MR contrast agents in lymph node imaging

European Journal of Radiology

Volumn 58, Issue 3, 2006, Pages 375-382

  Misselwitz, Bernd ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Contrast agents; Lymph node metastases; MR imaging; MR lymphography

Indexed keywords

DISEASE CONTROL; IRON OXIDES; MEDICAL IMAGING; PATIENT TREATMENT; TUMORS;

CONTRAST AGENTS; LYMPH NODE METASTASES; MR LYMPHOGRAPHY;

MAGNETIC RESONANCE IMAGING;

CONTRAST MEDIUM; DEXTRAN; GADOBUTROL; GADOFLUORINE 8; GADOFLUORINE M; GADOFOSVESET; GADOLINIUM; GADOLINIUM PENTETATE; GADOMELITOL; GADOMER 17; GADOTERATE MEGLUMINE; NC 22181; NC 66368; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; P760; PENTETIC ACID; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ARTICLE; DIAGNOSTIC PROCEDURE; HUMAN; IMAGING; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHOGRAPHY; LYMPHOMA; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TECHNIQUE;

CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; FERRIC COMPOUNDS; HUMANS; IMAGE ENHANCEMENT; LYMPH NODES; LYMPHATIC METASTASIS; LYMPHOGRAPHY; MAGNETIC RESONANCE IMAGING; NEOPLASM STAGING; ORGANOMETALLIC COMPOUNDS; TIME FACTORS;

EID: 33646561584     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2005.12.044     Document Type: Article

References (51)

