New molecular target for modulation of aging process

Antioxidants and Redox Signaling

Volumn 8, Issue 3-4, 2006, Pages 620-627

  Park, Sang Chul ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHYSIN; CAVEOLIN 1; CAVEOLIN 2; CAVEOLIN 3; CLATHRIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; MITOGENIC AGENT; PROTEIN P53;

AGE; AGED; AGING; CAVEOLA; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; GATE THEORY OF AGING; GENE EXPRESSION REGULATION; HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; THEORY;

AGING; AMINO ACID MOTIFS; ANIMALS; CAVEOLINS; CELL AGING; ENDOCYTOSIS; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 33646705879     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.620     Document Type: Review

References (53)

1. Anderson RG. The caveolae membrane system. Annu Rev Biochem 67: 1996-2003, 1998 .
2. Anderson HA, Chen Y, and Norkin LC. Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae. Mol Biol Cell 7: 1825-1834, 1996.
3. Bist A, Fielding PE, and Fielding CJ. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol. Proc Natl Acad Sci USA 94: 10693-10698, 1997.
4. Bretscher MS and Whytock S. Membrane-associated vesicles in fibroblasts. J Ultrastruct Res 61: 215-217, 1977.
5. Carman CV, Lisanti MP, and Benovic JL. Regulation of G protein-coupled receptor kinases by caveolin. J Biol Chem 274: 8858-8864, 1999.
6. Chapman HA, Wei Y, Simon DI, and Waltz DA. Role of urokinase receptor and caveolin in regulation of integrin signaling. Thromb Haemost 82: 291-297, 1999.
7. Cho KA and Park SC. Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration? Mech Ageing Dev 126: 105-110, 2005.
8. Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, Kim KT, Jang IS, and Park SC. Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279: 42270-42278, 2004.
9. Cho KA, Ryu SJ, Park JS, Jang IS, Ahn JS, Kim KT, and Park SC. Senescent phenotype can be reversed by reduction of caveolin status. J Biol Chem 278: 27789-27795, 2003.
10. Couet J, Li S, Okamoto T, Ikezu T, and Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem 272: 6525-6533, 1997.
11. Couet J, Sargiacomo M, and Lisanti MP. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins: caveolin-binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem 272: 30429-30438, 1997.
12. Cui J, Rohr LR, Swanson G, Speights VO, Maxwell T, and Brothman AR. Hypermethylation of the caveolin-1 gene promoter in prostate cancer. Prostate 46: 249-256, 2001.
13. Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, and Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 428: 205-211, 1998.
14. Engelman JA, Zhang XL, and Lisanti MP. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5′ promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett 448: 221-230, 1999.
15. Engelman JA, Zhang X, Galbiati F, Volonte D, Stogia F, Peseli RG, Minetti C, Scherer PE, Okamoto T, and Lisanti MP. Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet 63: 1578-1587, 1998.
16. Engqvist-Goldstein AE and Drubin DG. Actin assembly and endocytosis: from yeast to mammals. Annu Rev Cell Dev Biol 19: 287-332, 2003.
17. Fielding C, Bist A, and Fielding P. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci USA 94: 3753-3758, 1997.
18. Galbiati F, Volonté D, Liu J, Capozza F, Frank PG, Zhu L, Pestell RG, and Lisanti MP. Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell 12: 2229-2244, 2001.
19. Giancotti FG and Ruoslahti E. Integrin signaling. Science 285: 1028-1032, 1999.
20. Gingras D, Gauthier F, Lamy S, Desrosiers RR, and Beliveau R. Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains. Biochem Biophys Res Commun 247: 888-893, 1998.
21. Hailstones D, Sleer LS, Parton RG, and Stanley K. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res 39: 369-379, 1998.
22. Hall A. Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
23. Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK, and Black DM. Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene 18: 1881-1890, 1999.
24. Jang IS, Yeo EJ, Park JA, Ahn JS, Park JS, Cho KA, Juhnn YS, and Park SC. Altered cyclic AMP signaling induced by lysophosphatidic acid in senescent human diploid fibroblasts. Biochem Biophys Res Comm 302: 778-784, 2003.
25. Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I, and Lisanti MP. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem 270: 15693-15701, 1995.
