Differential HHV-6A gene expression in T Cells and primary human astrocytes based on multi-virus array analysis

GLIA

Volumn 53, Issue 8, 2006, Pages 789-798

  Yao, Karen ^a,e   Mandel, Matthew ^a,d   Akyani, Nahid ^a   Maynard, Kristen ^a   Sengamalay, Naomi ^b   Fotheringham, Julie ^a   Ghedin, Elodie ^b   Kashanchi, Fatah ^c   Jacobson, Steven ^a,f  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b J CRAIG VENTER INSTITUTE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f Building 10 ^*  (United States)

Author keywords

Astrocytes; HHV 6; Multi virus array; Multiple sclerosis; Viral persistency

Indexed keywords

VIRUS DNA;

ARTICLE; ASTROCYTE; BRAIN BIOPSY; CD4 LYMPHOCYTE COUNT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA DETERMINATION; EPSTEIN BARR VIRUS; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLIA CELL; HEPATITIS B VIRUS; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 2; IMMUNE RESPONSE; IN VITRO STUDY; INFECTION; MULTIPLE SCLEROSIS; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS DETECTION; VIRUS GENE; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN;

ASTROCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; CHILD; DNA, VIRAL; ENCEPHALITIS, VIRAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 6, HUMAN; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ROSEOLOVIRUS INFECTIONS; TRANS-ACTIVATION (GENETICS); VIRAL LOAD; VIRUS REPLICATION;

EID: 33646509004     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20333     Document Type: Article

References (36)