1. Recht A., and Houlihan M.J. Axillary lymph nodes and breast cancer: a review. Cancer 76 (1995) 1491-1512
2. Hricak H. Imaging of the genitourinary system. Acad Radiol 2 (1995) S159-S160
3. Anzai Y., Brunberg J.A., and Lufkin R.B. Imaging of nodal metastases in the head and neck. J Magn Reson Imaging 7 (1997) 774-783
4. The American Thoracic Society and The European Respiratory Society. Pretreatment evaluation of non-small-cell lung cancer. Am J Respir Crit Care Med 1997; 156:320-332.
5. Gershenwald J., Thompson W., Mansfield P., et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 17 (1999) 976-983
6. Laissy J.-P., Gay-Depassier P., Soyer P., et al. Enlarged mediastinal lymph nodes in bronchogenic carcinoma: assessment with dynamic contrast-enhanced MR imaging. Radiology 191 (1994) 263-267
7. van den Brekel M.W. Lymph node metastases: CT and MRI. Eur J Radiol 33 (2000) 230-238
8. Murray A.D., Staff R.T., Redpath T.W., et al. Dynamic contrast enhanced MRI of the axilla in women with breast cancer: comparison with pathology of excised nodes. Br J Radiol 75 (2002) 220-228
9. Luciani A., Dao T.H., Lapeyre M., et al. Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: preliminary results. Am J Roentgenol 182 (2004) 1059-1067
10. Harika L., Weissleder R., Poss K., and Papisov M.I. Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies. Radiology 198 (1996) 365-370
11. Moghimi S.M., and Bonnemain B. Subcutaneous and intravenous delivery of diagnostic agents to the lymphatic system: applications in lymphoscintigraphy and indirect lymphography. Adv Drug Deliv Rev 37 (1999) 295-312
12. Steinkamp H.J., Cornehl M., Hosten N., Pegios W., Vogl T., and Felix R. Cervical lymphadenopathy: ratio of long- to short-axis diameter as a predictor of malignancy. Br J Radiol 68 (1995) 266-270
13. Mohr U., and Weissleder R. Lymphknotendiagnostik mit bildgebenden Verfahren. Ein Überblick mit besonderer Berücksichtigung der letzten Entwicklungen im Bereich der MR-Kontrastmittel. Z Lymphol 20 (1996) 15-20
14. Vassallo P., Matei C., Heston W.D.W., McLachlan S.J., Koutcher J.A., and Castellino R.A. AMI-227-enhanced MR lymphography: usefulness for differentiating reactive from tumor-bearing lymph nodes. Radiology 193 (1994) 501-506
15. Taupitz M., Wagner S., and Hamm B. Kontrastmittel für die magnetresonanztomographische Lymphknotendiagnostik (MR Lymphographie). Radiologe 36 (1996) 134-140
16. Witte C.L., Williams W.H., and Witte M.H. Lymphatic imaging (editorial). Lymphology 26 (1993) 109-111
17. Weissleder R., Elizondo G., Wittenberg J., Lee A.S., Josephson L., and Brady T.J. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology 175 (1990) 494-498
18. 1-type MR contrast agent: Gd-DTPA-PGM. MRM 33 (1995) 88-92
19. Vassallo P., Matei C., Heston W.D.W., McLachlan S.J., Koutcher J.A., and Castellino R.A. Characterization of reactive versus tumor-bearing lymph nodes with interstitial magnetic resonance lymphography in an animal model. Invest Radiol 30 (1995) 706-711
20. Suga K., Yuan Y., Ogasawara N., Okada M., and Matsunaga N. Localization of breast sentinel lymph nodes by MR lymphography with a conventional gadolinium contrast agent. Preliminary observations in dogs and humans. Acta Radiol 44 (2003) 35-42
21. Ruehm S.G., Corot C., and Debatin J.F. Interstitial MR lymphography with a conventional extracellular gadolinium-based agent: assessment in rabbits. Radiology 218 (2001) 664-669
22. Ruehm S.G., Schroeder T., and Debatin J.F. Interstitial MR lymphography with gadoterate meglumine: initial experience in humans. Radiology 220 (2001) 816-821
23. Fink C., Bock M., Kiessling F., and Delorme S. Interstitial magnetic resonance lymphography with gadobutrol in rats: evaluation of contrast kinetics. Invest Radiol 37 (2002) 655-662
24. Misselwitz B., and Sachse A. Interstitial MR lymphography using Gd-carrying liposomes. Acta Radiol 38 (1997) 51-55
25. Torchilin V.P., Trubetskoy V.S., Milshteyn A.M., et al. Targeted delivery of diagnostic agents by surface-modified liposomes. J Contr. Release 28 (1994) 45-58
26. Trubetskoy V.S., Canillo J.A., Milshtein A., Wolf G.L., and Torchilin V.P. Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties. MRI 13 (1995) 31-37
27. Weissleder R., Elizondo G., Josephson L., et al. Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology 171 (1989) 835-839
28. Bengele H., Palmacci S., Rogers J., Jung C., Crenshaw J., and Josephson L. Biodistribution of an ultrasmall superparamagnetic iron oxide colloid, BMS 180549, by different routes of administration. Magn Reson Imaging 12 (1994) 433-442
