Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle

European Journal of Clinical Pharmacology

Volumn 62, Issue 5, 2006, Pages 347-354

  Badawi, Jasmin Katrin ^a   Li, Heng ^a   Langbein, Sigrun ^a   Kwon, Sun Tscheol ^a   Kamp, Stefan ^a   Bross, Stephan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Calcium antagonists; Diltiazem; Human detrusor muscle; Inhibitory effects; Mibefradil; Nifedipine; Nimodipine; Verapamil

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CARBACHOL; DILTIAZEM; ISOPRENALINE; MIBEFRADIL; NIFEDIPINE; NIMODIPINE; VERAPAMIL;

ADULT; AGED; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG POTENCY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION;

ADULT; AGED; ANALYSIS OF VARIANCE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; CARBACHOL; DILTIAZEM; FEMALE; HUMANS; MALE; MIBEFRADIL; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NIFEDIPINE; NIMODIPINE; POTASSIUM; URINARY BLADDER; VERAPAMIL;

EID: 33646522738     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-006-0100-8     Document Type: Article

References (34)

1. Hockerman GH, Peterson BZ, Johnson BD, Catterall WA (1997) Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol 37:361-396
2. Bernink PJLM, Prager G, Schelling A, Kobrin I (1996) Antihypertensive properties of the novel calcium antagonist mibefradil (Ro 40-5967): a new generation of calcium antagonists? Hypertension 27:426-432
3. Karam H, Clozel JP, Bruneval P, Gonzalez M-F, Ménard J (1999) Contrasting effects of selective T- and L-type calcium channel blockade on glomerular damage in DOCA hypertensive rats. Hypertension 34:673-678
4. Krayenbuhl JC, Vozeh S, Kondo-Oestreicher M, Dayer P (1999) Drug-drug interactions of new active substances: mibefradil example. Eur J Clin Pharmacol 55:559-565
5. Abernethy DR, Schwartz JB (1999) Calcium-antagonist drugs. N Engl J Med 341:1447-1457
6. Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP (1988) Multiple types of neuronal calcium channels and their selesctive modulation. Trends Neurosci 11:431-438
7. Huguenard JR (1996) Low threshold calcium currents in central nervous system neurons. Annu Rev Physiol 58:329-348
8. Perez-Reyes E (2003) Molecular physiology of low-voltage-activated T-type calcium channels. Physiol Rev 83:117-161
9. v1.2 L-type calcium channel for urinary bladder function. FASEB J 18:1159-1161
10. Hu T (2004) Costs of urinary incontinence and overactive bladder in the United States: a comparative study. Urology 63 (3):461-465
11. Andersson K-E (2000) Mode of action of alpha1-adrenoreceptor antagonists in the treatment of lower urinary tract symptoms. BJU Int 85(Suppl 2):12-18
12. Yarker YE, Goa KL, Fitton A (1995) Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging 6(3):243-262
13. Kay GG, Granville LJ (2005) Antimuscarinic agents: implications and concerns in the management of overactive bladder in the elderly. Clin Ther 27(1):127-138
14. Furukawa T, Nukada T, Miura R, Ooga K, Honda M, Watanabe S, Koganesawa S, Isshiki T (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (alpha1G) expressed in Xenopus oocytes. J Cardiovasc Pharmacol 45(3):241-246
15. De Paoli P, Cerbai E, Koidl B, Kirchengast M, Sartiani L, Mugelli A (2002) Selectivity of different calcium antagonists on T- and L-type calcium currents in guinea-pig ventricular myocytes. Pharmacol Res 46(6):491-497
16. Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA (2000) Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther 295:302-308
17. Strege PR, Bernard CE, Ou Y, Gibbons SJ, Farrugia G (2005) Effect of mibefradil on sodium and calcium currents. Am J Physiol Gastrointest Liver Physiol [Epub ahead of print]
18. Elliott RA, Norman RI, Parker SG, Whitaker RP, Castleden CM (1996) Effect of treatment with calcium antagonists in vitro and in vivo on the contractile response of isolated rat and human detrusor muscle. Clin Sci (Lond) 91(4):467-474
19. Schneider T, Fetscher C, Krege S, Michel MC (2004) Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther 309(3):1148-1153
20. Masters JG, Neal DE, Gillespie JI (1999) The contribution of intracellular Ca 2+ release to contraction in human bladder smooth muscle. Br J Pharmacol 127:996-1002
21. Kajioka S, Nakayama S, McMurray G, Abe K, Brading AF (2002) Ca(2+) channel properties in smooth muscle cells of the urinary bladder from pig and human. Eur J Pharmacol 443:19-29
22. Sui GP, Wu C, Fry CH (2003) A description of Ca2+ channels in human detrusor smooth muscle. BJU Int 92(4):476-482
23. Sui GP, Wu C, Fry CH (2001) Inward calcium currents in cultured and freshly isolated detrusor muscle cells: Evidence of a T-type calcium current. J Urol 165:621-626
24. Hashitani H, Brading AF (2003) Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140:146-158
25. Andersson K-E, Fovaeus M, Morgan E, McLorie G (1986) Comparative effects of five different calcium channel blockers on the atropine-resistant contraction in electrically stimulated rabbit urinary bladder. Neurourol Urodyn 5:579-86
26. Diederichs W, Sroka J, Graff J (1992) Comparison of Bay K 8644, nitrendipine and atropine on spontaneous and pelvic-nerve-induced bladder contractions on rat bladder in vivo. Urol Res 20(1):49-53
27. Sjogren C, Andersson KE (1979) Effects of cholinoceptor blocking drugs, adrenoceptor stimulants, and calcium antagonists on the transmurally stimulated guinea-pig urinary bladder in vitro and in vivo. Acta Pharmacol Toxicol (Copenh) 44 (3):228-234
28. Naglie G, Radomski SB, Brymer C, Mathiasen K, O'Rourke K, Tomlinson G (2002) A randomized, double-blind, placebo controlled crossover trial of nimodipine in older persons with detrusor instability and urge incontinence. J Urol 167:586-590
29. Rud T, Andersson KE, Ulmsten U (1979) Effects of nifedipine in women with unstable bladders. Urol Int 34:421-429
30. Bödeker J, Salim SA, Nagel R (1976) Wirkungen von Nifedipin bei urologischen Patienten. Dtsch med Wschr 101:1866-1868
31. Kato K, Kitada S, Chun A, Wein AJ, Levin RM (1989) In vitro intravesical instillation of anticholinergic, antispasmodic and calcium blocking agents (rabbit whole bladder model). J Urol 141(6):1471-1475
32. Hassouna M, Nishizawa O, Miyagawa I, Toguri A, Gotoh M, Elhilali M (1986) Role of calcium ion antagonists of the bladder detrusor muscle: in vitro and in vivo study. J Urol 135(6):1327-1331
33. Gotoh M, Kondo A, Mitsuya H (1987) Inhibitory effect of a calcium entry blocker (verapamil) on detrusor muscle contractility: feasibility of clinical application. Hinyokika Kiyo 33 (3):357-363
34. Mattiasson A, Ekstrom B, Andersson KE (1989) Effects of intravesical instillation of verapamil in patients with detrusor hyperactivity. J Urol 141(1):174-177