Pb2+ reduces PKCs and NF-κB in vitro

Cell Biology and Toxicology

Volumn 22, Issue 3, 2006, Pages 189-198

  Xu, S Z ^a   Shan, C J ^a   Bullock, L ^a   Baker, L ^a   Rajanna, B ^a  

^a ALCORN STATE UNIVERSITY   (United States)

Author keywords

IKK ; NF B; Pb2+; PKC

Indexed keywords

APROTININ; BESTATIN; CALPAIN; EDETIC ACID; HISTONE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; LEAD; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PHOSPHORUS 32; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; I KAPPA B KINASE;

ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; BRAIN TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME REGULATION; FETUS (ANATOMY); IMMUNOMODULATION; IMMUNOPRECIPITATION; IN VITRO STUDY; METAL BINDING; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANIMAL; BRAIN; CELL CULTURE; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALIA;

ANIMALS; BRAIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; I-KAPPA B KINASE; LEAD; NF-KAPPA B; PROTEIN KINASE C; RATS;

EID: 33646509220     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-006-0024-1     Document Type: Article

References (40)

1. Albensi BC, Mattson MP. Evidence for the involvement of TNF and NF-εB in hippocampal synaptic plasticity. Synapse. 2000;35:151-9.
2. Burke MA, Bothwell M. p75 neurotrophin receptor mediates neurotrophin activation of NF-kappa B and induction of iNOS expression in P19 neurons. J Neurobiol. 2003;55:191-203.
3. Chen LF, Greene WC. Shaping the nuclear action of NF-κB. Nat Rev-Mol Cell Biol. 2004;5:392-401.
4. Chen L, Hahn H, Wu G, et al. Opposing cardio-protective actions and parallel hypertrophic effects of δPKC and εPKC. Proc Natl Acad Sci USA. 2001;98:11114-9.
5. Colombo PJ, Wetsel WC, Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc Natl Acad Sci USA. 1997;94:14195-9.
6. Coppi AA, Lesniak J, Zieba D, Schanne FA. The effect of lead on PKC isoforms. Ann NY Acad Sci. 2000;919:304-6.
7. 2+ effects on brain protein kinase C activity. Environ Res. 2002;90:191-9.
8. Culmsee C, Siewe J, Junker V, et al. Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. J Neuron Sci. 2003;23:8586-95.
9. Gavazzo P, Gazzoli A, Mazzolini M, Marchetti C. Lead inhibition of NMDA channels in native and recombinant receptors. NeuroReport. 2001;12:3121-5.
10. Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP. Regulation of protein kinase C-β1 by two protein-tyrosine kinase, btk ans syk. Proc Natl Acd Sci USA. 2000;97:7423-8.
11. Lasley SM, Gilbert ME. Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level. Toxicol Sci. 2002;66:139-47.
12. Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol Cell Biol. 1990;10:2327-34.
13. Lin WW, Wang CW, Chuang DM. Effects of depolarization and NMDA antagonists on the survival cerebella granule cells: a pivotal role for protein kinase C isoforms. J Neurochem. 1997;68:2577-86.
14. Liu H, Mcphaerson BC, Yao Z. Reconditioning attenuates apoptosis and necrosis: role of protein kinase C-ε and -δ isoforms. Am J Physiol Heart Circ Physiol. 2001;281:H404-10.
15. Long GJ, Rosen JF, Schanne FA. Lead activation of protein kinase C from rat brain. J Biol Chem. 1994;269:834-7.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265.
17. Madrigal JLM, Moro MA, Lizasoain I, et al. Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor κB-mediated mechanism. 2001;76:532-8.
18. Markovac J, Goldstein GW. Picomolar concentrations of lead stimulate brain protein kinase C. Nature. 1988;334:71-3.
19. Mattson MP, Culmsee C, Yu Z, Camadola S. Roles of nuclear factor κB in neuronal survival and plasticity. J Neurochem. 2000;74:443-56.
20. Meffert M, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D. NF-κB functions in synaptic signalling and behaviour. Nat Neurosci. 2003;6:1072-8.
21. Mischak H, Goodnight JA, Kolch W, et al. Overexpression of protein kinase C-delta and epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence and tumorigenicity. J Biol Chem. 1993;268:6090-6.
22. Murriel CL, Mochly-Rosen D. Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Arch Biochem Biophys. 2003;420:246-54.
23. Murakami K, Feng G, Chen SG. Inhibition of brain protein kinase C subtypes by lead. J Pharmcol Exp Ther. 1992;264:757-61.
24. Needleman HL. The future challenge of lead toxicity. Environ Health Perspect. 1990;89:85-9.
25. 2+ exposure affects hippocampal protein kinase Cγ gene and protein expression in rats. Neurosci Lett. 2001;298:212-6.
26. 2+ during development. Mol Brain Res. 1999;66:42-9.
27. Olivi L, Sisk J, Bressler J. The involvement of lipid activators of protein kinase C in the induction of ZIF268 in PC12 cells exposed to lead. Neurochem Res. 2003;28:65-71.
28. Qu XW, Wang H, Deplanen IG, Kozenfeld RA, Hsueh W. Neuronal nitric oxide synthase (NOS) regulates the expression of inducible NOS in rat small intestine via modulation of nuclear factor kappa B. FASEB J. 2001;15:439-46.
29. Rajanna B, Chetty CS, Rajanna S, Hall E, Fail S, Yallapragada PR. Modulation of protein kinase C by heavy metals. Toxicol Lett. 1995;81:197-203.
30. Ramesh GT, Jadhav AL. Levels of protein kinase C and nitric oxide synthase activity in rats exposed to sub chronic low level lead. Mol Cell Biochem. 2001;223:27-33.
31. Ramesh GT, Manna SK, Aggarwal BB, Jadhav A. Lead activates nuclear transcription factor-κB, activator protein-1 and amino-terminal c-Jun kinase in pheochromocytoma cells. Toxicol Appl Pharmacol. 1999;155:280-6.
32. Ramesh GT, Manna SK, Aggarwal BB, Jadhav A. Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspase in the rat brain. Toxicol Lett. 2001;123:195-207.
33. Shukla R, Bornschein RL, Dietrich KN, et al. Fetal and infant lead exposure: effects on growth in stature. Pediatrics. 1989;84:604-612.
34. Sizemore N, Leung S, Stark GR. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol Cell Biol. 1999;19:4798-805.
35. Stahelin RV, Digman MA, Medkova M, et al. Diacylglycerol-induced membrane targeting and activation of protein kinase CE. J Biol Chem. 2005;280:19784-93.
36. Sun X, Tian X, Tomsig JL, Suszkiw JB. Analysis of differential effects of Pb on protein kinase C isozymes. Toxicol Appl Pharmacol. 1999;156:40-5.
37. Tremblay R, Hewitt K, Lesiuk H, Mealing G, Morley P, Durkin JP. Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons. J Neuronchem. 1999;72:102-11.
38. Wei W. Neurotoxicology of the brain barrier system: new implications. J. Toxicol Clin Toxicol. 2001;39:711-9.
39. 2+-induced reductions of NMDA receptor subunits in vitro. NeuroToxicology. 2005a [In press, available online].
40. Xu SZ, Bullock L, Shan CJ, Cornelius K, Rajanna B. PKC isoforms were reduced by Pb in developing rat brain. Int J Dev Neurosci. 2005b;23:53-64.