1. Ahlqvist J, Fotheringham J, Akhyani N, Yao K, Fogdell-Hahn A, Jacobson S. 2005. Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes. J Neurovirol 11:384-394.
2. Akhyani N, Berti R, Brennan MB, Soldan SS, Eaton JM, McFarland HF, Jacobson S. 2000. Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J Infect Dis 182:1321-1325.
3. Alba MM, Lee D, Pearl FM, Shepherd AJ, Martin N, Orengo CA, Kellam P. 2001. VIDA: a virus database system for the organization of animal virus genome open reading frames. Nucleic Acids Res 29:133-136.
4. Berti R, Soldan SS, Akhyani N, McFarland HF, Jacobson S. 2000. Extended observations on the association of HHV-6 and multiple sclerosis. J Neurovirol 6:S85-S87.
5. Cermelli C, Berti R, Soldan SS, Mayne M, D'Ambrosia JM, Ludwin SK, Jacobson S. 2003. High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection. J Infect Dis 187:1377-1387.
6. Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M, et al. 1995. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA 92:7440-7444.
7. Chambers J, Angulo A, Amaratunga D, Guo H, Jiang Y, Wan JS, Bittner A, Frueh K, Jackson MR, Peterson PA, et al. 1999. DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J Virol 73:5757-5766.
8. Cuende JI, Ruiz J, Civeira MP, Prieto J. 1994. High prevalence of HHV-6 DNA in peripheral blood mononuclear cells of healthy individuals detected by nested-PCR. J Med Virol 43:115-118.
9. De Bolle L, Van Loon J, De Clercq E, Naesens L. 2005. Quantitative analysis of human herpesvirus 6 cell tropism. J Med Virol 75:76-85.
10. Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyer A, Heiss JD, Cogen P, Gaillard WD, Sato S, et al. 2003. Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections. Neurology 61:1405-1411.
11. Donati D, Martinelli E, Cassiani-Ingoni R, Ahlqvist J, Hou J, Major EO, Jacobson S. 2005. Variant-specific tropism of human herpesvirus 6 in human astrocytes. J Virol 79:9439-9448.
12. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
13. Flebbe-Rehwaldt LM, Wood C, Chandran B. 2000. Characterization of transcripts expressed from human herpesvirus 6A strain GS immediate-early region B U16-U17 open reading frames. J Virol 74:11040-11054.
14. Fogdell-Hahn A, Soldan SS, Jacobson S. 2002. Association of chronic progressive neurological disease and ubiquitous viral agents: lessons from human herpesvirus 6 and multiple sclerosis. Mol Psychiatry 7:S29-S31.
15. French C, Menegazzi P, Nicholson L, Macaulay H, DiLuca D, Gompels UA. 1999. Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6. Virology 262:139-151.
16. Ghedin E, Pumfery A, de la Fuente C, Yao K, Miller N, Lacoste V, Quackenbush J, Jacobson S, Kashanchi F. 2004. Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis. Retrovirology 1:10.
17. Goodman AD, Mock DJ, Powers JM, Baker JV, Blumberg BM. 2003. Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions. J Infect Dis 187:1365-1376.
18. He J, McCarthy M, Zhou Y, Chandran B, Wood C. 1996. Infection of primary human fetal astrocytes by human herpesvirus 6. J Virol 70:1296-1300.
19. Jacobson S. 1998. Association of human herpesvirus-6 and multiple sclerosis: here we go again? J Neurovirol 4:471-473.
20. Kondo K, Nozaki H, Shimada K, Yamanishi K. 2003. Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency. J Virol 77:10719-10724.
21. Mirandola P, Menegazzi P, Merighi S, Ravaioli T, Cassai E, Di Luca D. 1998. Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 72:3837-3844.
22. Nitsche A, Muller CW, Radonic A, Landt O, Ellerbrok H, Pauli G, Siegert W. 2001. Human herpesvirus 6A DNA Is detected frequently in plasma but rarely in peripheral blood leukocytes of patients after bone marrow transplantation. J Infect Dis 183:130-133.
23. Ohyashiki JH, Takaku T, Ojima T, Abe K, Yamamoto K, Zhang Y, Ohyashiki K. 2005. Transcriptional profiling of human herpesvirus type B (HHV-6B) in an adult T cell leukemia cell line as in vitro model for persistent infection. Biochem Biophys Res Commun 329:11-17.
24. Opsahl ML, Kennedy PG. 2005. Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain 128:516-527.
25. Oster B, Hollsberg P. 2002. Viral gene expression patterns in human herpesvirus 6B-infected T cells. J Virol 76:7578-7586.
26. Paulose-Murphy M, Ha NK, Xiang C, Chen Y, Gillim L, Yarchoan R, Meltzer P, Bittner M, Trent J, Zeichner S. 2001. Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus). J Virol 75:4843-4853.
27. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, et al. 1997. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 3:1394-1397.
28. Soldan SS, Fogdell-Hahn A, Brennan MB, Mittleman BB, Ballerini C, Massacesi L, Seya T, McFarland HF, Jacobson S. 2001. Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis. Ann Neurol 50:486-493.
29. Soldan SS, Leist TP, Juhng KN, McFarland HF, Jacobson S. 2000. Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients. Ann Neurol 47:306-313.
30. Takemoto M, Shimamoto T, Isegawa Y, Yamanishi K. 2001. The R3 region, one of three major repetitive regions of human herpesvirus 6, is a strong enhancer of immediate-early gene U95. J Virol 75:10149-10160.
31. Taniguchi T, Shimamoto T, Isegawa Y, Kondo K, Yamanishi K. 2000. Structure of transcripts and proteins encoded by U79-80 of human herpesvirus 6 and its subcellular localization in infected cells. Virology 271:307-320.
32. Villoslada P, Juste C, Tintore M, Llorenc V, Codina G, Pozo-Rosich P, Montalban X. 2003. The immune response against herpesvirus is more prominent in the early stages of MS. Neurology 60:1944-1948.
33. Wang D, Coscoy L, Zylberberg M, Avila PC, Boushey HA, Ganem D, DeRisi JL. 2002. Microarray-based detection and genotyping of viral pathogens. Proc Natl Acad Sci USA 99:15687-15692.
34. Yamashita N, Morishima T. 2005. HHV-6 and seizures. Herpes 12:46-49.
35. Yoshikawa T, Asano Y, Akimoto S, Ozaki T, Iwasaki T, Kurata T, Goshima F, Nishiyama Y. 2002. Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis. J Med Virol 66:497-505.
36. Zou P, Isegawa Y, Nakano K, Haque M, Horiguchi Y, Yamanishi K. 1999. Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J Virol 73:5926-5933.