Emerging drugs for chronic urticaria

Expert Opinion on Emerging Drugs

Volumn 11, Issue 2, 2006, Pages 265-274

  Asero, Riccardo ^a   Tedeschi, Alberto ^b  

^a Ospedale 21   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Anticoagulants; Chronic urticaria; Heparin; Therapy

Indexed keywords

ACETYLCYSTEINE; ALKYLATING AGENT; ANTICOAGULANT AGENT; ANTIHISTAMINIC AGENT; CETIRIZINE; CHLORPHENIRAMINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DESLORATADINE; EBASTINE; FEXOFENADINE; HEPARIN; HYDROXYCHLOROQUINE; HYDROXYZINE; IMMUNOGLOBULIN; IMMUNOSTIMULATING AGENT; IMMUNOSUPPRESSIVE AGENT; KETOTIFEN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LEVOCETIRIZINE; LORATADINE; MIZOLASTINE; MONTELUKAST; NONSTEROID ANTIINFLAMMATORY AGENT; OXATOMIDE; PROMETHAZINE; UNINDEXED DRUG; WARFARIN; ZAFIRLUKAST;

ABSENCE OF SIDE EFFECTS; AUTOIMMUNE SKIN DISEASE; BLADDER DISEASE; BLOOD CLOTTING; CHRONIC URTICARIA; CLINICAL TRIAL; DIABETES MELLITUS; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPERTENSION; OSTEOPOROSIS; PATHOGENESIS; PLASMAPHERESIS; REVIEW; SKIN TEST; UNSPECIFIED SIDE EFFECT;

CHRONIC DISEASE; DRUGS, INVESTIGATIONAL; HUMANS; URTICARIA;

EID: 33646595383     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.11.2.265     Document Type: Review

References (98)