26. Okada SS, Tomaszewski JE, and Barnathan ES. Migrating vascular smooth muscle cells polarize cell surface urokinase receptors after injury in vitro. Exp Cell Res 271: 180-187, 1995.
27. Okamoto T, Schlegel A, Schlegel PE, and Schlegel MP. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 273: 5419-5422, 1998.
28. Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, and Gundersen GG. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science 303: 836-839, 2004.
29. Parat MO, Anand-Apte B, and Fox PL. Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions. Mol Biol Cell 14: 3156-3168, 2003.
30. Park JS, Kim HY, Kim HW, Chae GN, Oh HT, Park JY, Shim H, Seo M, Shin EY, Kim EG, Park SC, and Kwak SJ. Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells. Mech Ageing Dev 126: 551-559, 2005.
31. Park JS, Park WY, Cho KA, Kim DI, Jhun BH, Kim SR, and Park SC. Downregulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in senescent cells. FASEB J 15: 1625-1627, 2001.
32. Park SC. Functional recovery of senescent cells through restoration of receptor-mediated endocytosis. Mech Aging Dev 123: 917-926, 2002.
33. Park WY, Park JS, Cho KA, Kim DI, Ko YG, Seo JS, and Park SC. Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem 275: 20847-20852, 2000.
34. Parton RG, Way M, Zorzi N, and Stang E. Caveolin-3 associates with developing T-tubules during muscle differentiation. J Cell Biol 136: 137-154, 1997.
35. Pelkmans L, Puntener D, and Helenius A. Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae. Science 296: 535-539, 2001.
36. Razani B and Lisanti MP. Caveolins and caveolae: molecular and functional relationships. Exp Cell Res 271: 36-44, 2001.
37. Razani B, Schlegel A, Liu J, and Lisanti MP. Caveolin-1, a putative tumour suppressor gene. Biochem Soc Trans 29: 494-499, 2001.
38. Rothberg KG, Ying Y, Kamen BA, and Anderson RGW. Cholesterol controls the clustering of the glycophopholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J Cell Biol 111: 2931-2938, 1990.
39. Sargiacomo M, Suldol M, Tang Z, and Lisanti MP. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol 122: 789-807, 1993.
40. Scherer PE, Lewis RY, Volonte D, Engelman JA, Galbiati F, Couet J, Kohtz DS, van Donselaar E, Peters P, and Lisanti MP. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem 272: 29337-29346, 1997.
41. Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, and Lisanti MP. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci USA 93: 131-135, 1996.
42. Schlegel A, Schwab RB, Scherer PE, and Lisanti MP. A role for the caveolin-scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin-scaffolding domain is both necessary and sufficient for membrane binding in vitro. J Biol Chem 274: 22660-22667, 1995.
43. Smart EJ, Ying Y, Donzell WC, and Anderson RG. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane. J Biol Chem 271: 29427-29435, 1996.
44. Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, and Lisanti MP. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem 271: 15160-15165, 1996.
45. Stang E, Kartenbeck J, and Parton RG. Major histocompatibility complex class I molecules mediate association of SV40 with caveolae. Mol Biol Cell 8: 47-57, 1997.
46. Tang Z, Scherer PE, Okamoto T, Song KC, Chu C, Kohtz DS, Nishimoto I, Lodish HF, and Lisanti MP. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem 271: 2255-2261, 1996.
47. Teixeira A, Chaverot N, Schroder C, Strosberg AD, Couraud PO, and Cazaubon S. Requirement of caveolae microdomains in extracellular signal-regulated kinase and focal adhesion kinase activation induced by endothelin-1 in primary astrocytes. J Neurochem 72: 120-128, 1999.
48. Volonté D, Zhang K, Lisanti MP, and Galbiati F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell 7: 2502-2517, 2002.
49. Wary KK, Mainiero F, Isakoff SJ, Marcantonio EE, and Giancotti FG. The adaptor protein She couples a class of integrins to the control of cell cycle progression. Cell 87: 733-743, 1996.
50. Wary KK, Mariotti A, Zurzolo C, and Giancotti FG. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94: 625-634, 1998.
51. Wei Y, Yang X, Liu Q, Wilkins JA, and Chapman HA. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol 144: 1285-1294, 1999.
52. Yeo EJ, Jang IS, Lim HK, Ha KS, and Park SC. Agonist-specific differential changes of cellular signal transduction pathways in senescent human diploid fibroblasts. Exp Gerontol 37: 871-883, 2002.
53. Yeo EJ and Park SC. Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging. Mech Ageing Dev 123: 563-578, 2002.