29. Misselwitz B., Schmitt-Willich H., Michaelis M., and Oellinger J.J. Interstitial magnetic resonance lymphography using a polymeric T1 contrast agent: initial experience with gadomer-17. Invest Radiol 37 (2002) 146-151
30. Herborn C.U., Vogt F.M., Lauenstein T.C., et al. Assessment of normal, inflammatory, and tumor-bearing lymph nodes with contrast-enhanced interstitial magnetic resonance lymphography: preliminary results in rabbits. J Magn Reson Imaging 18 (2003) 328-335
31. Kobayashi H., Kawamoto S., Star R.A., Waldmann T.A., Tagaya Y., and Brechbiel M.W. Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent. Cancer Res 63 (2003) 271-276
32. Kobayashi H., Kawamoto S., Sakai Y., et al. Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J Natl Cancer Inst 96 (2004) 703-708
33. Staatz G., Nolte-Ernsting C.C., Bucker A., et al. Interstitial T1-weighted MR lymphography with use of the dendritic contrast agent Gadomer-17 in pigs. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 173 (2001) 1131-1136
34. Staatz G., Spuntrup E., Buecker A., Misselwitz B., and Gunther R.W. T1 weighted MR-lymphography after intramammary administration of Gadomer-17 in pigs. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 174 (2002) 29-32
35. Torchia M.G., and Misselwitz B. Combined MR lymphangiography and MR imaging-guided needle localization of sentinel lymph nodes using Gadomer-17. AJR Am J Roentgenol 179 (2002) 1561-1565
36. Desser T.S., Rubin D.L., Muller H., McIntire G.L., Bacon E.R., and Hollister K.R. Interstitial MR and CT lymphography with Gd-DTPA-co-α, ω-diaminoPEG(1450) and Gd-DTPA-co-1,6-diaminohexane polymers: preliminary experience. Acad Radiol 6 (1999) 112-118
37. Misselwitz B., Platzek J., Raduchel B., Oellinger J.J., and Weinmann H.J. Gadofluorine 8: initial experience with a new contrast medium for interstitial MR lymphography. Magma 8 (1999) 190-195
38. Staatz G., Nolte-Ernsting C.C., Adam G.B., et al. Interstitial T1-weighted MR lymphography: lipophilic perfluorinated gadolinium chelates in pigs. Radiology 220 (2001) 129-134
39. Clement O., and Luciani A. Imaging the lymphatic system: possibilities and clinical applications. Eur Radiol 14 (2004) 1498-1507
40. Taupitz M., Wagner S., Hamm B., Binder A., and Pfefferer D. Interstitial MR lymphography with iron oxide particles: results in tumor-free and VX2 tumor-bearing rabbits. Am J Roentgenol 161 (1993) 193-200
41. Misselwitz B., Schmitt-Willich H., Ebert W., Frenzel T., and Weinmann H. Pharmacokinetics of Gadomer-17, a new dendritic magnetic resonance contrast agent. Magma 12 (2001) 128-134
42. Herborn C.U., Barkhausen J., Paetsch I., et al. Coronary arteries: contrast-enhanced MR imaging with SH L 643A-experience in 12 volunteers. Radiology 229 (2003) 217-223
43. Herborn C.U., Lauenstein T.C., Vogt F.M., Lauffer R.B., Debatin J.F., and Ruehm S.G. Interstitial MR lymphography with MS-325: characterization of normal and tumor-invaded lymph nodes in a rabbit model. Am J Roentgenol 179 (2002) 1567-1572
44. Anzai Y., Blackwell K.E., Hirschowitz S.L., et al. Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. Radiology 192 (1994) 709-715
45. Weissleder R., Heautot J.F., Schaffer B.K., et al. MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology 191 (1994) 225-230
46. Weissleder R., Elizondo G., Wittenberg J., Rabito C.A., Bengele H.H., and Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175 (1990) 489-493
47. Bellin M.F., Roy C., Kinkel K., et al. Lymph node metastases: safety and effectiveness of MR imaging with ultrasmall superparamagnetic iron oxide particles-initial clinical experience. Radiology 207 (1998) 799-808
48. Rety F., Clement O., Siauve N., et al. MR lymphography using iron oxide nanoparticles in rats: pharmacokinetics in the lymphatic system after intravenous injection. J Magn Reson Imaging 12 (2000) 734-739
49. Ikomi F., Hanna G.K., and Schmid-Schönbein G.W. Mechanism of colloidal particle uptake into the lymphatic system: basic study with percutaneous lymphography. Radiology 196 (1995) 107-113
50. Misselwitz B., Platzek J., and Weinmann H.-J. Early MR lymphography with Gadofluorine M in rabbits. Radiology 231 (2004) 682-688
51. Hovels A.M., Heesakkers R.A., Adang E.M., Jager G.J., and Barentsz J.O. Cost-analysis of staging methods for lymph nodes in patients with prostate cancer: MRI with a lymph node-specific contrast agent compared to pelvic lymph node dissection or CT. Eur Radiol 14 (2004) 1707-1712