Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: Initial identification of predictive biomarkers

European Journal of Immunology

Volumn 36, Issue 5, 2006, Pages 1337-1349

  Elia, Leonardo ^a   Mennuni, Carmela ^a   Storto, Mariangela ^a   Podda, Silvia ^a   Calvaruso, Francesco ^a   Salucci, Valentina ^a   Aurisicchio, Luigi ^a   Scarito, Alessia ^a   Ciliberto, Gennaro ^a   La Monica, Nicola ^a   Palombo, Fabio ^a  

^a IRBM   (Italy)

Author keywords

Cancer vaccine; Cell mediated immune response; Tumor associated antigen

Indexed keywords

ADENOVIRUS VECTOR; BIOLOGICAL MARKER; CANCER VACCINE; EPITHELIAL CELL ADHESION MOLECULE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE DERIVATIVE; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CANCER IMMUNOTHERAPY; CLINICAL PROTOCOL; COLORECTAL CANCER; CONTROLLED STUDY; ELECTROPORATION; ENZYME LINKED IMMUNOSPOT ASSAY; HAPLOTYPE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MACACA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RHESUS MONKEY;

ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; BIOLOGICAL MARKERS; CANCER VACCINES; CELL ADHESION MOLECULES; IMMUNE TOLERANCE; MACACA MULATTA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MOLECULAR SEQUENCE DATA; VACCINATION; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 33646538164     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535514     Document Type: Article

References (33)