1. CHAMPION RH, ROBERTS SOB, CARPENTER RG, ROGER JH: Urticaria and angioedema - a review of 554 patients. Br. J. Dermatol. (1969) 81:588-597.
2. GREAVES MW: Chronic urticaria. J. Allergy Clin. Immunol. (2000) 105:664-672. A recent authoritative and comprehensive review of CU.
3. GREAVES MW: Chronic urticaria. N. Engl. J. Med. (1995) 332:1767-1772.
4. MONROE EW, JONES HE: Urticaria: an updated review. Arch. Dermatol. (1977) 113:80-90.
5. SIBBALD RG, CHEEMA AS, LOZINSKI A, TARLO S: Chronic urticaria: evaluation of the role of physical, immunologic and other contributory factors. Int. J. Dermatol. (1991) 30:381-386.
6. ASERO R: Chronic idiopathic urticaria: a family study. Ann. Allergy Asthma Immunol. (2002) 89:195-196. The only published study showing that, in accordance with its frequent autoimmune origin, CU is clearly a familiar disorder.
7. O'DONNELL BF, LAWLOR F, SIMPSON J, MORGAN M, GREAVES MW: The impact of urticaria on quality of life. Br. J. Dermatol. (1997) 136:197-201.
8. BAIARDINI I, GIARDINI A, PASQUALI M et al.: Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy. Allergy (2003) 58:621-623.
9. KAPLAN AP: Chronic urticaria and angioedema. N. Engl. J. Med. (2002) 346:175-179. A recent authoritative and comprehensive review of the disease.
10. MAY CD: Are confusion and controversy about food hypersensitivity really necessary? J. Allergy Clin. Immunol. (1985) 75:329-333.
11. DOEGLAS HM: Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias. Br. J. Dermatol. (1975) 93:135-144.
12. ZUBERBIER T, CHANTRAINE-HESS S, HARTMANN K, CZARNETZKI BM: Pseudoallergen-free diet in the treatment of chronic urticaria: a prospective study. Acta Derm. Venereol. (1995) 75:484-487.
13. GRATTAN CE, WALLINGTON TB, WARIN RP, KENNEDY CT, BRADFIELD JW: A serological mediator in chronic idiopathic urticaria - a clinical, immunological and histological evaluation. Br. J. Dermatol. (1986) 114:583-590.
14. GRUBER BL, BAEZA ML, MARCHESE MJ, AGNELLO V, KAPLAN AP: Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J. Invest. Dermatol. (1988) 90:213-217. The first study highlighting the autoimmune nature of some cases of CU.
15. GRATTAN CEH, FRANCIS DM, HIDE M, GREAVES MW: Detection of circulating histamine releasing autoantibodies with functional properties of anti IgE in chronic urticaria. Clin. Exp. Allergy (1991) 21:695-704.
16. HIDE M, FRANCIS DM, GRATTAN CEH, HAKIMI J, KOCHAN JP, GREAVES MW: Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N. Engl. J. Med. (1993) 328:1599-1604. The first detection of anti-FcεRI autoantibodies in patients with CU.
17. FIEBIGER E, MAURER D, HOLUB H et al.: Serum IgG autoantibodies directed against the alpha chain of FcεRI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J. Clin. Invest. (1995) 96:2606-2612.
18. FERRER M, KINET JP, KAPLAN AP: Comparative studies of functional and binding assays for IgG anti-FcεRIα (α-subunit). J. Allergy Clin. Immunol. (1998) 101:672-676.
19. FERRER M, NAKAZAWA K, KAPLAN AP: Complement dependence of histamine release in chronic urticaria. J. Allergy Clin. Immunol. (1999) 104:169-172.
20. KIKUCHI Y, KAPLAN AP: A role for C5a in augmenting IgE-dependent histamine release from basophils in chronic urticaria. J. Allergy Clin. Immunol. (2002) 109:114-118.
21. ELIAS J, BOSS E, KAPLAN AP: Studies of the cellular infiltrate of chronic idiopathic urticaria: prominence of T-lymphocytes, monocytes, and mast cells. J. Allergy Clin. Immunol. (1986) 78:914-918.
22. SABROE RA, POON E, ORCHARD GE et al.: Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcεRIα or anti-IgE autoantibodies. J. Allergy Clin. Immunol. (1999) 103:484-493.
23. WEDI B, NOVACEVIC V, KOERNER M, KAPP A: Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression - inhibitory effects of anti-inflammatory drugs. J. Allergy Clin. Immunol. (2000) 105:552-560.
24. CUNNINGHAM F: Lipid mediators in inflammatory skin disorders. J. Lipid Mediat. (1990) 2:61-74.
