Cathelicidin deficiency predisposes to eczema herpeticum

Journal of Allergy and Clinical Immunology

Volumn 117, Issue 4, 2006, Pages 836-841

  Howell, Michael D ^a   Wollenberg, Andreas ^b   Gallo, Richard L ^c   Flaig, Michael ^b   Streib, Joanne E ^a   Wong, Cathy ^c   Pavicic, Tatjana ^b   Boguniewicz, Mark ^a   Leung, Donald Y M ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimicrobial peptides; atopic dermatitis; eczema herpeticum; herpes simplex virus

Indexed keywords

BIOLOGICAL MARKER; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN D; IMMUNOGLOBULIN E; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; ASSAY; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 2; HOST RESISTANCE; HOST SUSCEPTIBILITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION SENSITIVITY; INNATE IMMUNITY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN INFECTION; STATISTICAL SIGNIFICANCE; VIRUS REPLICATION;

ADULT; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BASE SEQUENCE; DERMATITIS, ATOPIC; DNA, VIRAL; HERPESVIRUS 2, HUMAN; HUMANS; IMMUNITY, NATURAL; IMMUNOGLOBULIN E; KAPOSI VARICELLIFORM ERUPTION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECOMBINANT PROTEINS; VIRUS REPLICATION;

EID: 33646482761     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.12.1345     Document Type: Article

References (18)

1. Leung D.Y., and Bieber T. Atopic dermatitis. Lancet 361 (2003) 151-160
2. Leung D.Y., Boguniewicz M., Howell M.D., Nomura I., and Hamid Q.A. New insights into atopic dermatitis. J Clin Invest 113 (2004) 651-657
3. Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T., et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347 (2002) 1151-1160
4. Nomura I., Goleva E., Howell M.D., Hamid Q.A., Ong P.Y., Hall C.F., et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171 (2003) 3262-3269
5. Wollenberg A., Wetzel S., Burgdorf W.H.C., and Haas J. Viral infections in atopic dermatitis: pathogenic aspects and clinical management. J Allergy Clin Immunol 112 (2003) 667-674
6. Wollenberg A., Zoch C., Wetzel S., Plewig G., and Przybilla B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol 49 (2003) 198-205
7. Sanderson I.R., Brueton L.A., Savage M.O., and Harper J.I. Eczema herpeticum: a potentially fatal disease. Br Med J (Clin Res Ed) 294 (1987) 693-694
8. Weidmann M., Meyer-Konig U., and Hufert F.T. Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR. J Clin Microbiol 41 (2003) 1565-1568
9. Tukey J. Exploratory data analysis (1977), Addison Wesley, Reading (NY)
10. Howell M.D., Novak N., Bieber T., Pastore S., Girolomoni G., Boguniewicz M., et al. Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. J Invest Dermatol 125 (2005) 738-745
11. Bacharier L.B., and Geha R.S. Molecular mechanisms of IgE regulation. J Allergy Clin Immunol 105 suppl (2000) S547-S558
12. Howell M.D., Jones J.F., Kisich K.O., Streib J.E., Gallo R.L., and Leung D.Y. Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J Immunol 172 (2004) 1763-1767
13. Erdag G., and Morgan J.R. Interleukin-1alpha and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts. Ann Surg 235 (2002) 113-124
14. Frohm M., Agerberth B., Ahangari G., Stahle-Backdahl M., Liden S., Wigzell H., et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272 (1997) 15258-15263
15. Yasin B., Pang M., Turner J.S., Cho Y., Dinh N.N., Waring A.J., et al. Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. Eur J Clin Microbiol Infect Dis 19 (2000) 187-194
16. Gordon Y.J., Huang L.C., Romanowski E.G., Yates K.A., Proske R.J., and McDermott A.M. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res 30 (2005) 385-394
17. Hamid Q., Boguniewicz M., and Leung D.Y. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94 (1994) 870-876
18. Lagace-Simard J., Portnoy J.D., and Wainberg M.A. High levels of IgE in patients suffering from frequent recurrent herpes simplex lesions. J Allergy Clin Immunol 77 (1986) 582-585