Deep venous thrombosis in a patient with Behçet's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills

Rheumatology International

Volumn 26, Issue 8, 2006, Pages 758-759

  Uthman, Imad ^a   Otrock, Zaher ^a   Taher, Ali ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Behcet's disesase; Prothrombin; Vasculopathy

Indexed keywords

ANTICOAGULANT AGENT; COLCHICINE; ORAL CONTRACEPTIVE AGENT; PREDNISONE; PROTHROMBIN;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; BEHCET DISEASE; CASE REPORT; DEEP VEIN THROMBOSIS; DOPPLER ECHOGRAPHY; FEMALE; GENE MUTATION; GENITAL ULCER; HUMAN; MOUTH ULCER; ORAL CONTRACEPTION; PRIORITY JOURNAL; SAPHENOUS VEIN; THROMBOPHILIA;

ADULT; BEHCET SYNDROME; CONTRACEPTIVES, ORAL; FEMALE; HOMOZYGOTE; HUMANS; MUTATION; PROTHROMBIN; VENOUS THROMBOSIS;

EID: 33646589992     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-005-0048-5     Document Type: Article

References (16)

1. Lie JT (1992) Vascular involvement in Behcet's disease: arterial and venous and vessels of all sizes. J Rheumatol 19(3):341-343
2. Salvarani C, Calamia K, Silingardi M, Ghirarduzzi A, Olivieri I (2000) Thrombosis associated with the prothrombin G → A20210 mutation in Behcet's disease. J Rheumatol 27(2):515-516
3. Leiba M, Sidi Y, Gur H, Leiba A, Ehrenfeld M (2001) Behcet's disease and thrombophilia. Ann Rheum Dis 60(12):1081-1085
4. Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM (1998) High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. N Engl J Med 338(25):1793-1797
5. Uthman I, Kassak K, Sanjakdar R, Mendelek V, Masri AF, Nasr FW (1997) Letter from Lebanon. Br J Rheumatol 36(7):806-807
6. Bertina RM (1998) The prothrombin 20210 G to A variation and thrombosis. Curr Opin Hematol 5(5):339-342
7. Akar N, Misirlioglu M, Akar E, Avcu F, Yalcin A, Sozuoz A (1998) Prothrombin gene 20210 G-A mutation in the Turkish population. Am J Hematol 58(3):249
8. Taher A, Khalil I, Abou-Merhi R, Shamseddine A, Bazarbachi A (2003) High prevalence of prothrombin G20210A mutation among patients with deep venous thrombosis in Lebanon. Thromb Haemost 89(5):945-946
9. Howard TE, Marusa M, Channell C, Duncan A (1997) A patient homozygous for a mutation in the prothrombin gene 3′-untranslated region associated with massive thrombosis. Blood Coagul Fibrinolysis 8(5):316-319
10. Vayá A, Villa P, Mira Y, Ferrando F, Aznar J, Estellés A, et al (2000) Intracardiac thrombosis in a case of Behcet's disease associated with a prothrombin 20210G-A mutation. Haematologica 85(4):425-428
11. Tursen U, Kaya TI, Eskandari G, Gunduz O, Yazar M, Ikizoglu G et al (2001) Association of factor V Leiden and prothrombin gene mutation with Behçet's disease. Arch Dermatol Res 293(10):537-539
12. Espinosa G, Font J, Tàssies D, Vidaller A, Deulofeu R, López-Soto A, et al (2002) Vascular involvement in Behçet's disease: Relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 112(1):37-43
13. Silingardi M, Salvarani C, Boiardi L, Accardo P, Iori I, Iorio A et al (2004) Factor V Leiden and Prothrombin Gene G20210A mutations in Italian patients with Behçet's disease and deep vein thrombosis. Arthritis Care Res 51(2):177-183
14. Gul A, Aslantas AB, Tekinay T, Konice M, Ozcelik T (1999) Procoagulant mutations and venous thrombosis in Behcet's disease. Rheumatol (Oxford) 38(12):1298-1299
15. Toydemir PB, Elhan AH, Tukun A, Toydemir R, Gurler A, Tuzuner A et al (2000) Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombogenesis in Behcet's disease. J Rheumatol 27(12):2849-2854
16. Taher A, Khalil I, Shamseddine A, El-Ahdab F, Bazarbachi A (2001) High prevalence of Factor V Leiden mutation among healthy individuals and patients with deep venous thrombosis in Lebanon: is the eastern Mediterranean region the area of origin of this mutation? Thromb Haemost 86(2):723-724