25. NORRIS JG, SULLIVAN TJ: Leukotriene and cytokines in steroid dependent chronic urticaria [abstract]. J. Allergy Clin. Immunol. (1998) 101(Suppl):S128.
26. ASERO R, TEDESCHI A, LORINI M, SALIMBENI R, ZANOLETTI T, MIADONNA A: Chronic urticaria: novel clinical and serological aspects. Clin. Exp. Allergy (2001) 31:1105-1110.
27. GREAVES MW, O'DONNELL BF: Not all chronic urticaria is 'idiopathic'. Exp. Dermatol. (1998) 7:11-13.
28. ASERO R, LORINI M, CHONG SU, ZUBERBIER T, TEDESCHI A: Assessment of histamine-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells. Clin. Exp. Allergy (2004) 34:1111-1114.
29. FAGIOLO U, KRICEK F, RUF C, PESERICO A, AMADORI A, CANCIAN M: Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria. J. Allergy Clin. Immunol. (2000) 106:567-572. This study showed that IgG depletion does not change outcome of the autologous serum skin test, suggesting for the first time that in vivo and in vivo tests might look at different aspects of the disease.
30. KERMANI F, NIIMI N, FRANCIS DM, O'DONNELL B, KOBZA-BLACK A, HAFISI S et al.: Characterization of a novel mast-cell specific histamine releasing activity in chronic idiopathic urticaria (CIU) [abstract]. J. Invest. Dermatol. (1995) 105:452.
31. CLAVEAU J, LAVOIE A, BRUNET C, BEDFORD PM, HILBER J: Chronic idiopathic urticaria: possible contribution of histamine releasing factor to the pathogenesis. J. Allergy Clin. Immunol. (1993) 92:132-137.
32. ASERO R, TEDESCHI A, RIBOLDI P, CUGNO M: Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum. J. Allergy Clin. Immunol. (2006) (in press).
33. RING J, BROCKOW K, OLLERT M, ENGST R: Antihistamines in urticaria. Clin. Exp. Allergy (1999) 29(Suppl. 1):31-37.
34. KALIVAS J, BRENEMAN D, THARP D, BRUCE S, BIGBY M: Urticaria: clinical efficacy of cetirizine in comparison with hydroxyzine and placebo. J. Allergy Clin. Immunol. (1990) 86:1014-1018.
35. BRENEMAN DL: Cetirizine versus hydroxyzine and placebo in chronic idiopathic urticaria. Ann. Pharmacother. (1996) 30:1075-1079.
36. FINN AF Jr, KAPLAN AP, FRETWELL R, QU R, LONG J: A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria. J. Allergy Clin. Immunol. (1999) 103:1071-1078.
37. MONROE EW: Loratadine in the treatment of urticaria. Clin. Ther. (1997) 19:232-242.
38. LORETTE G, GIANNETTI A, PEREIRA RS, LEYNADIER F, MURRIETA-AGUTTES M: One-year treatment of chronic urticaria with mizolastine: efficacy and safety. URTOL study group. J. Eur. Acad. Dermatol. Venereol. (2000) 14:83-90.
39. RING J, HEIN R, GAUGER A: Desloratadine in the treatment of chronic idiopathic urticaria. Allergy (2001) 56(Suppl. 65):28-32.
40. GRANT JA, DANIELSON L, RIHOUX JP, DE VOS D: A double blind, single dose, crossover comparison of cetirizine, elastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. Allergy (1999) 54:700-707. One of the few independent studies comparing the activity in vivo of several antihistamines.
41. WEDI B, KAPP A: Chronic urticaria: assessment of current treatment. Expert Rev. Clin. Immunol. (2005) 1:459-473. A very recent comprehensive and evidence-based review of urticaria therapy.
42. GOLDSOBEL AB, ROHR AS, SIEGEL SC et al.: Efficacy of doxepin in the treatment of chronic idiopathic urticaria. J. Allergy Clin. Immunol. (1986) 78:867-873.
43. KAPLAN AP: Chronic urticaria: pathogenesis and treatment. J. Allergy Clin. Immunol. (2004) 114:465-474. An excellent review of the pathogenesis and therapy of CU.
44. HARVEY RP, WEGS J, SCHOCKET AL: A controlled trial of therapy in chronic urticaria. J. Allergy Clin. Immunol. (1981) 68:262-266.
45. COMMENS CA, GREAVES MW: Cimetidine in chronic idiopathic urticaria: a randomised double-blind study. Br. J. Dermatol. (1978) 99:675-676.
46. BLEEHEN SS, THOMAS SE, GREAVES MW et al.: Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study. Br. J. Dermatol. (1987) 117:81-88.
47. LEWIS RA, AUSTEN KF, SOBERMAN RJ: Leukotrienes and other products of the 5-lipoxygenase pathway. N. Engl. J. Med. (1990) 323:645-645.
48. 4 in patients with chronic idiopathic urticaria and in normal subjects. J. Allergy Clin. Immunol. (1990) 86:759-765.
