wolf-Peeters C, Van den Berghe G. 2005. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365: 53-59.
41. Weekers F, Giulietti AP, Michalaki M, Coopmans W, Van Herck E, Mathieu C, Van den Berghe G. 2003. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology 144: 5329-5338.
42. Wolfe RR, Durkot MJ, Allsop JR, Burke JF. 1979. Glucose metabolism in severely burned patients. Metabolism 28: 1031-1039.
43. Wolfe RR, Herndon DN, Jahoor F, Miyoshi H, Wolfe M. 1987. Effect of severe burn injury on substrate cycling by glucose and fatty acids. N Engl J Med 317: 403-408.
44. Yendamuri S, Fulda GJ, Tinkoff GH. 2003. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 55: 33-38.
45. Zerr KJ, Furnary AP, Grunkemeier GL, Bookin S, Kanhere V, Starr A. 1997. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg 63: 356-361.
46. Zhang XJ, Chinkes DL, Irtun O, Wolfe RR. 2002. Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Am J Physiol Endocrinol Metab 282: E1308-E1315.