Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1)

Diabetes Research and Clinical Practice

Volumn 72, Issue 3, 2006, Pages 223-230

  Ishibashi, Fukashi ^a  

^a Ishibashi Clinic   (Japan)

Author keywords

Acidification machinery; Albumin reabsorption; High glucose; Lysosomal alkalinization; Proximal tubular epithelial cells

Indexed keywords

4,4' DIISOTHIOCYANATO 2'2' DISULFONIC ACID; ADENOSINE TRIPHOSPHATASE; ALBUMIN; AMILORIDE DERIVATIVE; BAFILOMYCIN A1; CHLORIDE CHANNEL; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; GLUCOSE; MESSENGER RNA; N ETHYL N ISOPROPYL AMILORIDE; PHLORIZIN; SODIUM ION; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACIDIFICATION; ALKALINIZATION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN; DRUG INHIBITION; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; LYSOSOME; NONHUMAN; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; SWINE;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ALBUMINS; AMILORIDE; ANIMALS; EPITHELIAL CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; GLUCOSE; HYDROGEN-ION CONCENTRATION; KIDNEY TUBULES, PROXIMAL; LLC-PK1 CELLS; LYSOSOMES; MACROLIDES; SUS SCROFA;

EID: 33646557057     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2005.10.019     Document Type: Article

References (29)

1. Ishibashi F. Microalbuminuria in NIDDM is caused by increased excretion of unmodified albumin. Diabetes 45 (1996) 731-736
2. Tucker B.J., Rasch R., and Blantz R.C. Glomerular filtration and tubular reabsorption of albumin in preproteinuric diabetic rats. J. Clin. Invest. 92 (1993) 686-694
3. 1). Diab. Res. Clin. Pract. 63 (2004) 217-225
4. Mellman I., Fuchs R., and Helenius A. Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55 (1986) 663-700
5. Marshansky V., Bourgoin S., Londono I., Bendayan M., Maranda B., and Vinay P. Receptor-mediated endocytosis in kidney proximal tubule: recent advances and hypothesis. Electrophoresis 18 (1997) 2661-2676
6. Leber P.D., and Marsh D.J. Micropuncture study of concentration and fate of albumin in rat nephron. Am. J. Physiol. 219 (1970) 358-363
7. Holopainen J.M., Saarikoski J., Kinnunen P.K.J., and Järvela I. Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs). Eur. J. Biochem. 268 (2001) 5851-5856
8. Noël J., Tejedor A., Vinay P., and Laprade R. Substrate-induced modulation of ATP turnover in dog and rabbit proximal tubules. J. Memb. Biol. 128 (1992) 205-218
9. 1. In Vitro 12 (1976) 670-677
10. 1): a model system for aminoglycoside nephrotoxicity. J. Pharm. Exp. Therap. 230 (1984) 742-748
11. 1. Cell. Mol. Biol. 44 (1998) 1051-1060
12. Nelson N., and Harvey W.R. Vacuolar and plasma membrane proton-adenosine triphosphatase. Physiol. Rev. 79 (1999) 361-385
13. + exchangers. J. Biol. Chem. 275 (2000) 1-4
14. Diwu Z., Chen C.S., Zhang C., Klaubert D.H., and Haugland R.P. A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells. Chem. Biol. 6 (1999) 411-418
15. Haugland R.P. Probes for lysosomes, yeast vacuoles and other acidic organelles. In: Haugland R.P. (Ed). Handbook of Fluorescent Probes and Research Products. ninth ed. (2001), Eugene 489-496
16. +-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 266 (1991) 17707-17712
17. i in renal proximal tubular cells. Kidney Int. 54 (1998) 1206-1213
18. +-ATPase. J. Biol. Chem. 279 (2004) 8732-8739
19. +-ATPase, and protein kinase C activity in proximal tubule cells. Diabetes 44 (1995) 446-452
20. +-ATPase that redistributes to apical membrane during ATP depletion remains functional. Am. J. Physiol. 265 (1993) F693-F697
21. Sasaki Y., Nagai J., Kitahara Y., Takai N., Murakami T., and Takano M. Expression of chloride channel, ClC-5, and its role in receptor-mediated endocytosis of albumin in OK cells. Biochem. Biophy. Res. Comm. 282 (2001) 212-218
22. Gekle M. Renal tubule albumin transport. Annu. Rev. Physiol. 67 (2005) 12.1-12.22
23. + exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion. J. Physiol. 531.1 (2001) 619-629
24. 1. J. Biol. Chem. 275 (2000) 37765-37773
25. Hryciw D.H., Wang Y., Devuyst O., Pollock C.A., Poronnik P., and Guggino W.B. Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell line. J. Biol. Chem. 278 (2003) 40169-40176
26. Hryciw D.H., Lee E.M., Pollock C.A., and Poronnik P. Molecular changes in proximal tubule function in diabetes mellitus. Clin. Exp. Pharma. Physiol. 31 (2004) 372-379
27. Wang S.S., Devuyst O., Courtoy P.J., Wang X.T., Wang H., Wang Y., et al. Mice lacking renal chloride channel, ClC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum. Mol. Genet. 9 (2000) 2937-2945
28. Christensen E.I., Devuyst O., Dom G., Nielsen R., der Van S.P., Verroust P., et al. Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8472-8477
29. Clarkson M.R., Murphy M., Gupta S., Lambe T., Mackenzie H.S., Godson C., et al. High glucose-altered gene expression in mesangial cells. J. Biol. Chem. 277 (2002) 9707-9712