49. SPECTOR S, TAN RA: Antileukotrienes in chronic urticaria. J. Allergy Clin. Immunol. (1998) 101:572.
50. ELLIS MH: Successful treatment of chronic urticaria with leukotriene antagonists. J. Allergy Clin. Immunol. (1998) 102:876-877.
51. CHIU TJ, WARREN MS: Zafirlukast (ACCOLATE®) in the treatment of chronic idiopathic urticaria - a case series [abstract]. J. Allergy Clin. Immunol. (1998) 101(Suppl.):S155.
52. BENSCH G, BORISCH L: Leukotriene modifiers in chronic urticaria. Ann. Allergy Asthma Immunol. (1999) 83:348.
53. TEDESCHI A, LORINI M, SULI C, AIRAGHI L: Successful treatment of chronic urticaria. Allergy (2000) 55:1097-1098.
54. BERKUN Y, SHALIT M: Successful treatment of delayed pressure urticaria with montelukast. Allergy (2000) 55(2):203-204.
55. PACOR ML, DI LORENZO G, CORROCHER R: Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid. Clin. Exp. Allergy (2001) 31:1607-1614.
56. ERBAGCI Z: The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: a single blind, placebo controlled crossover clinical study. J. Allergy Clin. Immunol (2002) 110:484-488.
57. NETTIS E, COLANARDI MC, PARADISO MT, FERRANNINI A: Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double blind, placebo-controlled study. Clin. Exp. Allergy (2004) 34:1401-1407. A properly performed study showing that the association of antihistamines and leukotriene receptor antagonists is more effective than antihistamines alone in some patients with CU.
58. BAGENSTOSE SE, LEVIN L, BERNSTEIN JA: The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results. J. Allergy Clin. Immunol. (2004) 113:134-140.
59. REIMERS A, PICHLER C, HELBLING A, PICHLER WJ, YAWALKAR N: Zafirlukast has no beneficial effects in the treatment of chronic urticaria. Clin. Exp. Allergy (2002) 32:1763-1768.
60. DI LORENZO G, PACOR ML, MANSUETO P et al.: Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria. J. Allergy Clin. Immunol. (2004) 114:619-625.
61. SANADA S, TANAKA T, KAMEYOSHI Y, HIDE M: The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria. Arch. Dermatol. Res. (2005) 297:134-138
62. ASERO R, TEDESCHIA, LORINI M: Leukotriene receptors antagonists in chronic urticaria. Allergy (2001) 56:456-457.
63. ASERO R: Leukotriene receptor antagonists may prevent NSAID-induced exacerbations in patients with chronic urticaria. Ann. Allergy Asthma Immunol. (2000) 85:156-157.
64. CIRILLO R, TRIGGIANI M, SIRI L et al.: Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin. J. Immunol. (1990) 144:3891-3897.
65. FRADIN MS, ELLIS CN, GOLDFARB MT, VOORHEES JJ: Oral cyclosporine for severe chronic idiopathic urticaria and angioedema. J. Am. Acad. Dermatol. (1991) 25:1065-1067.
66. BARLOW RJ, KOBZA BLACK A, GREAVES MW: Treatment of severe, chronic urticaria with cyclosporin A. Eur. J. Dermatol. (1993) 3:273-275.
67. TOUBI E, BLANT A, KESSEL A, GOLAN TD: Low-dose cyclosporin A in the treatment of severe chronic idiopathic urticaria. Allergy (1997) 52:312-316.
68. GRATTAN CEH, O'DONNELL BF, FRANCIS DM et al.: Randomized double-blind study of cyclosporin in chronic 'idiopathic' urticaria. Br. J. Dermatol. (2000) 143:365-372. A well-performed study showing the usefulness of ciclosporin in unremitting urticaria.
69. GACH JE, SABROE RA, GREAVES MW, KOBZA BLACK A: Methotrexate-responsive chronic idiopathic urticaria: a report of two cases. Br. J. Dermatol. (2001) 145:340-343.
70. BERNSTEIN JA, GARRAMONE SM, LOWER EG: Successful treatment of autoimmune chronic idiopathic urticaria with intravenous cyclophosphamide. Ann. Allergy Asthma Immunol. (2002) 89:212-214.
71. ASERO R: Oral cyclophosphamide in a case of cyclosporin and steroid-resistant chronic urticaria showing autoreactivity on autologous serum skin testing. Clin. Exp. Dermatol. (2005) 30:582-583.
72. KAZATCHINE MD, KAVERI SV: Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N. Engl. J. Med. (2001) 345:747-755.
73. MOUTHON L, KAVERI SV, SPALTER SH et al.: Mechanisms of action of intravenous immune globulin in immune-mediated diseases. Clin. Exp. Immunol. (1996) 104(Suppl. 1):3-9.
