Levels of protein kinase C and nitric oxide synthase activity in rats exposed to sub chronic low level lead

Molecular and Cellular Biochemistry

Volumn 223, Issue 1-2, 2001, Pages 27-33

  Ramesh, G T ^a   Jadhav, A L ^a  

^a TEXAS SOUTHERN UNIVERSITY   (United States)

Author keywords

Lead; NOS; PKC; Rat brain

Indexed keywords

ACETIC ACID; LEAD ACETATE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXPOSURE; LEAD BLOOD LEVEL; MALE; MODULATION; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CHILD; HUMANS; LEAD; MALE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; RATS; RATS, LONG-EVANS; SIGNAL TRANSDUCTION;

EID: 0034785053     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017549003114     Document Type: Article

References (47)

1. Toxicological Profile for Lead
2. Preventing lead poisoning in young children
3. Neuropsychologic function in children exposed to environmental Pb
4. Postnatal lead exposure and MK-801 sensitivity
5. Biologically based, quantitative risk assessment of neurotoxicants
6. Region-specific alteration in dopamine and serotonin metabolism in brains of rats exposed to low levels of lead
7. Alterations in acquisition and pattern of responding in rats sub chronically exposed to low levels of lead
8. Pb-induced alteration in tyrosine hydroxylase activity in rat brain
9. Region-specific alterations in tyrosine hydroxylase activity in rats exposed to lead
10. Cellular interactions between lead and calcium
11. 2+ homeostasis in cultured osteoclastic bone cells
12. 2+ in calmodulin
13. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids
14. Endogenous nitric oxide synthesis: Biological functions and pathophysiology
15. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme
16. Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin
17. The versatile and complex enzymology of nitric oxide synthase
18. The neuronal expression of nitric oxide synthase altered synaptic terminals after early lead exposure
19. A tale of two contingent protein kinase C activators: Both neutral and acidic lipids regulate synaptic plasticity and information storage
20. Studies and prospectives of protein kinase C
21. Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid dependent protein kinase
22. Mechanism of activation of protein kinase C: Roles of diolein and phosphatidylserine
23. Picomolar concentrations of lead stimulate brain protein kinase C
24. Inhibition of brain protein kinase C subtypes by lead
25. Modulation of protein kinase C by heavy metals
26. Effects of early lead exposure on neurotransmitter systems in the brain. A review with commentary
27. Mechanisms of lead neurotoxicity, or looking beyond the lamppost
28. Performance and exposure indices of rats to low concentrations of lead
29. The determination of lead and cadmium in blood and manganese and aluminium in serum
30. 3H] dopa in various regions of the brain
31. A rapid and sensitive method for the quantification of microgram quantities of protein
32. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
33. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets; procedure and applications
34. Trimethyltin stimulates protein kinase C translocation through receptor-mediated phospholipase C activation in PC12 cells
35. Low level subchronic exposure to lead does not affect nitric oxide synthase activity in rat frontal cortex
36. Contribution of protein kinase C and glutamate in Pb-induced cytotoxicity
37. Casarett and Doull's Toxicology: The Basic Science of Poisons
38. Developmental lead exposure and two way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus
39. Protein kinase C in rat brain is altered by developmental lead exposure
40. Mechanisms of lead neurotoxicity
41. The role of protein kinase C in induction of nitric oxide synthesis by murine macrophages
42. Protein kinase C modulates receptor independent activation of endothelial nitric oxide synthase
43. Lead-induced hypertension: Interplay of nitric oxide and reactive oxygen species
44. Nitric oxide synthase regulatory sites: Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites
45. 2+ stimulated nitric oxide synthase activity from rat cerebellum
46. Oxidative mechanisms in the toxicity of metal ions
47. Lead inhibits nitric oxide in vitro by murine splenic macrophages