The immunophilin FKBP52 inhibits the activity of the epithelial Ca 2+ channel TRPV5

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 5, 2006, Pages

  Gkika, Dimitra ^a   Topala, Catalin N ^a   Hoenderop, Joost G J ^a   Bindels, René J M ^a,b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Ca2+ homeostasis; ECaC; FK506; Ion channel; Tacrolimus

Indexed keywords

CALCIUM; CYCLOPHILIN; DRUG RECEPTOR; DRUG VEHICLE; FK 506 BINDING PROTEIN; IMMUNOPHILIN; PROTEIN FKBP52; PROTEIN TRPV5; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CATALYSIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; MALE; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT;

EID: 33646574298     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00298.2005     Document Type: Article

References (30)

1. Aicher L, Meier G, Norcross AJ, Jakubowski J, Varela MC, Cordier A, and Steiner S. Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization. Biochem Pharmacol 53: 723-731, 1997.
2. Allison AC. Novel immunosuppressive and antiinflammatory drugs. A 1993 perspective. Ann N Y Acad Sci 696: xi-xx, 1993.
3. Andoh TF, Burdmann EA, Fransechini N, Houghton DC, and Bennett WM. Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. Kidney Int 50: 1110-1117, 1996.
4. 3 and PTH. Am J Physiol Renal Fluid Electrolyte Physiol 261: F799-F807, 1991.
5. Brummelkamp TR, Bernards R, and Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553, 2002.
6. r 90,000 heat shock protein: main structural features of a mammalian p59 protein. Proc Natl Acad Sci USA 89: 6270-6274, 1992.
7. Galigniana MD, Radanyi C, Renoir JM, Housley PR, and Pratt WB. Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus. J Biol Chem 276: 14884-14889, 2001.
8. 2+ channel TRPV5 in health and disease. J Med Sci 24: 291-299, 2004.
9. 2+ channel transient receptor potential cation channel V5 (TRPV5). J Biol Chem 279: 26351-26357, 2004.
10. Goel M, Garcia R, Estacion M, and Schilling WP. Regulation of Drosophila TRPL channels by immunophilin FKBP59. J Biol Chem 276: 38762-38773, 2001.
11. Gothel SF and Marahiel MA. Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci 55: 423-436, 1999.
12. 3-1α-hydroxylase knockout mice. Kidney Int 65: 531-539, 2004.
13. 3-1α-hydroxylase knockout mice. FASEB J 16: 1398-1406, 2002.
14. 2+ channel in rabbit kidney and intestine. J Am Soc Nephrol 11: 1171-1178, 2000.
15. 3-responsive epithelia. J Biol Chem 274: 8375-8378, 1999.
16. Hoenderop JG, van der Kemp AW, Hartog A, van Os CH, Willems PH, and Bindels RJ. The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium. Biochem Biophys Res Commun 261: 488-492, 1999.
17. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112: 1906-1914, 2003.
18. Ivery MT. Immunophilins: switched on protein binding domains? Med Res Rev 20: 452-484, 2000.
19. Krieg PA and Melton DA. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res 12: 7057-7070, 1984.
20. Le Bihan S, Renoir JM, Radanyi C, Chambraud B, Joulin V, Catelli MG, and Baulieu EE. The mammalian heat shock protein binding immunophilin (p59/HBI) is an ATP and GTP binding protein. Biochem Biophys Res Commun 195: 600-607, 1993.
21. 2+ transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol 15: 549-557, 2004.
22. Riggs DL, Roberts PJ, Chirillo SC, Cheung-Flynn J, Prapapanich V, Ratajczak T, Gaber R, Picard D, and Smith DF. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J 22: 1158-1167, 2003.
23. Rosen MK, Standaert RF, Galat A, Nakatsuka M, and Schreiber SL. Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate. Science 248: 863-866, 1990.
24. Ruff VA, Yem AW, Munns PL, Adams LD, Reardon IM, Deibel MR Jr, and Leach KL. Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody. J Biol Chem 267: 21285-21288, 1992.
25. Sanokawa-Akakura R, Dai H, Akakura S, Weinstein D, Fajardo JE, Lang SE, Wadsworth S, Siekierka J, and Birge RB. A novel role for the immunophilin FKBP52 in copper transport. J Biol Chem 279: 27845-27848, 2004.
26. Schiene C and Fischer G. Enzymes that catalyse the restructuring of proteins. Curr Opin Struct Biol 10: 40-45, 2000.
27. Silverstein AM, Galigniana MD, Kanelakis KC, Radanyi C, Renoir JM, and Pratt WB. Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein. J Biol Chem 274: 36980-36986, 1999.
28. Sinkins WG, Goel M, Estacion M, and Schilling WP. Association of immunophilins with mammalian TRPC channels. J Biol Chem 279: 34521-34529, 2004.
29. Trouet D, Nilius B, Voets T, Droogmans G, and Eggermont J. Use of a bicistronic GFP-expression vector to characterise ion channels after transfection in mammalian cells. Pflügers Arch 434: 632-638, 1997.
30. 2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J 22: 1478-1487, 2003.