74. O'DONNELL BF, BARR RM, KOBZA BLACK A, FRANCIS DM, GREAVES MW: Intravenous immunoglobulin in chronic autoimmune urticaria. Br. J. Dermatol (1998) 138:101-106.
75. ASERO R: Are IVIG for chronic unremitting urticaria effective? Allergy (2000) 55:1099-1101.
76. GRATTAN CEH, FRANCIS DM, SLATER NGP, BARLOW RJ, GREAVES MW: Plasmapheresis for severe unremitting chronic urticaria. Lancet (1992) 339:1078-1080.
77. LOPEZ LR, DAVIS KC, KOHLER PF, SCHOCKET AL: The hypocomplementemic urticarial-vasculitis syndrome: therapeutic response to hydroxychloroquine. J. Allergy Clin. Immunol. (1984) 73:600-603.
78. BAUMGART KW, MULLINS R: Use of hydroxychloroquine in refractory urticaria. J. Allergy Clin. Immunol. (2000) 105:795-796.
79. REEVES GE, BOYLE MJ, BONFIELD J, DOBSON P, LOEWENTHAL M: Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation. Intern. Med. J. (2004) 34:182-186.
80. JAFFER AM: Sulfasalazine in the treatment of corticosteroid-dependent chronic idiopathic urticaria. J. Allergy Clin. Immunol. (1991) 88:964-965.
81. HARTMANN K, HANI N, HINRICHS R, HUNZELMANN N, SCHARFFETTER-KOLHANEK K: Successful sulfasalazine treatment of severe chronic idiopathic urticaria associated with pressure urticaria. Acta Derm. Venereol. (2001) 81:71.
82. BOEHM I, BAUER R, BIEBER T: Urticaria treated with dapsone. Allergy (1999) 54:765-766.
83. KESSEL A, BAMBERGER E, TOUBI E: Tacrolimus in the treatment of severe chronic idiopathic urticaria: an open-label prospective study. J. Am. Acad. Dermatol. (2005) 52:145-148.
84. RUMBYRT JS, KATZ JL, SCHOCKET AL: Resolution of chronic urticaria in patients with thyroid autoimmunity. J. Allergy Clin. Immunol. (1995) 96:901-905.
85. HEYMANN WR: Chronic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications. J. Am. Acad. Dermatol. (1999) 40:229-232.
86. BRESTEL EP, TRUSH LB: The treatment of glucocorticoid-dependent chronic urticaria with stanozolol. J. Allergy Clin. Immunol. (1988) 82:265-269.
87. FAGIOLO U, CANCIAN M, BERTOLLO L, PESERICO A, AMADORI A: Inhibitory effect of heparin on skin reactivity to autologous serum in chronic idiopathic urticaria. J. Allergy Clin. Immunol. (1999) 103:1143-1147.
88. ANTCZAK-MARCZAK A, KUNA P: The effect of heparin on release of histamine from basophils under the influence of MCAF/MCP-1 in patients with bronchial asthma. Pneumonol. Alergol. Pol. (1997) 65:581-587.
89. ANTCZAK-MARCZAK A, KUNA P: The influence of heparin on histamine level in plasma during early reaction phase of asthma. Pol. Arch. Med. Wewn. (1997) 97:7-14.
90. JACKSON RL, BUSH SJ, CARDIN AD: Glycosaminoglycans: molecular properties, protein interactions and role in physiologic processes. Physiol. Rev. (1991) 71:481-539.
91. BOWLER SD, SMITH SM, LAVERCOMBE PS: Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am. Rev. Respir. Dis. (1993) 147:160-163.
92. CHUA SL, GIBBS. Chronic urticaria responding to subcutaneous heparin sodium. Br. J. Dermatol. (2005) 153:216-217. This is the first report of the efficacy of heparin in CU.
93. DUVALL LA, BOACKLE RJ, KING RG: Warfarin sodium therapy for chronic urticaria and angioedema. South Med. J. (1986) 79:389.
94. BERTH-JONES J, HUTCHINSON PE, WICKS ACB, MITCHELL VE: Chronic urticaria with angio-oedema controlled by warfarin. Br. Med. J. (1988) 297:1382-1383.
95. BARLOW RJ, GREAVES MW: Warfarin in the treatment of chronic urticaria/angio-oedema. Br. J. Dermatol. (1992) 126:415-416.
96. PARSLEW R, PRYCE D, ASHWORTH J, FRIEDMANN PS: Warfarin treatment of chronic idiopathic urticaria and angio-oedema. Clin. Exp. Allergy (2000) 30:1161-1165. A properly performed study of oral anticoagulant therapy in CU.
97. KAPLANSKI G, FABRIGOULE M, BOULAY V et al.: Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-α-independent IL-8 secretion and E-selectin expression. J. Immunol. (1997) 158:5435-5441.
98. BEROVA N, PETKOVA I, ANDREEV VC: Treatment of chronic urticaria with a proteinase (kallikrein) inhibitor. Br. J. Dermatol. (1974) 90:431-434.