1. Momburg, F., Moldenhauer, G., Hammerling, G. J. and Moller, P., Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues. Cancer Res. 1987. 47: 2883-2891.
2. Balzar, M., Briaire-de Bruijn, I. H., Rees-Bakker, H. A., Prins, F. A., Helfrich, W., de Leij, L., Riethmuller, G. et al., Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol. Cell. Biol. 2001. 21: 2570-2580.
3. Balzar, M., Winter, M. J., de Boer, C. J. and Litvinov, S. V., The biology of the 17-1A antigen (Ep-CAM). J. Mol. Med. 1999. 77: 699-712.
4. Armstrong, A. and Eck, S. L., EpCAM: A new therapeutic target for an old cancer antigen. Cancer Biol. Ther. 2003. 2: 320-326.
5. Went, P. T., Lugli, A., Meier, S., Bundi, M., Mirlacher, M., Sauter, G. and Dirnhofer, S., Frequent EpCam protein expression in human carcinomas. Hum. Pathol. 2004. 35: 122-128.
6. Osta, W. A., Chen, Y., Mikhitarian, V, Mitas, M., Salem, M., Hannun, Y. A., Cole, D. J. et al., EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004. 64: 5818-5824.
7. Mosolits, S., Harmenberg, U., Ruden, U., Ohman, L., Nilsson, B., Wahren, B., Fagerberg, J. et al., Autoantibodies against the tumour-associated antigen GA733-2 in patients with colorectal carcinoma. Cancer Immunol. Immunother. 1999. 47: 315-320.
8. Nagorsen, D., Scheibenbogen, C., Schaller, G., Leigh, B., Schmittel, A., Letsch, A., Thiel, E. et al., Differences in T-cell immunity toward tumor-associated antigens in colorectal cancer and breast cancer patients. Int. J. Cancer 2003. 105: 221-225.
9. Nagorsen, D., Keilholz, U., Rivoltini, L., Schmittel, A., Letsch, A., Asemissen, A. M., Berger, G. et al., Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer. Cancer Res. 2000. 60: 485O-4854.
10. Schwartzberg, L. S., Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma. Crit. Rev. Oncol. Hematol. 2001. 40: 17-24.
11. Ullenhag, G. J., Frodin, J. E., Mosolits, S., Kiaii, S., Hassan, M., Bonnet M. C., Moingeon, P. et al., Immunization of colorectal carcinoma patients with a recombinant canarypox virus expressing the tumor antigen Ep-CAM/KSA (ALVAC-KSA) and granulocyte macrophage colony-stimulating factor induced a tumor-specific cellular immune response. Clin. Cancer Res. 2003. 9: 2447-2456.
12. Li, W., Berencsi, K., Basak, S., Somasundaram, R., Ricciardi, R. P., Gonczol, E., Zaloudik J. et al., Human colorectal cancer (CRC) antigen C017-1A/GA733 encoded by adenovirus inhibits growth of established CRC cells in mice. J. Immunol. 1997. 159: 763-769.
13. Zaloudik, J., Li, W., Jacob, L, Kieny, M. P., Somasundaram, R., Acres, B., Song, H. et al., Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in mice. Cancer Gene Ther. 2002. 9: 382-389.
14. Basak, S., Eck S., Gutzmer, R., Smith, A. J., Birebent, B., Purev, E., Stailb, L. et al., Colorectal cancer vaccines: Antiidiotypic antibody, recombinant protein, and viral vector. Ann. N. Y. Acad. Sci. 2000. 910: 237-253.
15. Zucchelli S., Capone, S., Fattori, E., Folgori A., Di Marco, A., Casimiro, D., Simon, A. J. et al., Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J. Viral. 2000. 74: 11598-11607.
16. Shiver, J. W., Fu, T. M., Chen, L., Casimiro, D. R., Davies, M. E., Evans, R. K., Zhang, Z. Q. et al., Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 2002. 415: 331-335.
17. Mennuni, C., Calvaruso, F., Facciabene, A., Aurisicchio, L., Storto, M., Scarselli, E., Ciliberto, G. et al., Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA. Int. J. Cancer 2005. 117: 444 4SS.
18. Maecker, H. T., Dunn, H. S., Suni M. A., Khatamzas, E., Pitcher, C. J., Bunde, T., Persaud, N. et al., Use of overlapping peptide mixtures as antigens for cytokine flow cytometry. J. Immunol. Methods 2001. 255: 27-40.
19. + T-cell lymphocytosis associated with murine gamma-herpesvirus infection. Viral Immunol. 2001. 14: 391-402.
20. Casimiro, D. R., Tang, A., Perry, H. C., Long, R. S., Chen, M., Heidecker, G. J., Davies, M. E. et al., Vaccine-induced immune responses in rodents and nonhuman primates by use of a humanized human immunodeficiency virus type 1 pol gene. J. Virol. 2002. 76: 185-194.
21. McLaughlin, P. M., Harmsen, M. C., Dokter, W. H., Kroesen, B. J., van der Molen, H., Brinker, M. G., Hollema, H. et al., The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: A new model to study carcinoma-directed immunotherapy. Cancer Res. 2001. 61: 4105-4111.
22. Gallo, P., Dharmapuri, S., Nuzzo, M., Maldini, D., Iezzi, M., Cavallo, F., Musiani, P. et al., Xenogeneic immunization in mice using HER2 DNA delivered by an adenoviral vector. Int J. Cancer 2005. 113: 67-77.
23. Su, J. M., Wei, Y. Q., Tian, L., Zhao, X, Yang, L., He, Q. M., Wang, Y. et al., Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2. Cancer Res. 2003. 63: 600-607.
24. Bowne, W. B., Srinivasan, R., Wolchok, J. D., Hawkins, W. G., Blachere, N. E., Dyall, R., Lewis, J. J. et al., Coupling and uncoupling of tumor immunity and autoimmunity. J. Exp. Med. 1999. 190: 1717-1722.
25. Mendiratta, S. K., Thai, G., Eslahi, N. K., Thull, N. M., Matar M., Bronte, V. and Pericle, F., Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp1OO and TRP-2. Cancer Res. 2001. 61: 859-863.
26. Srinivasan, R. and Wolchok, J. D., Tumor antigens for cancer immunotherapy: Therapeutic potential of xenogeneic DNA vaccines. J. Transl. Med. 2004. 2: 12.
27. Wooley, P. H., Luthra, H. S., Stuart, J. M. and David, C. S., Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J. Exp. Med., 1981. 154: 688-700.
28. Mosolits, S., Markovic, K., Fagerberg, J., Frodin, J. E., Rezvany, M. R., Kiaii, S., Mellstedt, H. et al., T-cell receptor BV gene usage in colorectal carcinoma patients immunised with recombinant Ep-CAM protein or antiidiotypic antibody. Cancer Immunol. Immunother. 2005. 54: 557-570.
29. Montgomery, D. L., Shiver, J. W., Leander, K. R., Perry, H. C., Friedman, A., Martinez, D., Ulmer, J. B. et al., Heterologous and homologous protection against influenza A by DNA vaccination: Optimization of DNA vectors. DNA Cell. Biol. 1993. 12: 777-783.
30. Aurisicchio, L., Delmastro, P., Salucci V., Paz, O. G., Rovere, P., Ciliberto, G., La Monica, N. et al., Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis. J. Virol. 2000. 74: 4816-4823.
31. Cao, T. M., Lo, B., Ranheim, E. A., Grumet, F. C. and Shizuru, J. A., Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice. Proc. Natl. Acad. Sci. USA 2003. 100: 11571-11576.
32. Rizzuto, G., Cappelletti, M., Maione, D., Savino, R., Lazzaro, D., Costa, P., Mathiesen, I. et al., Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc. Natl. Acad. Sci. USA 1999. 96: 6417-6422.
33. Facciabene, A., Aurisicchio, L. and La Monica, N., Baculovirus vectors elicit antigen-specific immune responses in mice. J. Virol. 2004. 78: 8663-8672.